ATRIAL FIBRILLATION (AF)

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful heart ablation procedure. About 4,100 adults who have been free of AF for at least 2 months after ablation will either stop or continue their blood thinner. E…

This study tests whether using a non-invasive body-surface map to guide catheter ablation can better treat atrial fibrillation (AF) compared to the standard approach. About 45 adults with persistent AF and an enlarged left atrium will receive a personalized ablation based on this…

This study tests a new catheter system (Sphere-9 and Affera) for a repeat heart ablation procedure in people whose atrial fibrillation (AFib) came back after a first ablation. About 400 adults with recurrent symptomatic AFib will get the procedure and be followed for 12 months to…

This study looks at whether a procedure called catheter ablation can help people with persistent atrial fibrillation (an irregular heartbeat) who also have severe mitral regurgitation (a leaky heart valve). The goal is to see if ablation reduces the leakiness better than medicati…

This study tests whether a new medication, AP31969, can reduce the amount of time people with atrial fibrillation (AF) spend in an irregular heart rhythm. About 200 adults with AF will receive either AP31969 or a placebo pill for several weeks. The main goal is to see if the drug…

This study looks at two ways to treat atrial fibrillation (an irregular heartbeat) in people who also have heart failure with preserved heart function. Participants will be randomly assigned to either a procedure called catheter ablation to restore normal rhythm, or medications t…

This study tests whether the drug dapagliflozin, typically used for diabetes, can reduce the return of atrial fibrillation (an irregular heartbeat) after a procedure called cardioversion. About 1600 adults with AFib will take either dapagliflozin or no extra drug for up to 56 day…

This study looks at whether re-sterilized catheters are as safe and effective as new ones for a common heart procedure called pulmonary vein isolation in people with atrial fibrillation. About 200 adults will be randomly assigned to receive either a new or a reprocessed catheter …

This study tests whether adding an AI-powered mapping system (vMap) to the standard heart ablation procedure helps treat atrial fibrillation (AF) better than ablation alone. About 423 adults with persistent or recurrent AF will be randomly assigned to one of two groups. The goal …

This study tests whether a 12-month program of tailored exercise and dietary changes can reduce the amount of time spent in atrial fibrillation (an irregular heart rhythm) and decrease fat around the heart in overweight and obese adults. About 158 participants with atrial fibrill…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent blood clots in people with atrial fibrillation (an irregular heartbeat). About 1,200 participants will receive one of the new drugs or the standard blood thinner apixaban. The main goal is to see if the ne…

This study tests if a newer pacemaker method (left bundle branch pacing) can reduce the time spent in fast heart rate episodes compared to standard pacing. About 244 adults who need a pacemaker for heart block and have normal heart function will be randomly assigned to one of the…

This study compares a new procedure called electroporation (using targeted electrical pulses to fix heart rhythm) against standard medication for people with early atrial fibrillation and heart failure. 200 participants will be randomly assigned to either the procedure or medicat…

This study tests a device called AtriLASH that closes a small heart pouch (left atrial appendage) during planned heart surgery in 200 adults with atrial fibrillation. The goal is to reduce stroke risk and possibly allow some patients to stop taking blood thinners long-term. The m…

This study tests a monthly injection called abelacimab to prevent strokes in about 1,900 people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard oral blood thinners. Participants will receive either the study drug or a placebo. The goal is to see …

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF that hasn't improved with medication will receive the procedure. The goal is to safely restore normal heart rhythm and re…

This study tests if closing off a small pouch in the heart (the left atrial appendage) with a device is better than taking blood thinners for people with an irregular heartbeat (atrial fibrillation) who have already had a brain bleed. Both approaches aim to prevent strokes, but b…

This study looks at whether starting treatment early for hidden atrial fibrillation (a type of irregular heartbeat) can reduce the amount of time the heart is in this rhythm. About 520 adults with heart devices that detect these hidden episodes will be split into two groups: one …

This study tests a new approach for people with atrial fibrillation (an irregular heartbeat) who receive a heart stent. Instead of taking multiple blood thinners together for months, participants will take just one drug at a time: an antiplatelet for the first month, then a diffe…

This study tests whether giving extra fluids through an IV before and after a new type of heart procedure (pulsed field ablation) can prevent kidney injury in people with atrial fibrillation. About 290 adults will be randomly assigned to receive either standard care or extra flui…

This study tests whether a type of diabetes medication (SGLT2 inhibitors) can improve the heart's upper chamber function and help prevent heart failure in people with intermittent atrial fibrillation, high blood pressure, and abnormal blood sugar. About 66 adults will receive eit…

This study compares two heart procedures for people with persistent atrial fibrillation (AF), a condition where the heart beats irregularly. Both procedures use pulsed field ablation to destroy small areas of heart tissue causing the problem. One group gets standard treatment plu…

This study tests doing two heart procedures at the same time in people with atrial fibrillation (AF) who are at high risk for stroke but cannot take long-term blood thinners. The combined approach uses a special type of energy (pulse field ablation) to fix the heart's electrical …

This study is testing a new way to pace the heart called left bundle branch area pacing (LBBAP) in 200 people with conditions like slow heartbeat, heart failure, or atrial fibrillation. The goal is to see if this method is safe and works better than standard pacing over 6 months.…

This study looks at whether a procedure called catheter ablation (which uses heat or cold to fix irregular heartbeats) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ab…

This study looks at a new circular-shaped catheter that uses pulsed energy to treat atrial fibrillation and atrial flutter. It is guided by a special ultrasound inside the heart to improve accuracy. Researchers want to see if it can safely and effectively restore normal heart rhy…

This study checks if a special blood pressure monitor (TH-75) can accurately detect atrial fibrillation, a common heart rhythm problem. About 392 adults with and without atrial fibrillation will use the monitor, and its results will be compared to a standard heart test. If accura…

This study tests an artificial intelligence system that analyzes electrocardiograms (ECGs) to alert doctors when a patient might have hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 14,700 adults who have had an ECG in the past year w…

This study looks at whether a small, wireless heart sensor patch worn for up to 14 days can find an irregular heartbeat (atrial fibrillation) better than the usual 24-48 hour hospital monitor in people who recently had a stroke. About 450 adults who had a stroke or mini-stroke in…

This study compares two ways of checking heart rhythm after a procedure called TAVI (replacing a heart valve without open surgery). Half of the 250 participants will wear a portable ECG monitor for 30 days, while the other half get the usual short hospital monitoring. The goal is…

This study tests if placing a biodegradable patch soaked with the drug amiodarone directly on the heart during surgery can prevent a common complication called atrial fibrillation. About 500 adults having planned heart surgery will take part. The patch is designed to deliver the …

This study tests a new device called the AccuSafe guidewire against the usual needle for a key step in treating atrial fibrillation (an irregular heartbeat). The goal is to see if the guidewire makes the procedure safer, faster, and reduces the need for X-rays. About 144 adults w…

This study looks at whether a procedure called catheter ablation can improve quality of life in people aged 80 and older who have atrial fibrillation (an irregular heartbeat). Participants will be randomly assigned to receive either the real procedure or a sham (fake) procedure. …

This study tests whether a short exercise program before a common heart procedure (catheter ablation) can help people with atrial fibrillation recover better. One hundred adults aged 18-70 will be randomly assigned to either the exercise program or usual care. Researchers will me…

This study tests whether a 12-week digital yoga program called MediYoga can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get online support. The goal is to see if this…

This study tests a personalized approach to treat atrial fibrillation (AFib) using a special mapping system to guide a heart procedure called catheter ablation. The goal is to see if this tailored method works better than the standard approach at stopping AFib and preventing it f…

This study tests a newer catheter for treating atrial fibrillation (an irregular heartbeat) that may eliminate the need for a pre-procedure CT scan, reducing radiation and costs. About 58 adults with AF who are candidates for ablation will be randomly assigned to the new or stand…

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to learn how often AF returns and whether the cause (heart surgery, other surgery…

This study looks at whether adding routine physical health checkups to mental health care helps find hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults in Denmark will get these screenings, and their results w…

This study aims to understand what keeps atrial fibrillation (AFib) going in the heart. Researchers will use special mapping to find problem areas and test if burning them (ablation) helps. About 78 adults with long-lasting AFib or dangerous ventricular arrhythmias will take part…

This study looks at sleep quality in 100 people with atrial fibrillation who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four sleep tests (two before and two after the procedure) to measure breathing and heart rate during sleep. The…

This study tests whether a smartwatch and a digital platform can help doctors detect heart rhythm problems like atrial fibrillation early in people with heart disease. About 520 adults will wear a smartwatch and sometimes a portable heart monitor for up to 45 days. The goal is to…

This study is tracking 30,000 people aged 60 and older in rural China to see if a comprehensive program—combining medication, lifestyle advice, education, and heart monitoring—can lower the risk of heart attacks, strokes, and heart-related deaths. Participants will be followed fo…

This study looks at whether drinking alcohol increases the chance of atrial fibrillation (AFib) episodes in people with a come-and-go form of the condition. One hundred participants will be randomly assigned to drink or avoid alcohol on different days while wearing heart monitors…

This study collects information from 1,000 people who have had or will have a heart rhythm test or treatment at University Hospital Düsseldorf. The goal is to see how safe and effective these standard procedures are in everyday care. No new treatments are being tested; instead, r…

This study aims to find out if certain genetic differences make some people with atrial fibrillation (an irregular heartbeat) more likely to develop a weakened heart muscle (cardiomyopathy). Researchers will compare the DNA of 299 adults with and without this condition. The goal …

This study is testing whether certain heart ultrasound results can identify people who have undiagnosed atrial fibrillation (an irregular heartbeat). About 3,000 participants with specific ultrasound findings will be randomly assigned to receive extended heart monitoring or usual…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in people with a type of irregular heartbeat called paroxysmal atrial fibrillation. Researchers will measure changes in heart function using ultrasound during the procedure. The…

This study tests whether doing a special heart CT scan in the emergency department can help people with atrial fibrillation (a fast, irregular heartbeat) get treated faster and avoid being admitted to the hospital. About 190 participants will either get the CT scan and immediate …

This study tests a new catheter (OPTRELL™) that creates detailed maps of the heart to find the exact spots causing persistent atrial fibrillation (AFib). About 80 adults with long-lasting AFib will receive this mapping-guided ablation. The goal is to see if targeting these specif…

This study looks at why some people with persistent atrial fibrillation (a common heart rhythm problem) don't get lasting relief from standard ablation treatment. Researchers will create detailed 3D maps of the heart's electrical activity and scar areas during the procedure. By t…

This study watches 40 adults with atrial fibrillation who get a new heart procedure called pulsed field ablation. The goal is to see if tiny, symptomless spots appear on brain scans afterward. Researchers want to learn how safe this new technique is for the brain.

This study follows 1,200 people with atrial fibrillation (AF) in China who are getting a new type of heart procedure called pulsed field ablation. The goal is to see if early heart rhythm issues after the procedure can predict long-term problems. Participants will have regular ch…

This study is testing whether a wearable, AI-enhanced heart monitor worn for 7 days can find more cases of atrial fibrillation (an irregular heartbeat that raises stroke risk) than usual care in people aged 60 and older living in rural China. About 15,360 participants from 128 vi…

This study looks at whether a night of poor sleep can trigger heart rhythm problems like atrial fibrillation (AFib) in people with sleep apnea. About 100 adults with a sleep apnea device will wear a heart monitor for 14 days. Researchers will compare days after good sleep versus …

This study looks at whether using a 7-day heart monitor can find hidden atrial fibrillation (an irregular heartbeat) in people with higher levels of a heart stress marker called NT-proBNP. About 4,000 adults aged 40 and older without known AF will be split into two groups: one ge…

This study looks at how well and how safely a new catheter (Varipulse) can treat atrial fibrillation by using pulsed-field energy to burn specific areas in the heart. About 50 adults with non-paroxysmal atrial fibrillation will take part. The main goals are to see if the burning …