Thrombotic disease

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This study tests whether taking two blood thinners (aspirin and clopidogrel) for 12 months after leg artery surgery is better than taking them for just 1 month in people with severe leg artery disease. The goal is to see if longer treatment prevents amputations or death. About 61…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This trial compares two blood products—prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP)—for controlling bleeding in people undergoing heart valve surgery. Doctors use a special test to guide which product to give and measure how quickly bleeding stops. The goal…

This phase 3 trial is testing two experimental drugs, REGN7508 and REGN9933, to prevent serious blood clots in people with peripheral artery disease who recently had leg surgery to improve blood flow. The study will enroll about 7,050 participants and compare the drugs to a place…

This study tests a new device called the RevCore Thrombectomy Catheter to treat blocked stents in the leg veins. About 100 adults with stents that have been in place for at least 6 weeks will be enrolled. The device is inserted into the vein to remove the blockage and restore blo…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests whether using HEPA air filters at home can slow the progression of heart disease in adults aged 65-84 who have a history of ischemic heart disease. Over 112 participants in Los Angeles will use real or sham filters for several months, and researchers will measure…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests whether a specially adjusted dose of the blood thinner apixaban can safely treat blood clots in cancer patients who also have low platelet counts. About 30 adults with active cancer and a recent clot will receive the adjusted dose. The goal is to see if this appr…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This study tests whether a newer clot-dissolving drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will …

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests whether the blood thinner apixaban can dissolve blood clots in the portal vein that develop more than a year after laparoscopic spleen surgery in people with cirrhosis. Twenty participants will take apixaban twice daily, and doctors will use ultrasound or CT scan…

This study looks at whether the blood thinner apixaban can safely dissolve blood clots in the portal vein (the main vein to the liver) that appear more than a year after spleen removal surgery. It involves 20 adults with cirrhosis who had their spleen removed. The goal is to see …

This study is testing a device called the NeVa stent retriever to see how well it can remove blood clots in people having a severe stroke. The goal is to restore blood flow to the brain in a single pass. The study will enroll 600 adults who are already scheduled to have this proc…

This study looks at whether giving platelet transfusions only when levels are very low can help extremely premature babies (born at 23-26 weeks) survive without major bleeding. About 2,400 infants will be randomly assigned to a lower or higher transfusion trigger. The goal is to …

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. About 600 adults aged 18 to 70 with a specific type of brain bleed will take part. The goal is to see which approach leads to better rec…

This study compares a stent (CARESTO® heal) plus standard medication against medication alone in 536 people who recently had a stroke or retinal artery blockage due to a specific type of carotid artery disease that is not severely narrowed. The goal is to see if the stent can low…

This study looks at 128 people with advanced heart failure who have a HeartMate3 heart pump. All take warfarin to prevent clots, and half will also stop taking aspirin. The goal is to see if skipping aspirin lowers the risk of serious bleeding without raising the chance of danger…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests whether adding batroxobin, a snake venom enzyme that dissolves clots, to standard blood thinners helps people with acute cerebral venous thrombosis (a rare stroke caused by a clot in a brain vein). Seventy-two adults will be randomly assigned to receive either st…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This pilot study tests whether omeprazole, a common heartburn drug, can reduce gastrointestinal bleeding in adults 65 and older who take blood thinners for blood clots. Researchers will enroll 360 participants to see if a larger trial is feasible. The study focuses on recruitment…

This study tests whether using only low-dose blood thinners (instead of the standard full-dose) is safe for patients on a life-support machine called ECMO for severe lung failure. The goal is to see if this approach reduces dangerous bleeding while still preventing clots. Forty a…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests a combination of an experimental immunotherapy (QL1706), a blood vessel blocker (bevacizumab), and chemotherapy given directly into the liver artery for people with advanced liver cancer that has caused a clot in the main portal vein. The goal is to see if this a…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests a new drug called TBO-309, which helps prevent blood clots, in people having a stroke. It is given alongside standard treatments like clot-busting drugs or mechanical clot removal. The main goal is to see if it is safe, especially regarding bleeding in the brain,…

This study tests a drug called Fortelyzin, which is injected directly into blood clots to dissolve them, in people with acute limb ischemia (sudden loss of blood flow to a limb). The goal is to see if it can prevent amputation as well as or better than standard surgery. About 170…

This study tests whether apixaban (a pill taken twice a day) is a safe and more satisfying alternative to enoxaparin (a daily shot) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery. Researc…

This study compares two ways to repair a common type of meniscus tear in the knee. One group gets standard stitches, the other gets stitches plus a fibrin clot made from the patient's own blood to help healing. The trial will enroll 120 people aged 18-50 and check if the meniscus…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during liver transplant surgery. The device measures blood clotting in real time. Researchers hope it will reduce bleeding and the amount of blood products needed. The…

This pilot study tests the blood thinner Rivaroxaban in 10 Chinese children who developed giant coronary artery aneurysms after Kawasaki disease. The goal is to see if a specially adjusted dose can prevent new blood clots in the heart arteries while keeping bleeding risks low. Ch…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study tests a new PET scan that uses a special tracer to find blood clots inside the heart. It involves 20 people with cardiac amyloidosis and atrial fibrillation. The goal is to see if this scan can spot clots better than current methods, which could help prevent strokes.

This study uses a new type of CT scan (photon counting CT) to detect blood clots caused by central venous catheters. Researchers will first scan deceased patients who have a catheter and compare the results to an autopsy. Then they will scan living patients with a catheter to see…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study is testing a new blood test called Cryocheck HexLA to see if it can detect lupus anticoagulant (LA) more accurately than current tests. Researchers will compare the new test with standard tests using blood samples from 200 adults. The goal is to find a test that is bot…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study tests a small, battery-powered device called ClotChek™ that measures how fast a patient's blood clots using a fresh drop of blood. Researchers want to see if it can tell the difference between people on common blood thinners (rivaroxaban or apixaban) and those not on a…

This study looks at the best way to prevent blood clots in people who have a leg cast or splint after an injury. For those at high risk of clots, it compares pills to standard injections. For low-risk people, it checks if any medication is better than just advice. Over 10,000 par…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study from the National Human Genome Research Institute aims to better understand Congenital Disorders of Glycosylation (CDG), a group of rare genetic conditions that affect how the body attaches sugars to proteins and fats. Researchers will examine up to 200 participants, i…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This observational study will follow 1300 critically ill adults in intensive care to see if a blood test called anti-factor Xa activity can predict dangerous blood clots (deep vein thrombosis or pulmonary embolism). Researchers will also track bleeding risks, quality of life, and…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is tracking 2000 patients with moderate to severe pulmonary embolism (blood clots in the lungs) who undergo a procedure called computer-aided vacuum thrombectomy, where a special tube sucks out the clot. Researchers want to see how well the procedure works and what com…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study is collecting blood and urine samples from 150 cancer patients who have had blood clots. The goal is to learn more about why clots happen in cancer and how to prevent them. Participants will be followed over time to track clot recurrence and bleeding risks.

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers understand blood vessel and immune system diseases. Participants give about 10 tablespoons of blood at the NIH Clinical Center and may return for up to 10 years. The samples will be …

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study looks at two different methods (one-needle vs two-needle) for placing a PICC line, a long-term IV used for treatments like chemotherapy. About 284 adults who need a PICC for the first time will take part. The goal is to find out which method leads to fewer complication…

This study is collecting blood samples from 35 adults with a type of blood cancer called myeloproliferative neoplasm (MPN) who have a specific genetic mutation (CALR). Researchers want to understand why patients with a different mutation (JAK2) have a higher risk of dangerous blo…

This study looks at people who use nitrous oxide (laughing gas) for fun, some with and some without nerve problems like trouble walking or numbness. Researchers want to find blood markers that show how the gas harms the body, which could lead to better monitoring and care. About …

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study is creating a global registry of 500 adults with antiphospholipid syndrome (APS) who are taking direct oral anticoagulants (DOACs) like rivaroxaban or apixaban. Researchers will track rates of recurrent blood clots and bleeding over at least 6 months. The goal is to ga…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This early-stage study tests the safety of a new drug called CAY001 in 24 healthy adults aged 18-50. Participants receive a single dose of the drug or a placebo by IV, and researchers monitor them for 28 days for side effects and how the drug moves through the body. The goal is s…

This study follows 2000 people with severe liver-related high blood pressure who receive a TIPS procedure, which creates a bypass in the liver. Researchers will track survival, need for liver transplant, and complications like confusion or liver failure over 12 months. The goal i…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study looks at how blood clotting works differently in the liver's portal vein compared to the rest of the body in people with liver cirrhosis. Researchers will take blood samples from 45 patients during a routine procedure called TIPS, which helps relieve high blood pressur…

This study is a large registry that collects health information from up to 200,000 people with blood disorders such as hemophilia, thrombosis, and sickle cell disease. Participants are seen at Hemophilia Treatment Centers across the U.S. The goal is to gather real-world data to h…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study aims to learn how platelets—blood cells that help with clotting and healing—work in healthy people over time. Researchers will collect blood samples and health information from 400 volunteers aged 18 and older every 6 to 7 months for up to 10 years. The goal is to unde…

This study involves over 12,000 Chinese patients with coronary heart disease who take blood thinners. The goal is to find new biological markers that can better predict who is at risk for dangerous blood clots or major bleeding. Researchers will combine genetic, protein, and imag…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study looks at factors that help blood clots in the main liver vein dissolve in people with liver scarring (cirrhosis) and enlarged stomach veins. Researchers will follow 1,500 patients over time to see what influences clot recovery. The goal is to help doctors and patients …

This study is testing whether an artificial intelligence system can predict serious complications in people hospitalized with a pulmonary embolism (a blood clot in the lungs). Researchers will analyze CT scans from 2,000 adults to see if the AI can identify who is likely to die o…

This study looks at whether information from CT scans, along with lab tests, can predict which patients with a blood clot in the lungs (pulmonary embolism) will have serious problems within 30 days. Researchers will collect data from 300 patients to build a prediction tool. The g…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study will review the medical records of 10 patients who developed acute pancreatitis within two weeks after a procedure to remove blood clots (percutaneous mechanical thrombectomy). The goal is to find out how often this complication happens, what patient or procedure facto…

This pilot study aims to see if certain blood markers that indicate clotting increase when atrial fibrillation (AFib) is more active. Researchers will take blood samples from 20 adults before, during, and up to 90 days after a catheter ablation procedure. The goal is to better un…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study will collect leftover blood samples from 10 newborns with severe heart defects who have surgery at Boston Children's Hospital. Researchers want to understand why these babies are more likely to develop dangerous blood clots after surgery. They will look at tiny molecul…

This study looks at how four types of central venous catheters (thin tubes placed in large veins) affect the body's clotting system. Researchers will take blood samples from 88 adults right after catheter insertion and again after flushing, to measure clotting changes. The goal i…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. It aims to understand bleeding risks during pregnancy and childbirth for mothers, and how children develop antibodies to factor VIII treatment. By observing families over time, researchers …

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study is looking for better ways to predict blood clots in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will measure specific markers in the blood of 300 participants to see if they can tell who is at higher risk for clots. The goal …

This study is collecting long-term safety and effectiveness data on treatments for various blood disorders, including hemophilia, sickle cell disease, and clotting disorders. It aims to enroll 3000 people of any age with these conditions. Researchers will monitor side effects, co…

This observational study will follow 1,000 patients in Poland who undergo a procedure to open completely blocked heart arteries. Researchers will collect data on success rates, complications, and long-term outcomes to understand what works best in everyday practice. The goal is t…

This study looks at leftover blood samples from 100 patients having heart surgery to see how certain immune cells (monocytes) change during the procedure. The goal is to understand links between inflammation and blood clotting risks. No new treatments are being tested; it is pure…

This study compares two methods for opening completely blocked heart arteries: antegrade dissection and re-entry (ADR) versus a retrograde approach. Researchers will measure procedure time, success rates, complications, and even doctor stress levels. 74 participants with difficul…

This study looks at whether common blood thinners like heparin can mess up lab tests for another blood thinner, argatroban. Doctors often switch patients from heparin to argatroban, but current tests can't tell the two drugs apart. Researchers will analyze blood samples from 70 a…

This study is a registry that gathers medical information from up to 40,000 people who have had surgery for stroke, brain aneurysm, or other brain blood vessel problems. Researchers will look at this data to find patterns that help predict recovery and compare different treatment…

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study looks at how blood clotting changes in pregnant women and whether these changes can predict complications like blood clots or high blood pressure. Researchers will study 100 women aged 18-40 with natural pregnancies. The goal is to use machine learning to find hidden r…

This study looks at how the common sweetener erythritol affects blood clotting and blood vessel health compared to aspartame. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with each sweetener for two weeks. Researchers will measure markers of platel…

This study looks at how different ovarian stimulation protocols affect blood clotting in 300 infertile women, including those with endometriosis. Researchers will measure clot formation and breakdown before and after treatment. The goal is to understand which protocols may be saf…

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

This study looks at how thick the blood is in 160 people with polycythemia (a condition with too many red blood cells). Researchers want to see if thicker blood causes more symptoms like headaches or dizziness, and how it differs between types of polycythemia. No new treatments a…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study looks at how blood cells interact and what goes wrong in inherited bleeding disorders like Glanzmann thrombasthenia. Researchers will analyze blood samples from up to 60 healthy volunteers and patients to find genetic defects. The goal is to better understand these con…

This study looks at why cancer patients have a much higher risk of developing blood clots. Researchers will collect blood clots from 120 patients (with and without cancer) who undergo a procedure to remove clots. They will analyze the clots for cancer cells and other factors to b…

This observational study follows 700 adult liver transplant recipients to understand how portal vein thrombosis (a blood clot in the liver's main vein) impacts their recovery and long-term health. Researchers will compare those with and without the clot to identify risk factors a…

This study looks at whether giving low-risk blood clot patients a 4G tablet for remote check-ups, education, and questionnaires is practical and satisfying for patients and doctors. Fifty participants will use the tablet for up to a year while following standard treatment. The go…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is tracking 400 people with acute or subacute blood clots in their legs to see how well endovascular treatments (minimally invasive procedures using catheters, balloons, stents, or clot-removal devices) work. The main goal is to see how many patients avoid amputation a…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…