Scientists probe Brain's inner wiring to unlock depression treatment secrets

NCT ID NCT07560878

Recruiting now Knowledge-focused Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand how a specific type of brain stimulation, called continuous theta-burst stimulation (cTBS), affects brain activity in people with depression. Researchers will give participants a single dose of one of four FDA-approved drugs (or a placebo) that either boost or block key brain chemicals, then measure brain responses with EEG. The goal is to figure out whether cTBS works by weakening overactive connections or by strengthening the brain's natural braking system. This knowledge could lead to more personalized and effective treatments for depression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••