Could whole blood in the ambulance save more trauma patients?
NCT ID NCT04684719
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving low-titer type O whole blood to injured patients at risk of severe bleeding, before they reach the hospital, works better than standard care (fluids or blood components). Over 1,000 patients from 10 trauma centers took part. The main goal was to see if whole blood reduces deaths within 30 days, and researchers also looked at how the age of the blood affects outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
low-titer group O whole blood
What this could lead to
If it works, this could show that giving whole blood early in the field saves more lives than standard fluids or blood components for trauma patients with severe bleeding.
What could go wrong
The trial is complete, but results may not apply to all trauma settings. Whole blood has limited supply and storage age could affect its effectiveness. There are also risks like transfusion reactions or infections.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Metrohealth Systems
Cleveland, Ohio, 44109, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of Cincinatti
Cincinnati, Ohio, 45267, United States
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University of Louisville
Louisville, Kentucky, 40292, United States
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University of Mississippi Medical Center (UMMC)
Jackson, Mississippi, 39216, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
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University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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University of Washington
Seattle, Washington, 98104, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States