Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a simple switch in how acetaminophen is given prevent delirium after hip surgery?

NCT ID NCT05425355

Recruiting now Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial compares intravenous (IV) acetaminophen to oral acetaminophen for managing pain and preventing delirium in adults aged 60 and older after hip fracture surgery. Participants receive either IV acetaminophen plus a placebo pill, or IV placebo plus oral acetaminophen, every 6 hours for 48 hours. The study aims to see if a larger trial is feasible and whether the IV route offers any advantage over the standard oral pill.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
acetaminophen (paracetamol) given intravenously or orally
What this could lead to
If IV acetaminophen proves better, it could reduce pain and delirium after hip fracture surgery in older adults, improving recovery.
What could go wrong
This is a small feasibility trial with only 42 participants, so results may not be conclusive. IV acetaminophen is already widely used, so the benefit over oral may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HIP-FRACTURE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hip fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIP-FRACTURE SURGERY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Toronto Western Hospital (UHN)

    RECRUITING

    Toronto, Ontario, M5T 2S8, Canada

    Contact

    Contact

More trials for these conditions

Other studies related to the condition(s) this trial covers.