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Trauma's hidden toll: scientists map Brain-Bone-Gut damage

NCT ID NCT06606119

Recruiting now Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these interactions so future treatments can be developed to improve recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this research could identify new targets for treatments that improve recovery from severe trauma, especially for persistent anemia and gut health issues.
What could go wrong
This is an observational study, not testing a treatment. It is early-stage research, and findings may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Accidental Injuries anemia Bone Marrow Failure Disorders Critical Illness Inflammation injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE BLOOD LOSS ANEMIA CHRONIC ANEMIA CRITICAL ILLNESS MICROBIOME TRAUMA TRAUMA INJURY

Contacts and locations

Locations

  • UF Academic Research Building

    RECRUITING

    Gainesville, Florida, 32610, United States

  • UF Health at Shands Hospital

    RECRUITING

    Gainesville, Florida, 32610, United States

  • UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF

    RECRUITING

    Gainesville, Florida, 32610, United States

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