Samsung Medical Center

This study tests whether a drug-coated balloon is better than a drug-eluting stent for treating complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach reduces the…

This study tests a combination of two targeted drugs, lazertinib and tepotinib, in people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer) that has stopped responding to lazertinib alone due to a change in the MET gene. About 47 participants w…

This study compares an artificial intelligence (AI) method to the standard invasive method for guiding stenting in people with narrowed heart arteries. About 2100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see if the…

This study tests whether adding a special type of radiation, called Adaptive Pulse Radiotherapy, to standard immunotherapy can help people with advanced solid tumors. About 35 participants will receive their usual immunotherapy plus 2-3 high-dose radiation sessions. Researchers w…

This study tests whether giving the immunotherapy drug avelumab after standard chemotherapy can help prevent upper tract urothelial cancer from coming back. About 48 adults who have already had surgery and at least 3 cycles of chemo will receive avelumab as a maintenance treatmen…

This study looks at whether people with heart disease and a high risk of bleeding can safely stop taking antiplatelet drugs (blood thinners) after a drug-coated balloon angioplasty. Participants must have been stable for at least a year after the procedure. The goal is to see if …

This study tests a shorter course of radiation therapy combined with chemotherapy for cervical cancer. Normally, treatment takes 7-8 weeks, but this approach aims to finish in less time while still being effective. The trial includes 34 adults with advanced cervical cancer and wi…

This study compares two procedures for removing small precancerous growths (≤1 cm) in the stomach: argon plasma coagulation (APC), a simpler, less invasive method, and endoscopic mucosal resection (EMR), which removes tissue for testing. About 160 adults with low-grade dysplasia …

This study tests a drug called patritumab deruxtecan in adults with advanced solid tumors that have a rare genetic change called an NRG1 fusion. The goal is to see if the drug can shrink tumors or stop them from growing. About 30 people will take part, and the study is currently …

This study looks at whether starting treatment early for hidden atrial fibrillation (a type of irregular heartbeat) can reduce the amount of time the heart is in this rhythm. About 520 adults with heart devices that detect these hidden episodes will be split into two groups: one …

This study tests a new drug combination for people with a type of blood cancer (B-cell lymphoma) that has come back or not responded to treatment and has spread to the brain or spinal cord. The experimental drug selinexor is added to a standard chemotherapy regimen to see if it w…

This study looks at whether people who had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either stop or continue the medication. The goal is to see if stopping is just as …

This study tests a new way of giving radiation called PULSAR, which delivers short, powerful proton beam pulses spaced weeks apart. The goal is to better control pancreatic tumors while reducing side effects. About 47 adults with locally advanced or limited spread pancreatic canc…

This study is for men whose prostate cancer has returned after surgery, shown by rising PSA levels. It compares a standard few weeks of radiation to a much shorter course (just a few days) to see if the shorter option works just as well with fewer side effects. The goal is to mak…

This study tests whether the drug osimertinib can stop or shrink small, hazy spots (called ground-glass nodules) in the lungs of people who have already had surgery for a type of lung cancer with a specific gene change (EGFR mutation). About 59 adults aged 30–75 will take one pil…

This study tests whether adjusting a pacemaker to a personalized, optimal heart rate can improve symptoms and quality of life in people with heart failure and a slow heartbeat. About 106 participants will be randomly assigned to either the new optimized pacing strategy or standar…

This study tests if a smart board device can help people with brain disorders (like stroke or brain injury) improve arm function from home. Forty adults with arm weakness for at least 3 months will either use the smart board or do standard home therapy. The goal is to see which a…

This study tests whether personalized brain stimulation (rTMS) can improve arm and hand function better than standard treatment in people who had a stroke within the past 3 months. About 120 participants will receive either a customized or conventional stimulation protocol. The g…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove or do standard home exercises. The goal is to see if the glove…

This study tests a personalized form of brain stimulation (rTMS) to improve walking in people with Parkinson's disease. Researchers will tailor the stimulation target based on each patient's brain function, rather than using a one-size-fits-all approach. The trial involves 60 par…

This study is collecting data from 2,200 children (ages 0-12) who visit the emergency room with breathing problems. Researchers will use videos and medical information to train an artificial intelligence system to automatically recognize different breathing patterns. The goal is …

This study looks at whether chest CT scans can help predict how well lung cancer responds to chemoimmunotherapy given before surgery. Researchers will compare scan images with actual tumor response after surgery in 150 adults with resectable non-small cell lung cancer. The goal i…

This study aims to see if a special type of PET-CT scan (F-18 FDG PET-CT) is better than standard imaging (like CT scans) at tracking how well treatment is working in people with advanced breast cancer. About 100 adults starting their first systemic therapy will be followed for 4…

This study is collecting medical information and tissue samples from 350 head and neck cancer patients at Samsung Medical Center. Researchers want to understand why some patients respond better to treatment than others. The goal is to find biological markers that can help guide p…

This study aims to find genetic markers in tissue and blood that can help diagnose early stomach cancer and precancerous growths, and predict if the cancer will come back after treatment. Researchers will analyze samples from 1,730 adults with these conditions. The goal is to imp…

This study is for adults with a rare condition called hemophagocytic lymphohistiocytosis (HLH), where the immune system becomes overactive and damages the body. Researchers will track 81 participants to better understand the disease and see how well treatments like steroids and c…

This study looks at whether a special heart scan (coronary CT angiography) is better than standard follow-up care for high-risk patients who have had a stent placed to open blocked arteries. About 3,500 adults aged 19 and older with complex heart conditions will be enrolled. The …

This study is creating a huge, organized database of up to 800,000 Korean patients with heart or brain blood vessel diseases. Researchers will collect medical history and follow patients for years to track their health outcomes. The goal is to understand how these diseases progre…

This study is for people with advanced head and neck cancer who are receiving standard immunotherapy and chemotherapy. Researchers want to understand why only about 15% of patients respond well to these treatments. By analyzing tumor and blood samples before and after treatment, …

This study aims to create and test a new way to set therapy goals for children in the pediatric intensive care unit (PICU). Researchers will first ask a group of experts to agree on the best methods, then try these methods with a small number of caregivers and hospital staff. The…

This study looks at 200 adults with sick sinus syndrome who need a pacemaker. Researchers want to see if pacing the heart from the Bachmann bundle (a natural electrical pathway) is better for heart health than the usual pacing spot (right atrial appendage). Participants will have…

This study looks at whether the type of anesthesia given during lung cancer surgery can influence whether the cancer comes back. About 5,384 people having surgery to remove non-small cell lung cancer will be randomly assigned to receive either inhaled gas anesthesia or intravenou…