Ambulance pain drug showdown: ketamine vs fentanyl
NCT ID NCT05437575
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine hydrochloride and fentanyl citrate
What this could lead to
If it works, this could show which painkiller is safer and more effective for trauma patients in ambulances.
What could go wrong
This is a large trial, but results may not apply to all injury types. Both drugs have risks like low blood pressure or breathing problems.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Allegheny Health Network (AHN) Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Atrium Health and Carolinas Medical Center
RECRUITINGCharlotte, North Carolina, 28203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cooper University Health Care
RECRUITINGCamden, New Jersey, 08103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guthrie Robert Packer Hospital
RECRUITINGSayre, Pennsylvania, 18840, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medical College of Wisconsin
SUSPENDEDMilwaukee, Wisconsin, 53266, United States
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The University of Vermont Larner College of Medicine
RECRUITINGBurlington, Vermont, 05405, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Diego
RECRUITINGSan Diego, California, 92103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45267, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Utah
RECRUITINGSalt Lake City, Utah, 84132, United States
Contact Email: •••••@•••••
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Zuckerberg San Francisco General Hospital
RECRUITINGSan Francisco, California, 94110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••