Samsung Medical Center

This study compares a new drug, Zastaprazan, against standard proton pump inhibitors (PPIs) for preventing stomach bleeding in 5,000 adults who had a heart attack and are on blood thinners. The goal is to see if routine use of Zastaprazan reduces serious complications like death,…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study is testing a new way to give radiation therapy (called PULSAR) along with standard chemotherapy and immunotherapy for people with advanced stomach cancer that cannot be removed with surgery. The radiation is given in high doses every few weeks, tailored to each patient…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) in the lungs from growing after surgery for a specific type of lung cancer. About 43 adults with early-stage lung cancer and an EGFR mutation will take a daily pill for one year. The goal is to…

This study tests whether the drug osimertinib can stop or shrink small, hazy lung spots (called ground-glass nodules) that remain after surgery for a type of lung cancer. About 59 adults with EGFR-mutant lung adenocarcinoma will take one pill daily. The goal is to see if the drug…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This early-phase trial tests whether adding the oral drug selinexor to standard chemotherapy can help people with relapsed or refractory B-cell non-Hodgkin lymphoma that has spread to the central nervous system. About 37 adults will receive the combination to find the safest dose…

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This phase 3 trial compares two types of radiation therapy for men whose prostate cancer has returned after surgery. One schedule takes 5-6 weeks, while the other is completed in just 2 weeks. The study aims to see if the shorter option works just as well with manageable side eff…

This study compares a newer pacemaker method, left bundle branch area pacing (LBBAP), to the standard right ventricular pacing in 200 patients with heart block and normal heart function. The goal is to see if LBBAP better preserves the heart's pumping ability and reduces complica…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This phase 2 trial is testing a shorter course of radiation therapy (hypofractionated IMRT) given alongside chemotherapy (cisplatin) for cervical cancer. The goal is to see if this approach can reduce the overall treatment time from the usual 7-8 weeks while still controlling the…

This phase 2 trial tests whether combining two targeted drugs—lazertinib and tepotinib—can shrink tumors in people with advanced EGFR-mutant non-small cell lung cancer whose disease has worsened after initial lazertinib treatment due to MET gene changes. About 47 participants wil…

This study tests whether a stronger blood thinner (prasugrel) combined with aspirin works better than the standard combo (clopidogrel plus aspirin) in heart disease patients undergoing complex artery stenting. About 3,500 adults will be enrolled to see if the stronger combo reduc…

This study compares two endoscopic procedures—argon plasma coagulation (APC) and endoscopic mucosal resection (EMR)—for treating small (1 cm or smaller) precancerous growths in the stomach called gastric adenomas with low-grade dysplasia. About 160 adults will be randomly assigne…

This phase 2 trial is testing whether adding a special type of radiation called adaptive pulse radiotherapy to standard immunotherapy can help treat advanced solid tumors. The study will enroll 35 people who are already receiving or planning to receive immune checkpoint inhibitor…

This study is for adults with severe cardiogenic shock who need a heart-lung machine (ECMO) and have developed acute kidney injury. Researchers want to see if starting dialysis (continuous renal replacement therapy) earlier improves survival and reduces long-term kidney dependenc…

This study looks at whether people who have had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either continue or stop their beta-blocker medication. The goal is to see if …

This study tests a drug called patritumab deruxtecan in adults with advanced solid tumors that have a rare genetic change called an NRG1 fusion. The drug aims to block signals that help these cancers grow. About 30 people will take part to see if the drug can shrink tumors and co…

This phase II trial tests a new radiation technique called PULSAR, which delivers short, powerful proton beam pulses every few weeks, adapted to tumor changes. It is for people with locally advanced or limited metastatic pancreatic cancer who have already had some chemotherapy. T…

This study tests whether a smartphone app that guides rehabilitation exercises can help people recover shoulder function after rotator cuff repair surgery. Seventy adults who have had the surgery will use either the app or receive standard care with a brochure. The goal is to see…

This study looks at whether people with chronic heart disease and a high risk of bleeding can stop taking antiplatelet drugs (blood thinners) one year after a balloon angioplasty procedure. Researchers will compare those who stop versus those who continue the medication, tracking…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach leads …

This phase 2 trial tests whether the immunotherapy drug avelumab can help prevent upper tract urothelial carcinoma from coming back after patients have already received cisplatin-based chemotherapy. About 48 adults with high-risk muscle-invasive or node-positive disease who show …

This study looks at whether a small, wearable continuous glucose monitor (CGM) can accurately diagnose dumping syndrome in people who have had surgery for esophageal cancer. Dumping syndrome happens when food moves too quickly into the small intestine, causing symptoms like dizzi…

This study compares two ways to check heart arteries after a CT scan shows non-severe blockages: an invasive angiogram (a tube in the artery) versus standard non-invasive tests (like stress tests). About 2,000 people with chest pain or related symptoms will be randomly assigned t…

This study tests whether adjusting a pacemaker's lower heart rate to an individual's optimal level can improve symptoms and quality of life in people with heart failure and bradycardia. Researchers will compare this personalized approach to the standard fixed rate of 60 beats per…

This study tests a personalized approach to brain stimulation (rTMS) for people with Parkinson's disease. The goal is to see if tailoring the stimulation to each patient's brain function improves walking better than the standard one-size-fits-all method. The study will involve 60…

This study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…

This study tests whether personalized brain stimulation (rTMS) can improve arm movement in people who had a stroke within the past 3 months. About 120 participants will receive either a tailored treatment based on their brain's recovery potential or a standard approach. The goal …

This study looks at whether features on CT scans can predict how well non-small cell lung cancer responds to chemoimmunotherapy given before surgery. Researchers will compare CT images taken before and after treatment with the actual results from surgery. The goal is to develop a…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study analyzes tumor tissue from 797 people with relapsed small cell lung cancer to identify genetic subtypes. No drugs are tested here. Instead, the results may help match patients to future targeted therapy trials. Participants must have had prior platinum-based chemothera…

This study is collecting data from 250 patients with acute respiratory failure to develop an AI model that groups patients by their characteristics. The goal is to personalize treatment and improve outcomes. It is an observational study, meaning no new drug or device is being tes…

This study is following 81 adults with a rare condition called hemophagocytic lymphohistiocytosis (HLH), where the immune system becomes dangerously overactive. Researchers aim to better understand the disease's features and how patients respond to treatments like steroids and ch…

This large clinical trial is testing whether the type of anesthesia used during lung cancer surgery affects the chances of the cancer coming back. Over 5,000 people having surgery for early-stage non-small cell lung cancer will be randomly assigned to receive either intravenous p…

This study is collecting data from 2,200 children aged 0 to 12 who come to emergency rooms with breathing problems. Researchers will use videos and clinical information to train an artificial intelligence system to automatically recognize different breathing patterns. The goal is…

This study is developing and testing a new way to set recovery goals for children in the pediatric intensive care unit (PICU). The method, based on the Canadian Occupational Performance Measure (COPM), focuses on what matters most to the child and their family. Researchers will f…

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma (a type of cancer in the kidney or ureter) to monitor for cancer recurrence. Participants will receive standard treatment (chemotherapy before surgery to remove the kidney and ureter) and provid…

This study looks at 200 adults with sick sinus syndrome who need a pacemaker. Researchers will compare two places to put the pacing wire—Bachmann's bundle or the right atrial appendage—to see which one better prevents heart damage. The goal is to learn which site leads to healthi…

This study looks at whether a follow-up CT scan of the heart's arteries (coronary CT angiography) one year after stent placement can reduce major heart problems like heart attacks or death compared to usual care. It will enroll 3,500 high-risk patients who have had stents placed …

This study is analyzing blood and tumor samples from 30 people with advanced head and neck cancer who are receiving standard immunotherapy plus chemotherapy. The goal is to find biological markers that can predict who will respond well to treatment. By understanding changes in th…

The HOPE study is a long-term research project at Samsung Medical Center that will follow about 350 head and neck cancer patients each year. Researchers will collect medical information, tumor tissue, and blood samples to understand how the disease progresses and why some patient…

This study is testing whether a special type of PET-CT scan (F-18 FDG PET-CT) can better track how well treatment is working in people with advanced breast cancer compared to standard imaging like CT scans. Researchers will follow 100 patients for 48 weeks after they start their …

This study is collecting tissue and blood samples from 1,730 people with early gastric cancer or precancerous stomach growths. Researchers will analyze the genetic profiles of these samples to find markers that could help diagnose these conditions early and predict if the cancer …