SURGERY

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive…

This trial investigates whether playing a virtual reality (VR) cognitive stimulation game can help older adults with mild memory problems stay mentally sharp and avoid delirium after major surgery. Participants, aged 65 and older, will use an Oculus Quest 2 headset for 20 minutes…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests if temporarily blocking the blood supply to the uterus and ovaries during minimally invasive fibroid surgery can reduce blood loss. About 120 women with large or numerous fibroids will be randomly assigned to receive the vessel-blocking technique or standard surg…

This study compares two surgical techniques for treating nasopharyngeal cancer that has come back after radiation. 500 participants will be randomly assigned to receive either low-temperature plasma ablation or high-frequency electrocautery. The goal is to see which method leads …

This trial compares two laser methods (MoLEP and ThuFLEP) for removing prostate tissue in men with enlarged prostates (over 80cc). 120 men aged 40-90 who need surgery will be randomly assigned to one of the two lasers. The main goal is to see which technique is faster, while also…

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) with advanced liver scarring disappear without making the scarring worse. It involves 100 obese adults with NASH and significant liver fibrosis. Partic…

This study tests whether a machine that keeps donated livers working outside the body can help doctors safely use livers that were previously considered too risky for transplant. About 186 adults on the liver transplant waiting list will be randomly assigned to either receive a s…

This trial compares four different surgical techniques for treating pilonidal sinus, a painful skin condition near the tailbone, in adolescents aged 12 to 18. The goal is to find which method causes the least pain, fewest complications, and lowest chance of the sinus coming back.…

This study is tracking 1,000 people who receive Terumo aortic stent grafts to repair aneurysms in the abdomen or chest. Researchers are monitoring how well the devices work and any complications, like death related to the aorta. It is an observational registry, meaning no new tre…

This study compares two treatments for bleeding after heart surgery: FEIBA (a special clotting medicine) and fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood transfusi…

This large phase 3 study is testing different combinations of chemotherapy, radiation, immunotherapy, and targeted drugs given before surgery for esophageal cancer. The goal is to find which approach works best to improve survival. The trial will enroll 2,000 adults with stage I …

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (an irregular heartbeat) during heart surgery. About 30 adults aged 18 to 85 who need heart surgery and have a history of atrial fibrillation will take part. The device aims to create sca…

This study tests a program called PROADAPT for women aged 70 and older with advanced ovarian cancer who need surgery. The program includes exercise, nutrition advice, education, and medication management before and after surgery. The goal is to see if it reduces serious complicat…

This study will track 16,000 children and adults who have robotic surgery to see how safe and effective it is, and how much it costs. Researchers want to know if the high-tech robots are worth the expense, especially for kids. The main focus is on complications during and after s…

This study tests a technique called systematic margin shaving during breast-conserving surgery for breast cancer. The idea is to remove a thin extra layer of tissue around the tumor right after the main lump is taken out, based on a pathologist's check. Researchers want to see if…

This trial tests a non-invasive wrist monitor that continuously checks for arm movement asymmetry, a sign of stroke. It aims to alert healthcare workers quickly, reducing delays in treatment. The study involves 1,200 high-risk surgery patients and focuses on device safety and acc…

This study is testing two new diagnostic kits that use blood samples or tumor tissue to predict if early-stage lung cancer will come back after surgery. Researchers will enroll 236 people with stage IA to IIIA lung cancer who have had their tumor fully removed. The goal is to see…

This study tests a wearable device called Neuralert that monitors patients for signs of stroke. It is designed to alert nurses faster than current methods. The trial involves 50 adults who are at high risk for stroke after heart or blood vessel surgery. Each person wears a device…

This study tests whether an educational video can increase women's interest in having their fallopian tubes removed during non-gynecologic surgery to prevent ovarian cancer. Participants watch a video and complete questionnaires before and after. The study involves 266 women aged…

This pilot study is testing whether a light-activated gel applied inside the nose before surgery can prevent infections afterward. Eighty adults having nasal surgery will either get the light treatment or a plain gel. Researchers will track who needs antibiotics for infection wit…

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after surgery. About 8,600 adults having high-risk operations (like cancer or joint surgery) will be randoml…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury, a common complication. 242 adults scheduled for elective heart surgery will receive either the supplements or a placebo. The goal is to see if these mitochondrial…

This study tests whether remimazolam besylate works as well as dexmedetomidine for keeping patients lightly sedated while on a breathing machine after non-cardiac surgery. About 306 adults aged 18–64 will take part across five hospitals in China. The goal is to see if remimazolam…

This study tests two different methods of patient-controlled pain pumps to see which one reduces opioid use and improves pain relief after surgery. About 1170 adults having various surgeries will be randomly assigned to one of two pump settings. The goal is to find a smarter way …

This study tests whether giving patients a personalized prediction tool and extra support for mental health and physical function can improve satisfaction one year after knee replacement surgery. About 300 adults at higher risk of dissatisfaction will be randomly assigned to eith…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study tests whether giving tranexamic acid (TXA) before rhinoplasty (nose job) can lessen bleeding during surgery and reduce bruising and swelling afterward. Sixty adults having cosmetic or functional nose surgery will be randomly assigned to receive TXA or a placebo. Resear…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests whether listening to your own choice of music during awake hand surgery lowers anxiety more than standardized relaxation music. 170 adults having hand surgery with only local anesthetic will be randomly assigned to one of the two music groups. Researchers will me…

This study compares two common surgeries for an enlarged prostate (BPH): a newer laser technique (MoLEP) and a standard electrical procedure (Bi-TURP). About 130 men with moderate to severe symptoms will be randomly assigned to one surgery. The main goal is to see which approach …

This study compares two common ways to manage pain after surgery: NSAIDs (like ibuprofen) plus acetaminophen, or low-dose opioids (like oxycodone) plus acetaminophen. About 900 adults having gallbladder removal, hernia repair, or breast lump removal will be randomly assigned to o…

This study tests whether combining a therapeutic clown with progressive relaxation exercises can reduce fear, anxiety, and stress in children aged 6-10 before circumcision surgery. 162 children will be split into three groups: one does relaxation exercises with a clown, one with …

This study tests whether giving dexmedetomidine and esketamine during and after surgery can help patients recover better. 316 adults having general anesthesia will receive one or both drugs, and their recovery quality will be measured using a 15-item questionnaire. The goal is to…

This study looks at two different methods for using a patient-controlled pain pump after surgery. The goal is to see if a new, time-based method can reduce the amount of opioids needed while still controlling pain effectively. About 450 adults having various surgeries will take p…

This study tests a wellness program designed for Black patients aged 60 and older who are scheduled for surgery and have symptoms of depression or anxiety. The program includes up to 10 remote sessions before and after surgery, with optional faith-based counseling and family invo…

This study tests which nerve block technique better controls pain after open-heart surgery. 66 adults will receive one of two ultrasound-guided injections before surgery. The goal is to reduce the need for strong painkillers (opioids) and improve comfort during recovery.

This study looks at whether eating solid food before a WALANT procedure (a type of hand surgery using only local anesthesia) can reduce anxiety and nausea compared to fasting. Researchers will randomly assign 134 participants to either eat or fast before their surgery and then co…

This study compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection around the nerve versus a small-incision surgery to relieve pressure. Researchers will measure pain and hand function in 60 adults with mild to severe symptoms over 12 weeks. The goal is…

This study compares two common ways to manage pain in children after they leave the hospital following surgery. About 900 kids having their tonsils, gallbladder, or knee scoped will be randomly assigned to receive either NSAIDs plus acetaminophen or low-dose opioids plus NSAIDs a…

This study tests whether using virtual reality can help patients feel calm before heart surgery, reducing their need for anxiety medication. About 40 adults who request medication for pre-surgery anxiety will try VR instead. The goal is to see if VR can provide comfort without th…

This study tests whether bright green light can help reduce pain and the need for painkillers after surgery. Sixty adults having laparoscopic or robotic surgery will be randomly assigned to receive either bright green light or normal dim light in their hospital room. Researchers …

This study tests whether using a walking platform every day after cancer surgery helps patients aged 65 and older regain their normal walking speed by the time they leave the hospital. Sixty participants will do short walking sessions starting the day after surgery. The goal is t…

This study tests whether a special geriatric care program before and after colorectal cancer surgery helps patients aged 70 and older recover their daily functioning better than standard care. The program includes early nutrition support, early mobilization, and careful managemen…

This study tests whether coloring mandalas for 20 minutes before elective surgery can lower patients' anxiety and stress. Sixty adults scheduled for gallbladder surgery will be randomly assigned to either color a mandala or receive standard care. Researchers will measure anxiety …

This study looks at whether listening to ney music, a traditional Turkish wind instrument, can help people who have had lumbar disc surgery feel less pain and anxiety, sleep better, and have a better quality of life. About 60 adults will be split into two groups: one group will l…

This study compares a home pelvic floor physical therapy program to standard care for 30 women having endometriosis surgery (without hysterectomy). Participants will report their pain and quality of life over the recovery period. The goal is to see if a simple home program can ea…

This study tests a surgical technique called targeted muscle reinnervation (TMR) to prevent phantom limb pain and stump pain after a leg amputation. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to receive either TMR or standard ne…

This study tests whether spraying a cooling mist (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. Eighty adults will have half their surgical site pre-cooled and the other half not, then rate their pain. The goal is to f…

This study tests whether giving a single dose of the steroid dexamethasone just before minimally invasive spine fusion surgery can lower back pain afterward and reduce the need for strong painkillers like morphine. Sixty adults aged 50–80 having one- or two-level spine fusion wil…

This study tests a device called FreeO2 that automatically adjusts oxygen levels during noninvasive breathing support. It includes 10 patients with COPD flare-ups or after weight-loss surgery. The goal is to see if the device keeps oxygen in a safe range better than manual adjust…

This study tests whether using nerve monitoring tools during breast cancer lymph node removal can help surgeons identify and protect nerves that often cause long-term pain. Six women with breast cancer will have the procedure, and researchers will check if the nerve signals can b…

This study tests a program called VISACT that uses visual aids, provider coaching, and organizational training to help surgery patients with low health literacy. The goal is to improve recovery and reduce complications. The study will enroll 1050 patients and providers at the Uni…

This study investigates why some men have difficulty using the pump of their inflatable penile prosthesis after surgery, leading to dissatisfaction. Researchers will look at factors like age, weight, pump type, and whether patients saw a demonstration before surgery. The goal is …

This study will compare pain levels after three different surgical methods for removing lymph nodes in the neck (lateral neck dissection) in people with thyroid cancer. The three methods are robotic surgery, endoscopic surgery, and traditional open surgery. Researchers will measu…

This study tests whether a wearable device called MultiSense® can safely monitor elderly patients (65+) at home after major surgery. The goal is to see if it reduces hospital stays and emergency visits. 80 participants will use the device, and researchers will track recovery qual…

This study looks at how much fluid patients should receive during robotic prostate surgery. It compares a standard approach with a more restricted one, using a non-invasive heart monitor to guide decisions. The goal is to see which method keeps tissues better perfused, measured b…

This study observes 10,000 adults undergoing general anesthesia for surgery to see how breathing machines are used and whether they are linked to lung complications. Researchers will track ventilator settings, patient details, and any lung problems or side effects that occur. The…

This study will follow 50,000 adults having planned non-cardiac surgery at two hospitals in Sweden. Researchers want to see if how much physical activity people report doing before surgery can help predict complications like infections, heart problems, or death. The goal is to fi…

This pilot study is testing whether letting people eat their regular diet right after colon surgery is safe and can improve their quality of life. Ten adults scheduled for colon removal will be followed for 30 days. The goal is to see if simplifying diet advice is feasible and do…

This study creates miniature, lab-grown versions of liver cancer tumors from patient biopsies. Researchers will test how well different treatments work on these models and look at how gut health and the tumor's environment affect the disease. The goal is to better understand live…

This study tests whether patients can wear a virtual reality (VR) headset during awake brain surgery to help them stay calm and complete thinking and language tests. First, the VR headset was tested on people having orthopedic surgery under local anesthesia to make sure it is saf…

This study tests a new 3D technology that combines standard scans (like CT or MRI) with real-time images to help surgeons guide head and neck surgery more precisely. About 27 adults scheduled for head and neck surgery will have a 3D scan created using a smartphone app during a st…

This study is tracking 10,000 orthopedic surgery patients using a smartphone app to measure pain, activity, and opioid use before and after surgery. The goal is to identify which patients are at high risk for long-term opioid use and to create a tool that helps doctors prescribe …

This study tests different ways to stimulate the brain during surgery to monitor motor function while minimizing patient movement. Researchers will use accelerometers and microscope video to measure movement. The goal is to make brain surgery safer by protecting areas that contro…

This study aims to create a decision aid for people with lung adenocarcinoma who need to decide whether to have molecular testing after surgery. Researchers will interview patients, family members, and doctors to understand what information is needed. The final tool will be teste…

This study tests whether giving doctors a patient's genetic information before surgery helps them choose safer medications. About 1,900 adults having planned surgery at the University of Chicago will provide a blood sample for genetic testing. Half the time, doctors will see the …

This large clinical trial is testing whether the type of anesthesia used during lung cancer surgery affects the chances of the cancer coming back. Over 5,000 people having surgery for early-stage non-small cell lung cancer will be randomly assigned to receive either intravenous p…

This study will look at up to 1.2 million patients to see how long they fast before surgery and whether longer fasting leads to problems like nausea, low blood pressure, or kidney injury. Researchers want to find out if current fasting guidelines are too strict and might actually…

This study looks at two types of surgery for pancreatic and liver tumors: open surgery and minimally invasive surgery. Researchers want to see which one leads to better survival, shorter hospital stays, fewer complications, and lower costs. The study will review records of 431 pa…

This study will follow 5,000 people who have surgery to repair a torn Achilles tendon. Researchers will track how many patients re-rupture the tendon, how well they recover, and how many return to sports. The goal is to learn which surgical techniques work best over the long term…

This study tests a new process to help older adults (age 80+) get a comprehensive geriatric assessment (CGA) before major surgery. The goal is to see if a special implementation package can increase the number of patients referred and assessed. Researchers will compare results to…

This study is testing the best depth to insert an esophageal stethoscope (a tube with a temperature sensor) to accurately measure core body temperature during surgery. Researchers will compare readings at different depths against a standard ear thermometer in 40 adults undergoing…

This study compares two methods for getting rid of leftover opioid painkillers after surgery: a special pouch that deactivates the drugs, and a prepaid envelope to mail them back. Researchers will track which method more people actually use. The goal is to find a simple, effectiv…

This study tests a computer system that helps doctors decide which patients need blood prepared before surgery. About 1 million patients in the US need blood transfusions during surgery each year, but often too much blood is prepared, leading to waste. The system uses patient dat…

This study tests whether giving extra arginine (a nutrient) to preterm and full-term infants after major bowel surgery or a serious gut infection (necrotising enterocolitis) can improve their immune function. Researchers will measure changes in gene activity related to infection-…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to a few spots. The goal is to see how well treatments like radiation or surgery work, alone or with chemotherapy. Researchers want to find out which patients benefit most fro…

This study is testing whether wearable sensors on the chest and fingers can detect early signs of patient decline after major surgery. Over 1,300 adults in eight countries will wear the sensors before, during, and after their operation for up to 10 days. The data will be used to …

This study looks at whether removing only a few key lymph nodes (sentinel node biopsy) is better than removing no nodes at all in women with early-stage endometrial cancer. The goal is to see if this approach helps women return to normal activities faster and does not increase th…

This study tests a quality improvement program called '5 Rs to Rescue' to help hospitals in Africa better identify and treat complications after surgery, which can prevent deaths. The program includes regular checks, early warning systems, and team reviews. About 6000 adults havi…

This study is testing whether women with early-stage luminal breast cancer can follow a special diet (ketogenic or protein-restricted) for about 9 days before their surgery. The main goal is to see if patients can stick to the diet. Researchers will also look at how the diet affe…

This study is looking at 100 intensive care patients to see if certain inflammatory markers in urine, blood, and sputum can help predict acute kidney injury. The researchers are comparing patients with sepsis, those recovering from major surgery, and non-inflamed individuals. The…

This study is testing whether continuously monitoring oxygen levels while patients are moved from the operating room to the recovery room can reduce the number of times oxygen drops too low. Researchers will compare oxygen readings taken at the start and end of transport, and the…

This study tests whether pressing on the left side of the neck during mask ventilation can prevent air from entering the stomach in children aged 2 to 10. The maneuver is done with two fingers applying gentle pressure to compress the esophagus. Researchers will use ultrasound to …

This study will use daily bedside ultrasound to look for blood clots caused by central venous catheters in 100 adults after major surgery. Half the patients had cancer surgery, half had non-cancer surgery. The goal is to learn how often clots form and what factors increase the ri…

This study looks at 300,000 surgical patients in Stockholm to see how the COVID-19 pandemic impacted their recovery. Researchers will track deaths, complications, and how long people stayed in the hospital. The goal is to understand the pandemic's effects on surgical care, not to…

This study tests whether using a device to continuously monitor heart rate, oxygen, and blood pressure after surgery — both in the hospital and at home — helps patients spend more days at home in the first month. About 110 adults having major abdominal or vascular surgery will be…

This study tests whether starting gentle exercises with a special brace 3 weeks after peroneal tendon surgery leads to less pain and better function than the standard 6 weeks in a cast. Fifty adults in Sweden who have surgery for a torn peroneal tendon will be randomly assigned t…

This observational registry is following 500 patients aged 18–80 who undergo robotic-assisted laparoscopic surgery using the Senhance Surgical System. The goal is to track any adverse events and gather real-world safety data across urology, abdominal, thoracic, and gynecologic pr…

This study looks at how modern, minimally invasive lung cancer surgery affects the heart's electrical signals. Researchers will monitor 100 adults before, during, and after surgery to see if temporary changes occur. The goal is to better understand the heart stress caused by the …

This study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …