MAJOR DEPRESSION

This study aims to see if a new medical device, which combines a blood test with a short questionnaire, can accurately identify bipolar disorder in people who are currently experiencing a major depressive episode. About 623 adults in primary care will provide a blood sample and a…

This study is testing whether a stronger version of a non-invasive brain stimulation technique, called tDCS, is safe for people with major depression. About 20 adults will receive mild electrical pulses through electrodes on their scalp over 5 days. Researchers will monitor side …

This study tests whether a personalized, algorithm-based psychotherapy is more effective than usual one-on-one therapy for adults with major depression complicated by personality problems or past trauma. About 150 people in Chile's public mental health system will be randomly ass…

This study looks at whether breathing and aerobic exercises can affect certain brain and inflammation markers in people with major depression. Researchers will measure substances linked to nerve health and inflammation in 40 adults aged 18 to 40. The goal is to understand how exe…

This study looks at how depression in older adults (late-life depression) affects memory, thinking speed, and language over time. Researchers will follow 120 participants for 30 months, using brain scans and blood tests to track changes. The goal is to understand why some people …

This study looks at why a single low dose of ketamine helps some people with hard-to-treat depression more than others. Researchers will use brain scans to measure brain chemical changes in 60 adults with depression, comparing those with and without a family history of alcohol us…

This study aims to understand how continuous theta-burst stimulation (cTBS), a form of transcranial magnetic stimulation, changes brain activity in people with depression. Researchers will test whether cTBS works by weakening overactive brain connections or by boosting the brain'…

This study aims to find genetic markers that can predict which children and youth (ages 6-24) with depression, anxiety, or OCD may experience behavioral activation—a side effect like agitation or restlessness—when taking SSRI antidepressants. Researchers will analyze DNA from 160…

This study looks at how sleep inertia—the grogginess you feel right after waking up—affects attention in people with major depression. Researchers will compare three groups: depressed patients with sleep inertia, depressed patients without it, and healthy controls. They will use …

This study looks at how ketamine, a fast-acting antidepressant, works in the brain. Researchers want to see if blocking a specific receptor (AMPA) changes ketamine's effects. About 70 adults with treatment-resistant depression will stay at the clinic for 5 weeks, receive ketamine…

This study watches how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or migraines, as well as healthy volunteers. Over two years, participants wear activity trackers and light sensors, answer daily mood questions on…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study follows 1,000 adults with hard-to-treat depression or OCD who are getting advanced treatments like ECT, TMS, or ketamine. Researchers collect brain scans, voice recordings, and other tests before, during, and after treatment. The goal is to find biological markers that…