Can a gas added to Heart-Lung machines shield Newborns' kidneys?
NCT ID NCT04216927
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests whether adding nitric oxide gas to the heart-lung machine during surgery can prevent acute kidney injury in newborns with congenital heart defects. Up to 60% of these babies experience kidney damage after surgery, which can lead to serious complications. The study will compare babies who receive nitric oxide during bypass with those who receive oxygen alone, monitoring for signs of kidney injury in the first 72 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nitric oxide gas administered during cardiopulmonary bypass
- What this could lead to
- If effective, this simple addition to bypass could prevent acute kidney injury in newborns after heart surgery, reducing complications and improving recovery.
- What could go wrong
- This is a small, early-phase trial, and the benefit is not yet proven. Nitric oxide may not reduce kidney injury, and there are always risks with any intervention in fragile neonates.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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