ATRIAL FIBRILLATION (AF)

This study is testing a new method to guide ablation, a procedure that uses heat or cold to create tiny scars in the heart to stop irregular rhythms. Researchers will use advanced mapping technology to identify specific, stable areas believed to drive persistent atrial fibrillati…

This large study is testing if people who have had a successful procedure to fix an irregular heartbeat (atrial fibrillation) can safely stop taking daily blood-thinning medication. It will compare the risks of stroke and serious bleeding between people who stop the medication an…

This study is testing whether a personalized 12-month program of exercise and dietary changes can help reduce episodes of atrial fibrillation (AFib) in overweight and obese adults who have this common heart rhythm disorder. Researchers will compare the program to usual medical ca…

This study is testing whether a new high-density mapping catheter called OPTRELL can better identify the specific areas in the heart that cause persistent atrial fibrillation (AF). Researchers will use this mapping to guide radiofrequency ablation, a procedure that creates small …

This study compares two methods of using pulsed electrical energy to treat persistent atrial fibrillation, a common heart rhythm disorder. It will test whether a newer approach that maps extra electrical sources in the heart is as safe and effective as the standard method that al…

This study is testing if a heart procedure is better than standard medication for people who have both an irregular heartbeat (atrial fibrillation) and a specific type of heart failure. The procedure uses electrical pulses to isolate problem areas in the heart. Researchers will c…

This study is testing the safety and performance of two specific heart pacing leads when placed in a particular area of the heart's electrical system. Researchers will follow 200 adult patients for 6 months after implant to check for complications like infection, lead movement, o…

This study aims to see if starting treatment early for a hidden type of atrial fibrillation (AF) can better control the condition. It will enroll 520 adults who have a heart device that detected AF but who haven't had it confirmed on a standard heart test. Participants will be ra…

This study is testing two new experimental drugs, REGN7508 and REGN9933, which are injectable antibodies designed to prevent blood clots in people with atrial fibrillation (AFib). It will compare their safety, especially the risk of bleeding, against the commonly used blood thinn…

This study is testing if a special 4-week training and education program before a heart procedure helps people with atrial fibrillation recover better. It will compare 100 patients who do the pre-surgery program to those who get standard care. The main goals are to see if the pro…

This study is testing whether a new injectable drug called abelacimab can safely prevent strokes and blood clots in people with atrial fibrillation who are at high risk but cannot take standard oral blood thinners. About 1,900 participants will receive either the drug or a placeb…

This study compares two catheters used to treat atrial fibrillation (AFib), an irregular heartbeat. The goal is to see if a newer, second-generation catheter can work just as well without requiring a CT scan before the procedure. Researchers want to know if this new approach redu…

This study is testing whether re-sterilized catheters used in a heart procedure for atrial fibrillation are as safe and work as well as brand-new ones. About 200 adult patients scheduled for the procedure will be randomly assigned to have it done with either a new or a re-sterili…

This pilot study is testing a more personalized approach to catheter ablation for persistent atrial fibrillation (AF), an irregular heartbeat. Researchers are using a noninvasive mapping system to identify specific areas in the heart that may be driving the AF, then targeting tho…

This study is testing whether a newer method of placing a pacemaker wire, called left bundle branch pacing, is better than the standard method at reducing episodes of fast, irregular heart rhythms. Researchers will compare the two techniques in 244 patients who need a pacemaker f…

This study is testing a new medical device that uses brief, targeted electrical pulses to treat atrial fibrillation, a common type of irregular heartbeat. The goal is to see if the device is safe and effective at controlling the condition in people whose symptoms haven't improved…

This study is looking at the safety and effectiveness of performing two heart procedures at the same time. It combines a treatment to fix an irregular heartbeat (atrial fibrillation) with a device to close off a part of the heart to prevent strokes. The research is focused on pat…

This pilot study is comparing two common treatment approaches for people who have both atrial fibrillation (an irregular heartbeat) and heart failure with preserved heart function. Participants will be randomly assigned to either have a catheter ablation procedure to try to resto…

This study aims to find the best way to prevent strokes in people with a common heart rhythm problem (atrial fibrillation) who have already suffered a dangerous brain bleed. Researchers are comparing a one-time heart implant that closes off a small pouch in the heart to long-term…

This study is testing if a diabetes drug called dapagliflozin can help keep a normal heart rhythm after a procedure to fix an irregular heartbeat (atrial fibrillation). Researchers will compare the drug to usual care in 1,600 adults aged 55 and older. Participants will take the p…

This study is testing whether a new, personalized mapping technique can improve catheter ablation for persistent atrial fibrillation (AF). Researchers will use non-invasive mapping to identify specific areas in the heart to target during the procedure, aiming to stop the irregula…

This study is testing a new circular-shaped catheter that uses pulsed electrical energy to treat a specific type of abnormal heart rhythm called atrial flutter. Doctors will use a small ultrasound camera inside the heart to guide the procedure. The main goal is to see if this new…

This study is testing whether using smartwatches and a special digital platform can help doctors monitor heart patients from home. It aims to see if this system can spot irregular heartbeats early and alert doctors quickly. The trial will involve 520 adults with heart conditions,…

This study is comparing two approaches for treating persistent atrial fibrillation (AF), a common irregular heartbeat. Researchers want to see if using an AI mapping system (vMap) along with standard ablation treatment works better than standard ablation alone. About 423 adults w…

This study is testing whether closing a small pouch in the heart during planned heart surgery can safely prevent strokes in people with atrial fibrillation. Researchers will use a special suture device called AtriLASH to seal the pouch where blood clots often form. The goal is to…

This large international study aims to find out if a heart procedure called catheter ablation, combined with standard medications, works better than medications alone for people who have both atrial fibrillation (an irregular heartbeat) and heart failure. It will enroll 1,200 par…

This study is testing whether a comprehensive village-based management program can help elderly people with chronic heart conditions live longer and healthier lives. The program combines medication, lifestyle changes, education, and regular heart monitoring for up to 10 years. Re…

This study aims to improve a common heart procedure called catheter ablation for people with persistent atrial fibrillation (AFib). Researchers will create detailed 3D maps of the heart's electrical activity and scar tissue during the procedure to better understand why AFib retur…

This study is testing if a heart procedure called catheter ablation can improve a severe leaky heart valve in people who also have a persistent irregular heartbeat (atrial fibrillation). Researchers will compare the procedure plus standard medications to medications alone. The ma…

This study is testing a new type of catheter (a thin, flexible tube) used in a procedure to treat persistent atrial fibrillation, a type of irregular heartbeat. The procedure uses pulsed electrical energy to create small scars in specific areas of the heart to block the faulty el…

This trial is testing whether a new oral medication called AP31969 can reduce how often people experience atrial fibrillation (AF) episodes and improve their quality of life. About 200 adults with AF will take either the medication or a placebo pill twice daily for 12 weeks while…

This study aims to find out if certain heart ultrasound measurements can help doctors identify which patients are most likely to have hidden atrial fibrillation (AF), an irregular heartbeat that increases stroke risk. It will enroll 3,000 patients who have abnormal heart scans bu…

This study is testing if smartwatches can find irregular heartbeats (atrial fibrillation) in people who recently had a stroke. Researchers will compare two different smartwatches to a small implanted heart monitor, which is the current best method. The goal is to see if these com…

This study is testing whether an artificial intelligence (AI) system can analyze standard heart tracings (ECGs) to identify patients who might be developing a dangerous irregular heartbeat called atrial fibrillation (AF). Over 14,700 participants will be randomly assigned to eith…

This study is testing whether a small, wireless heart monitor patch worn on the chest for up to 14 days is as good as or better than standard hospital equipment at finding an irregular heartbeat called atrial fibrillation (AF) after someone has had a stroke. About 450 adults who …

This study is testing how well a new home blood pressure monitor can detect atrial fibrillation, a common irregular heart rhythm. It will compare the monitor's readings against standard medical tests to check its accuracy. The goal is to see if this device could help people spot …

This study is testing whether a wearable, AI-powered heart monitor patch worn for a week can find hidden cases of atrial fibrillation (AF) better than standard tests in older adults living in rural China. Finding AF early is crucial because it's a major cause of stroke. The resea…

This study is testing whether placing a special biodegradable patch soaked with a heart medication directly on the heart during surgery can prevent a common and serious irregular heartbeat called atrial fibrillation (AFib) that often occurs after heart surgery. The trial will inv…

This study is testing if a 7-day heart monitor patch can help prevent strokes. It will enroll 4,000 people who have a high level of a specific blood marker but no known heart rhythm problems. Half will wear the monitor to check for a hidden irregular heartbeat (AFib); if found, t…

This study is testing if a 12-week digital yoga program called MediYoga can improve quality of life for people with a common heart rhythm problem called atrial fibrillation (AF). Researchers will enroll 456 participants with AF to see if doing gentle yoga, deep breathing, and med…

This study is testing if a heart procedure called catheter ablation improves quality of life for people aged 80 and older who have symptomatic atrial fibrillation (AF). It will compare the real procedure to a carefully designed fake (sham) procedure to see which group feels bette…

This study aims to understand if a new type of heart procedure for atrial fibrillation (AFib) causes silent, symptomless brain injuries. Researchers will enroll 40 adults with AFib who are getting the new pulsed field ablation (PFA) procedure. They will use brain scans and memory…

This study aims to understand if a single night of disrupted sleep can immediately increase irregular heartbeats in people with sleep apnea. Researchers will temporarily turn off participants' sleep apnea devices on some nights to disrupt sleep, while monitoring their heart rhyth…

This study aims to understand how often atrial fibrillation (an irregular heart rhythm) returns in people who developed it during a serious illness or surgery. Researchers will monitor 100 patients for one year using small implanted heart monitors to track rhythm patterns. The go…

This study is a registry that collects information from patients who undergo specific heart rhythm procedures at University Hospital Düsseldorf. It aims to track the safety, effectiveness, and long-term outcomes of these standard treatments in real-world practice. The data will b…

This study aims to find out if drinking alcohol causes more episodes of an irregular heartbeat called atrial fibrillation (AFib) in people who already have it. For two weeks, 100 participants will be randomly told each day whether to drink or avoid alcohol while wearing several m…

This study aims to understand how a common heart procedure affects sleep in people with atrial fibrillation (AFib). Researchers will monitor the sleep of 100 people with AFib who are scheduled for a pulmonary vein isolation procedure. They will use simple, non-invasive sleep test…

This study aims to understand how a new type of heart procedure, called pulse field ablation, affects the function of the upper heart chambers in people with a specific type of irregular heartbeat (paroxysmal atrial fibrillation). Researchers will use a special ultrasound camera …