Could less be more? new trial aims to protect preemie brains from bleeding

NCT ID NCT06676904

Recruiting now Disease control Sponsor: NICHD Neonatal Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving platelet transfusions only when levels are very low can help extremely premature babies (born at 23-26 weeks) survive without major bleeding. About 2,400 infants will be randomly assigned to a lower or higher transfusion trigger. The goal is to find the safest balance to prevent harm while avoiding unnecessary transfusions.

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Conditions

The condition(s) this trial relates to.

fetal growth restriction Infant, Newborn, Diseases perinatal disease thrombocytopenia thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFANT, EXTREMELY LOW BIRTH WEIGHT INFANT, NEWBORN, DISEASES INFANT, SMALL FOR GESTATIONAL AGE NEONATAL PLATELET TRANSFUSION THROMBOCYTOPENIA THROMBOSIS

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Case Western Reserve University, Rainbow Babies and Children's Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
Cincinnati Children's Medical Center
RECRUITING

Cincinnati, Ohio, 45267, United States
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30303, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Northwestern Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Pediatrix Medical Group
RECRUITING

San Antonio, Texas, 78229, United States
Sharp Mary Birch Hospital for Women & Newborns
RECRUITING

San Diego, California, 92123, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87131, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center at Dallas
RECRUITING

Dallas, Texas, 75235, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States

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