ALCOHOLISM

This study tests whether combining ketamine with real-time brain training (neurofeedback) can help people with alcohol use disorder reduce their drinking. About 75 adults who want to cut back or stop drinking will receive either ketamine or a placebo, along with real or fake neur…

This study tests a non-invasive brain stimulation device called Deep TMS to see if it can reduce heavy drinking in people with moderate to severe alcohol use disorder. About 186 adults aged 18-86 will receive either real or fake (sham) stimulation over several weeks. The goal is …

This study tests whether offering specialized alcohol treatment to people newly diagnosed with alcohol-related liver disease helps them stop drinking. About 221 adults with early liver damage from heavy drinking will be randomly assigned to either get this treatment or standard c…

This study tests whether tirzepatide, a drug approved for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. About 108 participants will receive either tirzepatide or a placebo for 16 weeks, and researchers will track changes in hea…

This study is testing if a monthly injection of naltrexone helps people who drink primarily for pleasure (reward drinkers) reduce heavy drinking more than a placebo shot. About 60 adults with alcohol use disorder will receive either the active medication or a placebo injection fo…

This study tests whether adding cannabidiol (CBD) to the standard medication naltrexone helps reduce alcohol cravings more than naltrexone alone. About 150 adults with alcohol addiction who experience strong cravings will take either a high or low dose of CBD plus naltrexone, or …

This study aims to build a large data repository by collecting information from 10,000 adults who have used alcohol or drugs in the past 30 days. Participants will use a smartphone app that tracks things like screen time, app usage, and movement, and complete daily and monthly su…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these risks and improve quality of life. About 130 English-speaking adults with bipolar d…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop reliable tools for future studies, not…

This study aims to understand why medical students develop depression and other mental health problems. Researchers will follow up to 10,000 students for up to 12 years each, comparing those who enter medical school with those who do not. Participants fill out yearly online quest…