Ketamine's secret: family history of alcoholism may boost antidepressant effects
NCT ID NCT02122562
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study explores why ketamine, a fast-acting antidepressant, works better in people with a family history of alcohol use disorder. Researchers will give a single low-dose ketamine infusion to 60 adults with treatment-resistant depression while scanning their brains with powerful 7T MRI. They aim to measure changes in brain chemistry and connectivity to understand the biological reasons behind the enhanced response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketamine
What this could lead to
If successful, this could help doctors personalize depression treatment by identifying who will benefit most from ketamine.
What could go wrong
This is a small, early-phase study (60 people) focused on understanding mechanisms, not proving effectiveness. Results may not apply to all depression patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••