TRAUMA INJURY

This study aims to find out which emergency airway method works better for seriously injured trauma patients before they reach the hospital. It will compare the standard approach with a newer technique on over 2,000 patients across multiple emergency medical agencies. The main go…

This large, Phase 3 trial aims to find the best way to stop bleeding and save the lives of children with severe traumatic injuries. It will compare giving whole blood versus separated blood components, and test a drug called tranexamic acid (TXA) against a placebo. The main goal …

This study is testing a special camera system that uses a safe, glowing dye to help surgeons see blood flow and health in damaged bones. It aims to give doctors better information to choose the right treatment for people with severe open fractures or bone infections. The goal is …

This is a small, early-stage study to see if a new pain relief method is practical for people with broken ribs. The method, called cryoneurolysis, uses extreme cold to temporarily freeze the nerves that send pain signals from the broken ribs. Researchers will enroll 24 patients t…

This study aims to understand how a special type of carbon fiber leg brace affects walking. Researchers will measure the forces on the foot, how the leg moves, and levels of pain and comfort while participants walk with different brace designs. The goal is to gather knowledge to …

This study aims to understand why older adults have trouble recovering from severe injuries like major fractures. Researchers will compare bone marrow and blood samples from 400 trauma patients, elective hip surgery patients, and healthy people to see how injury changes stem cell…

This study aims to understand why some people don't recover well after a severe infection (sepsis) or major injury. Researchers will observe 450 adults with sepsis or severe trauma to see how their immune system cells change over time. The goal is to learn what causes long-term i…

This study aims to understand how severe physical trauma disrupts communication between the brain, bone marrow, and gut. Researchers will observe 275 adults who have suffered major injuries, along with a smaller group having elective hip surgery for comparison. The goal is to lea…

This study aims to understand what happens to the immune system after severe injuries like car crashes or falls. Researchers will collect blood and bone marrow samples from 255 trauma patients and compare them to people having routine hip surgery. They want to learn why some inju…