TRAUMA INJURY

This study tests two approaches for children under 18 with life-threatening bleeding from trauma. One compares whole blood to standard blood components; the other tests tranexamic acid against placebo. The goal is to see which reduces death within 24 hours. Up to 1,000 children w…

This study tests whether a special dye called ICG, used with a new imaging device, can help surgeons see how healthy a patient's bone is during surgery. Ten adults with open fractures or bone infections will receive the dye and be imaged. The goal is to see if this technique can …

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study looks at how older adults (ages 65-74) who live alone and have limb injuries experience recovery. Researchers are testing a special "Geriatric Trauma Care Program" to see if it can improve pain, daily function, mood, and loneliness. About 110 participants will join for…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This study looks at how changing the stiffness of the footplate in a carbon fiber leg brace (called a custom dynamic orthosis) affects foot pressure, walking mechanics, pain, and comfort. Twenty healthy adults will wear the brace with different footplate stiffness levels while re…

This study looks at how severe infections (sepsis) and major injuries change the way the body produces certain immune cells called myeloid cells. Researchers want to understand why these changes can lead to ongoing inflammation and a weakened immune system. The study will follow …

This study looks at what happens to blood and bone marrow after a severe injury. Researchers want to understand why some trauma patients develop a weakened immune system and get serious infections like sepsis. About 255 adults with severe fractures will give blood and a small bon…