SURGERY

This study is testing whether giving two medicines, tranexamic acid (TXA) and desmopressin, before surgery can reduce bleeding in people with kidney problems. The trial will include 100 adults with chronic kidney disease or acute kidney injury who are having non-cardiac surgery. …

This study tests whether a special machine that keeps donated livers working outside the body can safely increase the number of usable livers for transplant. About 186 adults on the liver transplant waiting list will be randomly assigned to either receive a liver that passed the …

This study is a global registry that will follow about 1000 people who receive a Terumo aortic graft to treat an aneurysm in the chest or belly. The goal is to see how safe and effective the grafts are in everyday medical practice. Researchers will track deaths related to the aor…

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale de…

This study compares two types of keyhole surgery to remove the left side of the pancreas in people with non-cancerous growths. About 256 adults will be randomly assigned to either robot-assisted or standard laparoscopic surgery. The goal is to see which method leads to fewer comp…

This study tests a technique called systematic shaving during breast-conserving surgery. The goal is to see if removing a thin layer of extra tissue around the tumor reduces the chance that cancer cells are left behind, which often requires a second operation. About 234 women wit…

This study compares two surgical techniques for people whose nasopharyngeal cancer has come back after initial treatment. Half the participants will receive a newer, low-temperature plasma ablation, while the other half will receive standard high-frequency electrocautery. The goa…

This study tests whether temporarily clamping the blood vessels that supply the uterus and ovaries during minimally invasive fibroid surgery can reduce blood loss. About 120 women with large or numerous fibroids will take part. The goal is to make the surgery safer by lowering th…

This study tests if weight-loss surgery is better than standard medical treatment for reversing non-alcoholic steatohepatitis (NASH) with advanced liver scarring in obese adults. About 100 participants with a BMI of 30-50 and advanced fibrosis will be randomly assigned to surgery…

This study tests a special program called PROADAPT for women aged 70 and older (or 60+ with health issues) who have advanced ovarian cancer and need surgery. The program includes nutrition advice, physical exercises, and education before surgery, plus extra support during the hos…

This study compares two treatments for bleeding after heart surgery: FEIBA (a drug that helps blood clot) versus fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood trans…

This study aims to find the best treatment before surgery for esophageal cancer. It compares chemotherapy, chemoradiation, targeted therapy, and immunotherapy in 2000 adults with stage I-IVa disease. The goal is to improve survival and reduce side effects.

This early study tests a new device that uses short electrical pulses to treat atrial fibrillation (an irregular heartbeat) during heart surgery. About 30 adults aged 18-85 with a history of atrial fibrillation will receive the treatment. The goal is to see if the device safely c…

This study compares four different surgical methods for treating pilonidal sinus, a painful skin condition at the tailbone. Researchers will enroll 80 teens aged 12-17 to see which surgery leads to fewer complications and less pain. The goal is to find the most effective treatmen…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury, a common complication. About 242 adults scheduled for elective heart surgery will receive either the supplements or a placebo. The goal is to see if these mitocho…

This study checks if pressing on the side of the neck can stop air from entering the stomach when children are given oxygen through a mask during anesthesia. It involves 72 children aged 2 to 10 having planned surgery. Researchers will use ultrasound to see if the maneuver works …

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after high-risk surgeries like cancer or joint replacement. About 8,600 adults having elective surgery will …

This study tests whether watching an educational video can encourage women to choose a preventive surgery called opportunistic salpingectomy (removal of fallopian tubes) to lower their risk of ovarian cancer. About 266 women aged 45 and older who are already scheduled for non-gyn…

This pilot study is testing whether it is safe and helpful for people to eat a regular diet right after colon removal surgery. The researchers will follow 10 participants for 30 days to see if this approach reduces hospital readmissions and improves quality of life. The goal is t…

This study tests whether using virtual reality (VR) can help patients feel calm before heart surgery, reducing their need for anxiety medication. About 40 adults who request medication for pre-surgery nerves will try VR instead. The goal is to see if VR can provide comfort while …

This study compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection around the nerve versus a small-incision surgery to release the nerve. Researchers will measure pain and symptom changes over 12 weeks in 60 adults with mild to severe carpal tunnel. The…

This study looks at whether doing progressive relaxation exercises with a therapeutic clown can help children feel less scared and anxious before surgery. The study involves 162 children aged 6 to 10 who are having circumcision. They will be split into three groups: one doing rel…

This study tests whether using a walking platform every day helps people aged 65 and older regain their normal walking speed after cancer surgery. Researchers will compare how many patients recover their pre-surgery walking ability by the time they leave the hospital. The goal is…

This study tests whether listening to ney music (a traditional Turkish wind instrument) can reduce pain, anxiety, and improve sleep and quality of life in people recovering from lumbar disc surgery. Sixty adults will be randomly assigned to either listen to 15 minutes of ney musi…

This study looks at whether a less invasive procedure called sentinel node biopsy can help women with early-stage endometrial cancer recover faster and avoid side effects like leg swelling, compared to not removing any lymph nodes. About 760 women will be randomly assigned to one…

This study tests whether bright green light can help reduce pain and the need for painkillers after surgery. About 60 adults having laparoscopic or robotic surgery will be randomly assigned to receive either bright green light or regular dim light in their hospital room. Research…

This study tests a new way to give pain medicine after surgery. It compares a standard pump that gives a steady dose of opioids to a smart pump that adjusts the dose based on the patient's pain level. The goal is to see if the smart pump can lower the total amount of opioids need…

This study looks at whether tranexamic acid (TXA), a drug that helps blood clot, can reduce bleeding, bruising, and swelling in people having nose surgery (rhinoplasty). About 60 adults will take part. Researchers will measure blood loss during surgery and how much bruising and s…

This study looks at whether listening to your own choice of music can lower anxiety during hand surgery that uses only local anesthesia (you are awake). About 170 adults will be randomly assigned to hear either their preferred music or a standard relaxation track while in the ope…

This study is testing whether a short sleep-improvement program before knee or hip replacement surgery can help reduce pain and speed up recovery afterward. One hundred adults with insomnia who are scheduled for joint replacement will receive either sleep therapy or sleep educati…

This study compares two common pain relief plans for children after surgery: one uses anti-inflammatory drugs plus acetaminophen, and the other adds low-dose opioids. Researchers want to see which option controls pain better and causes fewer side effects. About 900 children havin…

This study looks at two different recovery plans after surgery for peroneal tendon injuries. About 50 adults in Gothenburg, Sweden, will be randomly assigned to one of the plans. Researchers will measure pain, movement, and calf strength before and after surgery for up to two yea…

This study tests whether giving a steroid called dexamethasone before minimally invasive spine fusion surgery can reduce back pain after the operation. Researchers will compare pain scores and morphine use in 60 adults aged 50-80 who are having surgery for spinal stenosis or disc…

This study looks at two different methods of giving pain medicine through a patient-controlled pump after surgery. The goal is to see if a new, time-based method can lower the amount of opioids needed, improve pain relief, and reduce side effects. About 450 adults having various …

This study looks at whether a dedicated geriatric peri-operative care team can help adults aged 70 and older recover daily function better than standard care after colorectal cancer surgery. About 90 participants will be randomly assigned to either the specialized team or usual c…

This study looks at whether eating solid food before a hand surgery (called WALANT) helps patients feel less anxious and nauseous. About 134 people will be randomly told to either eat or fast before their procedure. Researchers will compare anxiety, nausea, and satisfaction betwe…

This study compares two common surgeries for an enlarged prostate: a newer laser technique (MoLEP) and the standard bipolar TURP. The main goal is to see which approach leads to a shorter hospital stay. About 130 men with moderate to severe symptoms will be randomly assigned to o…

This study compares a home pelvic floor physical therapy program to standard post-surgery care for 30 women having endometriosis excision (without hysterectomy). The goal is to see if the home program improves pelvic pain, bladder/bowel symptoms, and overall quality of life durin…

This study tests a surgical technique called targeted muscle reinnervation (TMR) to prevent phantom limb pain and stump pain after a leg amputation. About 200 adults aged 18-75 who need a leg amputation due to vascular disease will be randomly assigned to receive either TMR or st…

This study tests two different numbing injections (nerve blocks) to see which one controls pain better after open-heart surgery. About 66 adults having heart surgery will receive one of the two blocks. The goal is to reduce the need for strong painkillers (opioids) and improve re…

This study tests whether giving dexmedetomidine and esketamine during and after surgery helps patients feel better and recover faster. About 316 adults having surgery under general anesthesia will take part. The goal is to see if these drugs improve pain, comfort, and emotional w…

This study compares two laser techniques—Moses 2.0 and Thulium Fiber—for removing prostate tissue in men with medium to large prostates (over 80cc). About 120 men aged 40-90 who need surgery for urinary symptoms will be randomly assigned to one method. The goal is to see which la…

This study tests whether spraying a cooling liquid (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. About 80 adults will have half their surgical site pre-cooled and the other half not, then rate the pain of each injecti…

This small study tests a device called FreeO2 that automatically adjusts oxygen levels during breathing support. It includes 10 patients with COPD flare-ups or after weight-loss surgery. The goal is to see if the device keeps oxygen in a safe range better than manual adjustments.

This study looks at whether a drug called remazolam besylate is as good as or better than another sedative (dexmedetomidine) for keeping critically ill patients calm and comfortable while they are on a breathing machine after non-cardiac surgery. About 306 adults aged 18-64 who n…

This study looks at whether coloring a mandala for 20 minutes before surgery can lower anxiety and stress. About 60 adults having gallbladder surgery will either color or receive standard care. Researchers will measure anxiety, stress, and vital signs like blood pressure and hear…

This study compares two common pain medicine combinations after surgery: NSAIDs (like ibuprofen) plus acetaminophen (Tylenol) versus low-dose opioids plus acetaminophen. About 900 adults having gallbladder removal, hernia repair, or breast lump removal will take part. The goal is…

This study looks at whether continuously monitoring oxygen levels while moving patients from the operating room to the recovery area can reduce the number of times oxygen drops too low. About 30 adults having surgery will take part. The goal is to see if this extra monitoring hel…

This study compares two types of anesthesia—inhaled gas versus intravenous propofol—during surgery for early-stage non-small cell lung cancer. The goal is to see if one method leads to fewer cancer recurrences or deaths. Over 5,000 adults undergoing curative lung removal will be …

This study examines the effects of fasting before surgery on patient outcomes, such as nausea, low blood pressure, and kidney injury. Researchers will analyze data from 1.2 million patients to see if longer fasting times are linked to more complications. The goal is to improve fa…

This study is testing whether wearable sensors that track heart rate, breathing, and temperature can help doctors spot early signs of trouble after surgery. About 1,332 adults having major surgery in eight countries will wear the sensors for up to 10 days. The sensor data is only…

This study looks at whether using extra devices to check vital signs (like heart rate and blood pressure) in the hospital and at home can improve recovery for adults after major abdominal or vascular surgery. About 110 participants will either get standard care or enhanced monito…

This study looks at two types of surgery for pancreatic and liver tumors: open surgery and minimally invasive surgery. Researchers want to see which one leads to better survival, shorter hospital stays, fewer complications, and lower costs. The study will review records of 431 ad…

This study tests whether a wellness program is practical and helpful for older Black patients who are about to have surgery and feel depressed or anxious. Researchers will enroll 50 people aged 60 and older to see how many join and complete the program. The goal is to learn if th…

This study tests a computer system that helps doctors decide which surgery patients need blood prepared before their operation. The goal is to make sure blood is ready for those who truly need it, while avoiding unnecessary preparation that wastes blood and money. About 50 patien…

This study tests whether a new process can help more older adults get a special health check-up before major surgery. The check-up, called a geriatric assessment, looks at overall health and helps plan care. Researchers will compare results to past data to see if the new process …

This study is looking at how well robotic surgery works and how safe it is for both children and adults. Researchers will track 16,000 people who need robotic surgery to see how they do during and after the operation. The goal is to understand the real benefits, risks, and costs …

This study looks at whether women with early-stage breast cancer can stick to a special diet—either a low-carb (ketogenic) or low-protein diet—for about 9 days before their surgery. The goal is not to treat the cancer directly, but to see if the diet is feasible and to study how …

This study is a registry that collects information on patients who have robotic-assisted laparoscopic surgery using the Senhance Surgical System. The goal is to track any side effects or complications. About 500 adults aged 18 to 80 who are expected to live at least 12 months can…

This study tests a non-invasive wrist monitor that continuously checks for stroke by detecting arm weakness. It aims to catch strokes faster in 1,200 high-risk hospital patients, while keeping false alarms low. The goal is to improve treatment and outcomes without any drugs or su…

This study aims to create a decision aid for people with a type of lung cancer (lung adenocarcinoma) who have just had surgery. The tool will help patients and their doctors work together to decide whether to do molecular testing on the tumor. About 190 people, including patients…

This study will follow 5000 people who have surgery to repair a torn Achilles tendon. Researchers want to see how often the tendon tears again, how well people return to sports, and what complications occur. The goal is to learn which surgical techniques work best over the long t…

This study creates tiny, lab-grown copies of liver tumors from 150 patients to better understand liver cancer and test how well different treatments might work. Participants will have their tumor samples collected during surgery, but no new treatment is given. The goal is to lear…

This study investigates why many ICU patients develop acute kidney injury, especially after sepsis or major surgery. Researchers will measure inflammatory markers in urine, blood, and sputum from 100 participants to see if these markers are linked to kidney damage. The goal is to…

This study looks at how modern, minimally invasive lung cancer surgery affects the heart's electrical signals and stress levels. Researchers will monitor 100 adult patients before, during, and after surgery to see if any heart changes occur and if they are temporary. The goal is …

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to only a few places. The goal is to see how well different treatments like radiation, surgery, or chemotherapy work. By understanding what helps these patients live longer, d…

This study tests a wearable device called Neuralert that monitors hospital patients at high risk for stroke. The device is worn on both arms and sends alerts if it detects signs of a stroke. The goal is to see if it can identify strokes faster than current methods. About 50 adult…

This study tests a quality improvement program called '5 Rs to Rescue' to reduce preventable deaths after surgery in African hospitals. The program focuses on better risk assessment, monitoring, and response to complications. 6000 adults in 20 hospitals across Ethiopia, South Afr…

This study looks at whether giving extra arginine (a nutrient) to infants after major bowel surgery or a serious gut infection (NEC) can improve their immune function. Researchers will compare three groups: some get arginine in their IV nutrition, some get it by mouth, and some g…

This study looks at whether giving doctors a patient's genetic information before surgery can help them choose safer medicines. About 1900 adults having planned surgery at the University of Chicago will give a blood sample to test for genes that affect how they respond to common …

This study tests a new 3D technology that combines standard medical scans (like CT or MRI) with a 3D image of the patient's head and neck to help surgeons during surgery. About 27 adults scheduled for head and neck surgery at Memorial Sloan Kettering will participate. Researchers…

This study looks at two ways to get rid of leftover opioid pain pills after surgery: mailing them in or using a special in-home disposal method. About 100 people who have not taken opioids before will be assigned one of these methods. The goal is to see which approach works bette…

This study is developing and testing two new kits that help predict if early-stage lung cancer will come back after surgery. One kit uses a tissue sample, and the other uses a blood test. Researchers will follow 236 patients to see how accurate these tests are at identifying thos…

This study aims to find the best insertion depth for an esophageal stethoscope with a temperature sensor to accurately measure core body temperature during surgery. Researchers will compare temperatures at different depths in 40 adults undergoing elective surgery. The goal is to …

This study aims to improve how doctors monitor brain function during surgery. By using accelerometers and microscope video, researchers hope to reduce patient movement during electrical stimulation, making surgery safer. About 203 adults undergoing brain surgery will participate.

This study will use daily bedside ultrasound to check for blood clots caused by vascular catheters in 100 adults after major surgery. Researchers want to see if the risk differs between cancer and non-cancer patients and what factors increase the chance of clots. Participants mus…

This study looks at how the COVID-19 pandemic impacted people who had surgery in Stockholm, Sweden. Researchers will track up to 300,000 patients to see if death rates, complications, or hospital stays changed during the pandemic. The goal is to understand the pandemic's effects,…