Can whole blood save more kids? major trial launches

NCT ID NCT06070350

Recruiting now Disease control Sponsor: Philip Spinella Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 22, 2026 · Updated 5 times

Summary

This study tests two approaches for children under 18 with life-threatening bleeding from trauma. One compares whole blood to standard blood components; the other tests tranexamic acid against placebo. The goal is to see which reduces death within 24 hours. Up to 1,000 children will take part across multiple hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Low Titer Group O Whole Blood (LTOWB) and Tranexamic Acid (TXA)
What this could lead to: If it works, this could establish better transfusion practices to save more children's lives after severe traumatic bleeding.
What could go wrong: This is a large Phase 3 trial, but results may not apply to all settings. Risks include transfusion reactions or unknown side effects of TXA in children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Accidental Injuries injury Shock, Hemorrhagic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMORRHAGIC SHOCK TRAUMA INJURY

Contacts and locations

Locations

Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202, United States
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Children's Hospital of Pittsburgh of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Memorial Hermann Hospital
RECRUITING

Houston, Texas, 77030, United States
Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Emory University-Arthur M. Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Emory University-Scottish Rite Hospital
TERMINATED

Atlanta, Georgia, 30342, United States
LeBonheur Children's Hospital
RECRUITING

Memphis, Tennessee, 38103, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84112, United States
The University of Texas Southwestern Medical Center
TERMINATED

Dallas, Texas, 75390, United States
Tulane School of Medicine
WITHDRAWN

New Orleans, Louisiana, 70118, United States
University of Arizona
RECRUITING

Tucson, Arizona, 84719, United States
University of California Davis
RECRUITING

Sacramento, California, 95817, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87131, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Washington Harborview
RECRUITING

Seattle, Washington, 98195, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences
RECRUITING

Wake Forest, North Carolina, 27157, United States
Washington University of St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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