Can whole blood save more kids? major trial launches
NCT ID NCT06070350
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two approaches for children under 18 with life-threatening bleeding from trauma. One compares whole blood to standard blood components; the other tests tranexamic acid against placebo. The goal is to see which reduces death within 24 hours. Up to 1,000 children will take part across multiple hospitals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Low Titer Group O Whole Blood (LTOWB) and Tranexamic Acid (TXA)
What this could lead to
If it works, this could establish better transfusion practices to save more children's lives after severe traumatic bleeding.
What could go wrong
This is a large Phase 3 trial, but results may not apply to all settings. Risks include transfusion reactions or unknown side effects of TXA in children.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
Contact
Contact
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Children's Memorial Hermann Hospital
RECRUITINGHouston, Texas, 77030, United States
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Emory University-Arthur M. Blank Hospital
RECRUITINGAtlanta, Georgia, 30329, United States
Contact
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Emory University-Scottish Rite Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
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LeBonheur Children's Hospital
RECRUITINGMemphis, Tennessee, 38103, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84112, United States
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The University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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Tulane School of Medicine
RECRUITINGNew Orleans, Louisiana, 70118, United States
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University of Arizona
RECRUITINGTucson, Arizona, 84719, United States
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University of California Davis
RECRUITINGSacramento, California, 95817, United States
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University of Mississippi Medical Center
RECRUITINGJackson, Mississippi, 39216, United States
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University of New Mexico
RECRUITINGAlbuquerque, New Mexico, 87131, United States
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University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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University of Washington Harborview
RECRUITINGSeattle, Washington, 98195, United States
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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Wake Forest University Health Sciences
RECRUITINGWake Forest, North Carolina, 27157, United States
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Washington University of St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact