New blood thinners aim to cut stroke risk with fewer bleeding side effects

NCT ID NCT07175428

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 6 times

Summary

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Participants will receive one of the study drugs or apixaban, and researchers will monitor bleeding events and side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atrial fibrillation Hemorrhage stroke disorder thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF)

Contacts and locations

Locations

AA Medical Research Center (MRC)
RECRUITING

Flint, Michigan, 48504, United States
Advanced Medical Research
RECRUITING

Maumee, Ohio, 43537, United States
Alpine Research TC
RECRUITING

Clinton, Utah, 84015, United States
Anderson Medical Research
RECRUITING

Ft. Washington, Maryland, 20744, United States
Beth Israel Lahey Health, Beth Israel Deaconess Medical Center (BIDMC)
RECRUITING

Boston, Massachusetts, 02215, United States
Blue Coast Research Center, LLC
RECRUITING

Indianapolis, Indiana, 46237, United States
CHU de Quebec-Universite Laval
RECRUITING

Québec, G1R 2J6, Canada
Cardiologia Assistencial e de Pesquisa Ltda (Cardresearch)
RECRUITING

Belo Horizonte, Minas Gerais, 30150-274, Brazil
Cardiology Associates Medical Group
RECRUITING

Ventura, California, 93003, United States
Cardiovascular Center of Sarasota Foundation for Research and Education
RECRUITING

Sarasota, Florida, 34239, United States
Centre Hospitalier Universitaire De Sherbrooke (CHUS) - Cardiologie
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Centro De Pesquisa Clinica Do Coracao
RECRUITING

Aracaju, Sergipe, 49055-530, Brazil
Centro de Investigacion Clinica
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, 1060, Argentina
Centro de Investigaciones Clinicas del Litoral - Cardiologia
RECRUITING

Santa Fe, S3000FWO, Argentina
Clinical Site Partners, LLC DBA Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
Complete Heart Care P.A.
RECRUITING

McKinney, Texas, 75071, United States
Diex Recherche Inc.
RECRUITING

Sherbrooke, Quebec, J1LOK3, Canada
Diex Recherche Trois-rivieres
RECRUITING

Trois-Rivières, Quebec, G9A 4P3, Canada
Dr James Cha
RECRUITING

Oshawa, Ontario, L1J 2K1, Canada
East Coast Institute for Research, Jefferson City
RECRUITING

Jefferson City, Tennessee, 37760, United States
Eastern Shore Research Institute
RECRUITING

Fairhope, Alabama, 36532, United States
Empire Clinical Research
RECRUITING

Pomona, California, 91767, United States
Faculdade de Medicina de Botucatu (UNESP)
RECRUITING

Botucatu, São Paulo, 18618-687, Brazil
Fairview Health Services
RECRUITING

Maplewood, Minnesota, 55109, United States
Franciscan Physician Network, Indiana Heart Physicians
RECRUITING

Indianapolis, Indiana, 46237, United States
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, Centro Integrado de Pesquisa (CIP)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Fundacion Estudios Clinicos - Cardiologia
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
GA Research Associates Ltd.
RECRUITING

Moncton, New Brunswick, E1G-1A7, Canada
Grady Health System
RECRUITING

Atlanta, Georgia, 30303, United States
Hamilton Health Sciences Corporation
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Hamilton Medical Research Group (HMRG)
RECRUITING

Hamilton, Ontario, L8L 5G4, Canada
Health Sciences Research Building II
WITHDRAWN

Atlanta, Georgia, 30322, United States
Health sciences North - Cardiology
RECRUITING

Greater Sudbury, Ontario, P3E 5J1, Canada
Heart Health Institute Research Inc. - Cardiology
RECRUITING

Scarborough Village, Ontario, M1B 4Z8, Canada
Hospital Ernesto Dornelles
RECRUITING

Porto Alegre, Rio Grande do Sul, 90160-092, Brazil
Hospital Maternidade e Pronto Socorro Santa Lucia
RECRUITING

Poços de Caldas, Minas Gerais, 37706-106, Brazil
Hospital Ruy Azeredo
RECRUITING

Goiânia, Goiás, 74453-200, Brazil
Hospital da Pontificia Universidade Catolica (PUC) Campinas
RECRUITING

Campinas, São Paulo, 13060-904, Brazil
Indiana Medical Research
RECRUITING

Merrillville, Indiana, 46410, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Inpatient Research Clinic LLC
RECRUITING

Miami Lakes, Florida, 33014, United States
Instituto Dante Pazanese de Cardiologia
RECRUITING

São Paulo, 04012-909, Brazil
Instituto De Pesquisa Clinica de Campinas (Ipecc)
RECRUITING

Campinas, São Paulo, 13060-080, Brazil
Instituto de Cardiologia de Santa Catarina
RECRUITING

São José, Santa Catarina, 88103-450, Brazil
Interventional Cardiology Medical Group
RECRUITING

West Hills, California, 91307, United States
K&R Research LLC
RECRUITING

Marion, Ohio, 43302, United States
Mission Cardiovascular Research Institute
RECRUITING

Fremont, California, 94538, United States
Monroe Research, LLC
RECRUITING

West Monroe, Louisiana, 71291, United States
Monument Health Clinical Research
RECRUITING

Rapid City, South Dakota, 57701, United States
Moses Cone Hospital Operating Corporation dba Cone Health, Lebauer-Brodie Center for Cardiovascular Research
RECRUITING

Greensboro, North Carolina, 27401, United States
NSC Research, Inc
RECRUITING

Johns Creek, Georgia, 30024, United States
National Institute of California Heart and Vein Specialists
RECRUITING

Huntington Beach, California, 92648, United States
North Coast Cardiology
RECRUITING

Encinitas, California, 92024, United States
Northbay Clinical Research Center
RECRUITING

Santa Rosa, California, 95405, United States
Nouvelle Clinical Research LLC
RECRUITING

Cutler Bay, Florida, 33189, United States
Nucleo de Pesquisa Clínica SS
RECRUITING

Curitiba, Paraná, 80730-150, Brazil
Nucleo de Pesquisa do Hospital Cardiologico Costantini (NUPEC)
RECRUITING

Belo Horizonte, Minas Gerais, 30220-140, Brazil
Permian Research Foundation
RECRUITING

Odessa, Texas, 79761, United States
PharmaTex Research
RECRUITING

Amarillo, Texas, 79106, United States
Pontificia Universidade Catolica do Paraná (PUC) Trials
RECRUITING

Curitiba, Paraná, 80230-130, Brazil
Profound Research LLC at Southern California Heart Specialists
RECRUITING

Pasadena, California, 91105, United States
Profound Research, Millennium Cardiology
RECRUITING

Farmington Hills, Michigan, 48334, United States
Reid Physician Associates
RECRUITING

Richmond, Indiana, 47374, United States
SEC Clinical Research
RECRUITING

Dothan, Alabama, 36305, United States
STAT Research Argentina
RECRUITING

Buenos Aires, 1060, Argentina
Sociedade Hospitalar Angelina Caron
RECRUITING

Campina Grande do Sul, Paraná, 83430-973, Brazil
South Florida Research Organization LLC
RECRUITING

Medley, Florida, 33166, United States
Synergy Group Medical, LLC
RECRUITING

Missouri City, Texas, 77459, United States
Texas Institute of Cardiology PA
RECRUITING

McKinney, Texas, 75071, United States
Tyler Cardiovascular Consultants
RECRUITING

Tyler, Texas, 75701, United States
University of Alberta Hospital - Cardiology
RECRUITING

Edmonton, Alberta, T6G 2G3, Canada
Valley Clinical Trials, Inc
RECRUITING

Covina, California, 91723, United States
Viacar Recherches Cliniques Inc. - Cardiologie
RECRUITING

Longueuil, Quebec, J4H 4B9, Canada
Victoria Cardiac Arrhythmia Trials
RECRUITING

Victoria, British Columbia, V8Z 0B9, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.