Could a diabetes drug curb alcohol cravings in schizophrenia?

NCT ID NCT06939088

Recruiting now Disease control Sponsor: Anders Fink-Jensen, MD, DMSci Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking days and brain activity. The goal is to see if this drug reduces alcohol intake and cravings in a group that badly needs better treatment options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide (Mounjaro)
What this could lead to: If it works, this could point toward a new treatment option for alcohol use disorder in people with schizophrenia, a group with few effective therapies.
What could go wrong: This is an early Phase 2 trial with only 108 participants. The results may not apply to everyone, and tirzepatide's effects on alcohol craving are still unproven.

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Conditions

The condition(s) this trial relates to.

alcohol abuse alcohol dependence psychotic disorder schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL ABUSE/DEPENDENCE ALCOHOL DEPENDENCE ALCOHOL USE DISORDER ALCOHOLISM SCHIZOPHRENIA SCHIZOPHRENIA AND DISORDERS WITH PSYCHOTIC FEATURES SCHIZOPHRENIA AND SCHIZOPHRENIA SPECTRUM PSYCHOSIS SCHIZOPHRENIA DISORDERS

Contacts and locations

Locations

Department of Psychiatry, Aalborg University Hospital
RECRUITING

Aalborg, Denmark, 9000, Denmark
Psychiatric Center Copenhagen, Frederiksberg Hospital
RECRUITING

Frederiksberg, Denmark, 2100, Denmark

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