ALCOHOLISM

This study is testing whether a weekly injection called tirzepatide, currently used for diabetes and weight loss, can help reduce heavy alcohol use in people who also have schizophrenia. About 108 participants will receive either the real drug or a placebo (dummy injection) for 2…

This study is testing whether a monthly injection of a medication called naltrexone helps people who drink primarily for pleasure reduce their heavy drinking more than a placebo (inactive) shot. 60 adults with alcohol use disorder will receive either the real medication or a plac…

This study is testing whether a non-invasive brain stimulation treatment can help people with moderate to severe alcohol use disorder reduce their heavy drinking. 186 participants will receive either the real magnetic stimulation treatment or a sham (fake) treatment over 6 months…

This study is testing if adding cannabidiol (CBD) to an existing medication (naltrexone) can better reduce alcohol cravings in people with alcohol dependence. It will involve 150 adults who are already in a treatment program. Participants will take either a high or low dose of CB…

This study is testing whether a single dose of ketamine, combined with a special brain training session using an MRI scanner, can help people with alcohol use disorder drink less. Researchers will compare the effects of real ketamine and real brain training against placebo and sh…

This study is testing if offering alcohol use disorder treatment directly in a liver disease clinic helps patients newly diagnosed with alcohol-related liver disease stay sober. About 221 patients will be randomly assigned to either receive this direct offer of treatment plus sta…

This study aims to understand why people relapse after starting treatment for alcohol or drug use. Researchers will collect data from 10,000 adults using a smartphone app that tracks daily activities, mood, and substance use for up to six months. The goal is to build a large data…

This study aims to develop and test simple computer tasks that can be used during brain scans to better understand how alcohol use disorders affect behavior, thinking, and decision-making. Researchers are recruiting 400 adults, including both healthy volunteers and people with al…

This is a long-term observational study aiming to understand why medical students experience high rates of depression and anxiety. Researchers will follow up to 10,000 students over many years, comparing those in medical school to those who were not accepted. The goal is to ident…

This study aims to understand how alcohol use disorder changes the brain. Researchers will use MRI brain scans and computer games to compare brain structure and function in adults with and without alcohol dependence. The goal is to link these brain differences to behavior, person…

This study aims to understand why people with bipolar disorder are at such high risk for suicide. Researchers will look at how factors like childhood trauma, drug use, and aggressive impulses might lead to suicidal thoughts and actions. They are also testing a 6-week group therap…