Can a sedative help rebuilt tissue survive after cancer surgery?

NCT ID NCT06993740

Completed Disease control Sponsor: Dharmais National Cancer Center Hospital Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine versus a placebo, and will also measure blood markers related to inflammation, blood clotting, and tissue repair. The goal is to see if this drug can reduce complications like flap failure by protecting blood vessels and improving blood flow.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexmedetomidine, a sedative given intravenously during and after surgery
What this could lead to: If effective, this could improve the success of reconstructive surgery in cancer patients, reducing the risk of flap failure and the need for additional operations.
What could go wrong: This is a small, early-stage trial, and the results may not apply to all patients. Dexmedetomidine can cause low blood pressure or slow heart rate, and its benefit over standard care is not yet proven.

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Conditions

The condition(s) this trial relates to.

cancer Inflammation inflammatory disease limb ischemia thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA FLAP FAILURE RISK FACTORS FLAP ISCHEMIA FLAP MONITORING FLAP NECROSIS GLYCOCALYX INFLAMMATION MICROSURGERY OXIDATIVE STRESS SURGERY THROMBOSIS

Contacts and locations

Locations

Dharmais National Cancer Center Hospital

Jakarta, DKI Jakarta, 11420, Indonesia

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