Scientists probe Brain's inner wiring to unlock depression treatment secrets

This study aims to understand how a specific type of brain stimulation, called continuous theta-burst stimulation (cTBS), affects brain activity in people with depression. Researchers will give participants a single dose of one of four FDA-approved drugs (or a placebo) that either boost or block key brain chemicals, then measure brain responses with EEG. The goal is to figure out whether cTBS works by weakening overactive connections or by strengthening the brain's natural braking system. This knowledge could lead to more personalized and effective treatments for depression.