Can a common supplement lift depression and sharpen memory in seniors?

NCT ID NCT05257902

Completed Symptom relief Sponsor: Samsung Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The study aims to see if adding choline alphoscerate leads to better outcomes than antidepressants alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a dietary supplement called choline alphoscerate
What this could lead to: If it works, this could point toward a safe add-on treatment for depression and memory issues in older adults.
What could go wrong: This is a mid-sized trial, and the supplement may prove no better than placebo. Potential side effects are not yet well understood in this population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MAJOR DEPRESSION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION

Contacts and locations

Locations

Samsung Medical Center

Seoul, Irwon-dong, Gangnam-gu, 135710, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.