Hip fracture

This study compares two common surgeries for a certain type of hip fracture in adults aged 60 and older: hip replacement (arthroplasty) versus internal fixation (using screws or pins). The goal is to see which approach helps people survive, walk independently, and spend more time…

This study tests whether giving blood transfusions quickly when hemoglobin drops can prevent delirium (sudden confusion) in patients 75 and older after hip fracture surgery. About 198 participants will be randomly assigned to either early transfusion or standard care. Researchers…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study follows 120 people who need hip revision surgery (replacing a previous hip implant) to see how well the Prevision hip stem works. The stem comes in different versions, and surgeons choose the best one for each patient. The main goal is to measure how well patients can …

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study follows 300 people who receive the IlluminOss device to treat broken bones from injury or disease. Researchers will track how well the device works, how safely it performs, and how patients recover over time. The goal is to gather real-world data on bone healing and re…

This phase 2 trial tests whether a 4-week course of an essential amino acid supplement can help older adults (65+) rebuild muscle after a hip fracture. Sixty participants will be randomly assigned to receive either the supplement or standard care alone. Researchers will measure m…

This study looks at whether a special vibrating device placed on the chest can improve breathing in older patients with a hip fracture who also have respiratory failure. 60 participants will receive the therapy for 5 days, and doctors will check their blood oxygen levels and lung…

This study tests a new sliding compression locking plate for treating fresh femoral neck fractures (a type of hip fracture). The goal is to see if this plate is safer and works better than current methods. About 1,150 adults who need surgery for this fracture will take part. The …

This study follows 368 adults who need a partial hip replacement (hemiarthroplasty) due to fractures, arthritis, or bone death. Researchers will check how well Corin hip devices work and how safe they are over 10 years. The goal is to see if patients can move better and have fewe…

This study looks at whether giving two doses of tranexamic acid (a drug that helps blood clot) is better than one dose at reducing blood loss and the need for blood transfusions in older adults having hip fracture surgery. The trial includes 120 people aged 65 and older. Particip…

This study is testing a special 3D-printed cage called the TRUMATCH Graft Cage to help repair large bone defects in the arm or leg. Five adults with hard-to-heal breaks will receive the cage during surgery. Researchers will track healing, complications, and recovery time over thr…

This study is testing a new type of metal nail (RFN-advanced) to repair broken thigh bones. About 40 adults with a fracture in the lower part of the thigh bone or the shaft will receive this implant. Researchers will track how well the bone heals, pain levels, and any problems ov…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study is checking how well a special nail works for fixing thigh bone fractures. The nail has a coating designed to reduce infection. About 100 adults with thigh fractures will get this nail and be followed for a year to see if the bone heals properly and how well they can u…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study is testing a fracture liaison service (FLS) combined with medication management for people with osteoporosis in a rural area. The program provides education, monitoring, and follow-up to help patients take their medications as prescribed. Researchers will enroll 200 ad…

This study is testing a new hip replacement system called Emphasys Hip Solutions in 30 people with hip osteoarthritis. Researchers will use special X-ray imaging to see how well the implant stays in place over two years. The goal is to make sure the implant is stable and works we…

This study follows 100 adults who need surgery for a broken thigh bone or a bone cut (osteotomy). They will receive a special nail with an infection-fighting coating. The goal is to see how well the bone heals and if the nail is safe over 12 months. The nail is already on the mar…

This study is checking how well the Z1 Femoral Hip System works and how safe it is for people who need hip replacement surgery. About 150 adults with hip problems like arthritis or fractures will be followed for 2 years. The main goal is to see how many implants are still in plac…

This study looks at whether doing hip fracture surgery within 6 hours, instead of waiting longer, can reduce deaths in patients who also have a recent heart injury. About 1100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) will be rand…

This study looks at whether older adults who break a hip from a simple fall might have an undiagnosed spinal cord condition called cervical myelopathy. Researchers will check 75 patients with a physical exam and, if needed, an MRI before they leave the hospital. The goal is to fi…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests a simple, family-led protocol called 'Delirium Zero' to prevent delirium (sudden confusion) in older adults after hip fracture surgery. About 140 patients over 65 will be randomly assigned to either standard care or the Delirium Zero protocol, which includes an o…

This study tests whether using a positive expiratory pressure (PEP) device before and after hip fracture surgery can prevent hospital-acquired pneumonia. About 566 patients will either receive the PEP therapy plus standard care or standard care alone. The goal is to see if this s…

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve mobility recovery in elderly patients after hip fracture surgery. Researchers will compare the iron group to a placebo group in 210 participants across three Danish hospitals. The main g…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study looks at whether a new type of nerve block, called the Quadro-Iliac Plane (QIP) block, helps people recover better after hip replacement surgery. Researchers will compare it to other standard blocks by measuring pain, how quickly people get up and move, and overall rec…

This study tests whether using blood flow restriction cuffs during low-intensity stationary cycling can safely improve muscle strength and mobility in older adults recovering from a hip fracture. Sixty hospitalized patients over age 65 will be randomly assigned to either real or …

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study compares two types of nerve blocks—suprainguinal fascia iliaca block (SIFI) and quadro-iliac plane block (QIPB)—for pain relief after hip fracture surgery. Researchers will enroll 70 adults undergoing hip fracture repair and measure pain scores and opioid use. The goal…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study compares two types of nerve blocks—the PENG block and the Deep Iliacus Plane Block—for pain relief during spinal anesthesia positioning and after hip fracture surgery. 75 adults aged 30-85 will receive one of the blocks plus standard pain medication. The goal is to see…

This pilot study is testing whether a dual-screw nail (InterTAN) helps people recover better after a broken hip than a standard single-screw nail (TFNA). Thirty adults with unstable hip fractures will be randomly assigned to receive one of the two devices during surgery. The rese…

This study tests whether remimazolam, a newer anesthesia drug, causes less confusion (delirium) after surgery than the standard drug propofol in elderly patients having hip or knee replacement. Researchers will monitor 82 participants for three days after surgery to check for del…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study compares two approaches to pain control in elderly patients having hip fracture surgery: a standard femoral nerve block versus a femoral block plus an additional PENG block. The goal is to see if the combination reduces pain during spinal anesthesia positioning and low…

This study is testing whether adding a sensor-based device to standard physical therapy can improve both thinking and movement in frail older adults recovering from hip fracture surgery. Thirty participants aged 65-89 will use the device for part of their rehab. The goal is to se…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This study tests whether a long-acting form of the anesthetic bupivacaine, combined with regular bupivacaine, can control pain better than the standard drug ropivacaine after hip replacement. Sixty adults with hip fractures or necrosis will receive one of the two treatments via a…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This trial tests whether a computer navigation system called ADAPT helps surgeons place screws more accurately during hip fracture repair. About 96 adults aged 50-85 with certain hip fractures will be randomly assigned to receive surgery with or without the navigation system. The…

This study tests whether injecting the steroid dexamethasone around the hip joint during surgery can reduce pain, nausea, and hospital stay for people with a broken hip. About 110 adults aged 50-90 having hip replacement for a femoral neck fracture will take part. The goal is to …

This study tests whether a nutritional supplement (complex carbohydrates and essential amino acids) taken for three weeks after hip fracture surgery can reduce muscle loss in adults aged 65 and older. Participants are randomly assigned to receive either the supplement or standard…

This study compares two types of nerve blocks—sacral erector spinae plane block and pericapsular nerve group block—for pain relief after hip hemiarthroplasty. Eighty adults aged 50-90 with a hip fracture will receive one of the blocks before surgery. Researchers will measure pain…

This study tests a special nursing program based on Snyder Hope Theory for people aged 60 and older who recently had hip fracture surgery. The program includes counseling, goal setting, and rehab training to improve hope, reduce pain and anxiety, and help patients regain function…

This pilot study tests whether personalized audio-recorded messages, played three times daily for the first three days after hip fracture surgery, can help prevent delirium in patients aged 60 and older. The study will enroll 30 participants and focus on whether the intervention …

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover strength and mobility after a hip fracture. The vibration is applied to the leg muscles for 30 minutes, five times a week, for four weeks. The main goal is…

This study tests whether a 12-week course of a cetylated fatty acid supplement can improve bone healing after surgery for a broken femur or tibia. One hundred adults will receive either the supplement or a placebo, and healing will be tracked with X-rays and pain scores. The goal…

This study tests whether giving elderly patients a combination of esketamine and dexmedetomidine after hip fracture surgery can improve their sleep quality. 96 patients aged 65 and older will be randomly assigned to receive either the drug combo or a placebo (saline) for 48 hours…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study tests if freezing a specific nerve group (cryoablation of the PENG) provides better pain control 30 days after hip fracture surgery compared to the usual method (a fascia iliaca catheter). About 150 adults aged 18-85 having hip fracture repair will be enrolled. The mai…

This study compares standard pain management to a special nerve block called PENG in 70 adults having hip fracture surgery. The goal is to see if the block reduces pain, the need for extra painkillers, and helps patients get moving faster. Researchers will also check for side eff…

This study compares AI-assisted versus surgeon-planned screw placement in hip fracture surgery. About 334 adults with femoral neck fractures will be randomly assigned to one of two groups. The goal is to see if AI guidance leads to more accurate screw placement, shorter surgery t…

This study compares two ultrasound-guided nerve blocks—supra-inguinal fascia iliaca block and pericapsular nerve group block—to see which one better reduces pain when positioning patients for spinal anesthesia during femur fracture surgery. Seventy adults with a broken femur will…

This study tests two sedative drugs, remimazolam and midazolam, in adults aged 65 and older having orthopedic surgery with regional anesthesia. The goal is to see which drug provides better sedation during surgery and causes fewer problems with thinking and memory shortly after. …

This study tests a treatment called Remote Ischaemic Conditioning (RIC) for people recovering from hip fracture surgery. RIC involves inflating a blood pressure cuff on the arm or leg for short periods to trigger the body's own protective responses. The trial will include 12 adul…

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study follows about 100 adults who received a Tipmed hip replacement during routine care. Researchers track complications and hip function over two years to see how well the device performs in real life. The goal is to gather practical evidence on safety and effectiveness, n…

This study is testing whether giving elderly patients with a broken hip and high frailty a special nutritional drink before surgery can help them stay more stable during the operation and recover better. Researchers will compare patients who get the drink with those who follow st…

This study looks at two ways to treat pelvic fractures in people aged 60 and older: surgery or non-surgical care. Researchers will follow 120 patients to see if a larger trial comparing these treatments is possible. The goal is to understand patient and surgeon preferences and wh…

This study will use data from 1,200 hip fracture patients to build a machine learning model that predicts mobility and daily living independence three months after injury. The goal is to help patients and doctors set realistic expectations for recovery. No new treatments are bein…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks at whether a special mobility program, designed with input from patients and doctors, can help older adults move more after hip fracture surgery. About 25 participants will try the program during their hospital stay. Researchers will check if the program is pract…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study looks at whether surgery improves walking in older adults with pelvic ring fractures. Researchers will compare walking patterns and hospital outcomes between those who get surgery and those who don't. The goal is to see if surgery leads to better recovery and quality o…

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study aims to translate and culturally adapt the Groningen Frailty Indicator (GFI) questionnaire for Greek patients with hip fractures. Researchers will enroll 89 adults over 65 who are undergoing hip fracture surgery. The goal is to create a reliable Greek version of the GF…

This study looks at whether older adults who are frail before hip fracture surgery have higher levels of inflammation, measured by simple blood tests. Researchers will enroll 200 patients aged 65 and older and check their frailty using a standard questionnaire. The goal is to bet…

This study compares two recovery approaches after surgery for pelvic fractures: starting to put weight on the leg immediately versus waiting a while. Researchers will track 50 adults aged 18 to 55 to see which group has better function, less pain, and stronger muscles. The goal i…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study looks at whether measuring frailty—a person's overall physical weakness—can improve predictions of death within 90 days after hip fracture surgery. Researchers will follow about 200 older adults who have surgery for a broken hip. They will compare the standard risk sco…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study tests a simple conversation aid and brief training for doctors to improve discussions about anesthesia options with patients who need hip fracture surgery. About 1,881 adults aged 50 and older at six U.S. hospitals will take part. The goal is to see if this approach in…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study looks at different ways to surgically fix a broken hip in adults under 65. The main goal is to see if a new implant keeps the bone more stable during healing compared to standard screws. Researchers will use a special X-ray method to measure any movement in the fractur…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at whether a blood test marker called Monocyte Distribution Width (MDW) can help predict complications and survival in elderly patients with hip fracture. Researchers will follow 100 patients aged 65 and older, measuring MDW and other inflammatory markers at admi…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study looks at whether the Iowa Level of Assistance (ILoA) scale is a reliable tool for measuring functional recovery in patients after joint replacement surgery. Researchers will have multiple physiotherapists assess the same patients to see if their scores agree. The goal …

This study looks at oxygen levels in adults over 65 after hip fracture surgery, comparing regional (spinal) anesthesia to general anesthesia. Researchers will measure oxygen saturation and track complications like sleep apnea, delirium, and hospital stay length. The study is obse…

This study looks at 374 hip fracture patients who take blood thinners (DOACs). Doctors often delay surgery due to bleeding concerns, but waiting may cause other problems. The study compares early surgery (within 24 hours) to delayed surgery to see if early surgery increases the n…

This observational study at Shanghai Geriatric Medical Center looks at how the anesthetic drug ciprofol behaves in 50 older adults (65+) undergoing limb surgery. Researchers will collect blood samples and monitor vital signs to build a model that could help doctors adjust doses m…

This study follows about 420 people aged 65 and older who have a certain type of pelvic fracture. Researchers will collect information on their health, treatment, and recovery for up to one year. The goal is to better understand how these fractures affect daily life and mobility.

This study follows 200 people who have broken their pelvis or hip socket to see how they recover over time. Researchers will track when patients return to work and daily activities, and measure changes in physical function, mood, and pain. The goal is to better understand the rec…

This pilot study looks at two ways to treat a specific type of pelvic fracture in people aged 60 and older. One group gets early surgery to fix the bone, while the other group gets rehab without surgery. The main goal is to see if a larger study is possible, not to prove which tr…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung complications after delayed hip fracture surgery in people aged 65 and older. Forty participants will be assigned to one of the two anesthesia types, and their lung function will be measured a…