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Which ablation method best tames persistent AF? a Head-to-Head trial aims to find out

NCT ID NCT07726901

Recruiting now Disease control Sponsor: Samsung Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial compares two catheter ablation strategies for people with persistent atrial fibrillation (AF). One group receives standard pulmonary vein isolation using pulsed-field ablation; the other receives radiofrequency ablation followed by additional map-guided targeting of abnormal heart tissue. Researchers will track which approach better prevents atrial arrhythmias over one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
catheter ablation (pulsed-field ablation or radiofrequency ablation with map-guided substrate modification)
What this could lead to
If one strategy proves superior, it could establish a more effective standard approach for treating persistent atrial fibrillation, potentially reducing recurrence and the need for repeat procedures.
What could go wrong
This is a single-center trial, and results may not apply to all patients. Both procedures carry risks such as bleeding, heart damage, or arrhythmia recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Samsung Medical Center

    NOT_YET_RECRUITING

    Seoul, Seoul, 06351, South Korea

  • Samsung Medical Center

    RECRUITING

    Seoul, Seoul, 06351, South Korea

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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