TRAUMA INJURY

This study looks at 1,000 children under 18 with life-threatening bleeding from trauma. It compares two transfusion methods—whole blood versus separate blood components—and also tests if a drug called tranexamic acid helps reduce death within 24 hours. The goal is to find the bes…

This study tests a new way to manage pain from broken ribs by freezing the nerves that cause pain. It involves 24 adults with rib fractures who will receive either standard pain care plus the freezing treatment or standard care alone. The goal is to see if this approach is practi…

This study looks at how serious injuries change the way bone marrow stem cells work and how this affects muscle loss and recovery. Researchers will compare trauma patients to healthy people to understand why some patients have long-term problems like anemia and muscle wasting. Th…

This study tests a new imaging device that uses a dye called indocyanine green (ICG) to help surgeons see how well bones are getting blood flow during surgery. The goal is to better predict healing and infection risk in patients with severe fractures or bone infections. About 10 …

This study looks at how severe injuries change the brain, bone marrow, and gut, and how these changes cause long-term anemia and slow recovery. Researchers will study 275 adults with serious blunt trauma to understand these interactions. The goal is to find new ways to help peopl…

This study looks at how the immune system goes wrong in people with sepsis or serious injuries. Researchers will measure certain immune cells in 450 adults to find patterns that lead to ongoing inflammation or immune weakness. The goal is to better understand these problems, not …

This study looks at how changing the stiffness of the footplate in a carbon fiber leg brace changes the pressure on your foot, how you walk, and your comfort. Researchers will test 20 healthy adults walking in braces with different stiffness levels. The goal is to learn how to de…

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…