ATRIAL FIBRILLATION (AF)

This global trial compares two ablation strategies for people with persistent atrial fibrillation (AF) that hasn't responded to medication. One group gets standard ablation of the pulmonary veins and back wall of the left atrium. The other group gets ablation guided by a special …

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a new way to guide catheter ablation for atrial fibrillation (AF), a common heart rhythm problem. The technique uses unipolar voltage mapping to find specific electrical signals (QS potentials) that may help keep AF going. Researchers will compare this personaliz…

This Phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. Two hundred adults with paroxysmal or persistent AF will receive either AP31969 or a placebo twice daily for several we…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful catheter ablation procedure. About 3,160 adults who have been free of AF for 6 to 12 months after ablation will be randomly assigned to either continue or sto…

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF will receive the procedure to see if it safely restores a normal heartbeat. The goal is to improve symptoms and quality o…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This study looks at whether pulsed field ablation (PFA), a standard treatment for atrial fibrillation, creates lasting changes in the heart's electrical pathways. Researchers will check this during a follow-up procedure to close the left atrial appendage, and may do extra ablatio…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study compares a new procedure called pulsed field ablation (PFA) to standard treatment for atrial fibrillation, a common heart rhythm problem that raises stroke risk. About 1,574 adults who need catheter ablation will be randomly assigned to receive PFA or standard care. Th…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study compares a new pulsed field ablation (PFA) catheter to standard heat or cold ablation for atrial fibrillation (AF). About 136 adults with AF will be randomly assigned to one of the two methods. Researchers will check if the new approach is as good at preventing irregul…

This study tests a new approach for people with atrial fibrillation who have just received a coronary stent. Instead of taking multiple blood thinners together for months, the experimental group takes only one antiplatelet drug for the first month, then switches to a single antic…

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study is testing a new type of heart pacing lead that is placed in the left bundle branch area, a key part of the heart's electrical system. The goal is to see if this approach is safe and works better than standard pacing for people with bradycardia (slow heart rate) or hea…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study tests a monthly injection called abelacimab to prevent strokes in about 1,900 people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard oral blood thinners. Participants will receive either the drug or a placebo, and researchers will trac…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests doing two heart procedures at the same time for people with atrial fibrillation (AFib) who cannot take long-term blood thinners. The first procedure uses pulse field ablation to fix the heart's faulty electrical signals. The second closes off a small pouch in the…

This study tests whether adding an AI-powered heart mapping system (vMap) to the standard ablation procedure helps treat atrial fibrillation (AF) better than ablation alone. About 423 adults with persistent or recurrent AF will be randomly assigned to either standard treatment or…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study compares two ways of placing a pacemaker lead in people who need frequent pacing. One method (left bundle branch pacing) aims to activate the heart more naturally than the standard method. The goal is to see if it reduces the time the heart spends in fast, irregular rh…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful heart ablation procedure. About 4,100 adults aged 18-80 who have been on blood thinners for at least 2 months after ablation and have no signs of AF recurrenc…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants will either follow the lifestyle …

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study tests two ways to manage atrial fibrillation in people with heart failure: using a procedure called catheter ablation to restore normal rhythm, or using medications to control heart rate. About 84 participants will be randomly assigned to one of these approaches. The g…

This study compares reprocessed (cleaned and re-sterilized) ablation catheters to brand-new ones in 200 adults with atrial fibrillation undergoing pulmonary vein isolation. The goal is to see if the reused catheters are just as safe and effective, while also being cheaper and bet…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study tests a new circular-shaped catheter that uses pulsed field energy to treat atrial fibrillation and atrial flutter. About 150 adults will receive the procedure, guided by ultrasound inside the heart. The goal is to see if the catheter safely and effectively blocks abno…

This study tests a device called AtriLASH that closes a small heart pouch (the left atrial appendage) during planned heart surgery in 200 people with atrial fibrillation. The goal is to prevent blood clots that cause strokes, potentially reducing the need for blood-thinning medic…

This pilot study tests whether using a noninvasive global mapping system to guide catheter ablation can improve outcomes for people with persistent atrial fibrillation. Thirty participants will receive standard pulmonary vein isolation plus personalized ablation of up to three ad…

This pilot study tests whether a non-invasive global mapping system can help doctors personalize catheter ablation for people with persistent atrial fibrillation (AF). The standard approach isolates the pulmonary veins, but this study adds up to three extra targets based on where…

This study tests whether dapagliflozin, a drug typically used for diabetes, can prevent atrial fibrillation from coming back after a procedure called cardioversion (an electric shock to restore normal heart rhythm). About 1600 adults with AF will take either dapagliflozin or no e…

This study tests a new catheter called OPTRELL™ to map and treat persistent atrial fibrillation (AF), a type of irregular heartbeat that is harder to treat. The device helps doctors identify and target the specific areas in the heart causing the problem. The trial will enroll 80 …

This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to …

This study compares a new wearable armband called HeartWatch to the standard Holter monitor for detecting heart rhythm problems like atrial fibrillation. About 300 adults who need a Holter test will wear both devices at the same time. The goal is to see if the HeartWatch can accu…

This study tests whether a special CT scan done in the emergency department can quickly check for blood clots in people with atrial fibrillation or atrial flutter. If no clot is found, doctors can proceed with a procedure to restore normal heart rhythm (cardioversion) right away.…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing whether a special blood pressure monitor can accurately detect atrial fibrillation, a common heart rhythm disorder. Researchers will compare the monitor's readings with standard diagnostic methods in 392 adults, some with and some without AF. If it works, th…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study is testing whether certain heart ultrasound findings can identify people who might have hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. Researchers will enroll 3000 participants with abnormal ultrasound results and randomly assig…

This study tests whether an artificial intelligence (AI) system can help doctors spot hidden atrial fibrillation (AF) — a common heart rhythm disorder that raises stroke risk — by flagging suspicious electrocardiograms (ECGs). About 14,700 patients will be randomly assigned to ha…

This study tests whether placing a biodegradable patch soaked with the drug amiodarone on the heart during surgery can prevent atrial fibrillation (a common irregular heartbeat) afterward. About 500 adults having elective heart surgery will be randomly assigned to get either the …

This study compares a new guidewire (AccuSafe) to the standard needle used to cross the heart wall during catheter ablation for atrial fibrillation. The goal is to see if the guidewire is safer and more effective, especially when done without X-ray guidance. 80 patients will be r…

This study compares a new second-generation catheter (FARAWAVE Nav) used without a pre-procedure CT scan to the standard approach with a CT scan for treating atrial fibrillation. The goal is to see if the new method reduces radiation exposure and procedure time. 58 adults with at…

This study looks at whether a procedure called catheter ablation can improve quality of life for people aged 80 and older who have a heart rhythm problem called atrial fibrillation. Half of the 182 participants will get the real procedure, and half will get a fake one (sham) to s…

This study tests whether a 12-week digital MediYoga program—combining deep breathing, gentle yoga, and meditation—can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get …

This study tests whether a 4-week program of exercise and psychological education before catheter ablation for atrial fibrillation can improve heart fitness and reduce arrhythmias after the procedure. About 100 adults aged 18-70 scheduled for their first ablation will be randomly…

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This study looks at whether a person's genetic makeup can help spot undiagnosed atrial fibrillation (AF), an irregular heartbeat that raises stroke risk. About 800 adults with symptoms or risk factors will wear a heart monitor for 7 days and use a handheld ECG device at home for …

This study aims to find unique substances in the blood (biomarkers) that are only present in people with atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from 400 patients with AF to those without, and track changes over time. The goal is…

This study is a registry that will follow 4,000 people in China who are having a procedure called catheter ablation to treat atrial fibrillation or ventricular tachycardia. The goal is to see how well the procedure works over the long term and how safe it is. Participants will be…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study compares two catheters used during a common heart procedure for atrial fibrillation. The goal is to see if one catheter can confirm that the treatment worked faster than the current method. Thirty adults with persistent atrial fibrillation or atrial flutter will be enr…

This observational study looks at why women with atrial fibrillation (AF) tend to have higher recurrence rates after standard ablation. Researchers will map the heart's electrical activity in 100 patients right after routine pulmonary vein isolation to find extra trigger spots th…

This study will follow 2,500 elderly people (ages 65-80) in rural China who have atrial fibrillation, a common heart rhythm problem. Researchers will screen them for heart failure using blood tests and heart ultrasounds, then check on them every three months to see how their cond…

This study investigates whether certain genetic variations make some people with atrial fibrillation more likely to develop a weakened heart muscle (cardiomyopathy). Researchers will compare the DNA of 299 participants, including those with AF-related cardiomyopathy and control g…

This study follows 1,200 people in China with atrial fibrillation who are getting a new type of procedure called pulsed field ablation. Researchers want to see if early heart rhythm problems after the procedure can predict if the condition will come back later. Participants will …

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in 50 people with paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use ultrasound images taken during the procedure to measure changes in heart f…

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to see how often AF returns and whether the cause (heart surgery, other surgery, …

This study looks at whether a night of disrupted sleep can lead to extra heartbeats or atrial fibrillation the next day. Researchers will ask 100 adults with sleep apnea to either use or not use their sleep device on different nights, then monitor their heart rhythms. The goal is…

This study watches 40 adults with atrial fibrillation who get a new type of heart treatment called pulsed field ablation. The goal is to see if the procedure causes tiny, symptom-free brain spots that show up on MRI scans. Researchers want to know how often these spots happen and…

This study is testing whether sending a portable ECG monitor to people with elevated NT-proBNP (a heart stress marker) can catch hidden atrial fibrillation and reduce strokes. 4,000 adults aged 40+ without known AF will be randomly assigned to either 7 days of home monitoring or …

This study compares a 7-day AI-enhanced single-lead ECG patch against routine 12-lead ECGs to detect new atrial fibrillation in 15,360 adults aged 60+ in rural China. The goal is to see if longer, smarter monitoring catches more cases and reduces deaths, strokes, and heart failur…

This study looks at whether avoiding alcohol reduces the chance of an atrial fibrillation (AFib) episode in people with paroxysmal AFib. One hundred participants will be randomly assigned each day to either avoid or be allowed to drink alcohol. They will wear heart monitors, fitn…

This study looks at sleep quality in 100 people with atrial fibrillation (AFib) who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests—two before and two after the procedure—to measure breathing, heart rate, a…

This study looks at how well and how safely a new catheter (Varipulse) works for treating a type of irregular heartbeat called atrial fibrillation. About 50 adults with this condition will receive the procedure. Researchers will check if the treatment successfully blocks faulty e…

This study at St Bartholomew's Hospital is enrolling 160 people with persistent atrial fibrillation (AFib) who are scheduled for their first catheter ablation. Researchers will create detailed 3D electrical maps of the heart during the procedure to understand why AFib persists an…

This registry collects information from 1,000 patients who have had or will have a heart rhythm procedure at University Hospital Düsseldorf. The goal is to track safety and success of these standard procedures in everyday care. No new treatments are being tested; instead, researc…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study will follow 30,000 people aged 60 and older in rural China for up to 10 years. Researchers want to see if a comprehensive program—including medication, lifestyle changes, health education, and regular check-ups with a 7-day heart monitor—can lower the number of heart a…