TRAUMA

This trial is testing if giving calcium in the ambulance and a hormone called vasopressin early in the hospital can help people with life-threatening bleeding from injuries. It aims to see if these treatments improve survival and reduce the need for blood transfusions. The study …

This study aims to figure out which parts of therapy work best to help children and teenagers recover from post-traumatic stress disorder (PTSD). Researchers will test different combinations of therapy techniques with 200 young participants who have experienced trauma. The goal i…

This study is monitoring the safety and performance of a specialized stent graft device after it has been approved for use in Japan. The device is used to treat dangerous conditions in the body's main chest artery, like aneurysms and tears, while preserving blood flow to a key ar…

This large trial aims to find the best way to replace a key blood clotting factor (fibrinogen) in adults with severe traumatic injuries and major bleeding. It will compare a fast-acting powder (fibrinogen concentrate) that can be mixed at the bedside against the standard frozen b…

This study is testing a flexible therapy approach called FIRST that teaches children and teens skills to manage difficult emotions like anxiety, sadness, and anger. Researchers will compare FIRST to standard therapy for 212 youth ages 7-15 who are struggling with mental health ch…

This study looks back at the medical records of severely injured trauma patients who needed massive blood transfusions. It compares two different drugs (PCC and rFVIIa) used to help the blood clot and stop bleeding. The main goal is to see which drug, if either, is linked to fewe…

This study is testing a liquid material called Onyx LES that is injected to plug and stop active bleeding from arteries in the body (outside the heart and brain), such as from trauma or ulcers. It aims to see if this treatment is safe and effective at controlling the bleeding for…

This study is testing a new medical foam designed to quickly stop life-threatening internal bleeding in the abdomen after serious injuries like car crashes or shootings. The foam is injected and expands inside the body to put pressure on bleeding wounds, buying time for patients …

This study is observing patients who have received a magnesium-based bone filler called Mg OSTEOCRETE. The goal is to see how long it takes for bone to fully heal and regrow after the filler is used to repair defects caused by bone cancer removal, trauma, or loose orthopedic hard…

This study tests whether group therapy for trauma (PTSD) given in prisons can help people after release. It compares group therapy to a self-help workbook to see which better reduces drug use, mental health symptoms, and repeat offenses. The research involves 640 incarcerated peo…

This study is testing whether training maternity doctors to provide more sensitive, trauma-informed care improves the mental health and well-being of pregnant women who survived childhood abuse. It will involve 60 first-time mothers in Argentina and measure their stress, depressi…

This study is testing a therapy program called EMPOWER, designed to support family members who are making difficult medical decisions for a critically ill loved one in the ICU. The goal is to see if this program can reduce symptoms of severe grief, trauma, and regret that these f…

This study is testing a new 12-week therapy program designed to reduce suicide risk in adults who experienced childhood trauma and currently have suicidal thoughts. The therapy combines suicide prevention skills training with trauma-focused treatment. Researchers are enrolling 20…

This study is testing if giving a continuous magnesium drip through an IV can help manage pain in adults who are critically injured and in the ICU. The goal is to see if this common mineral can safely reduce patients' pain scores and their need for strong opioid painkillers. Rese…

This study is testing a pain management plan that avoids strong opioids for people recovering from clavicle fracture surgery. It will compare this new plan, which uses a combination of common pain relievers, to the standard opioid-based treatment. The goal is to see if the nonopi…

This is a small, early-stage study to see if a new pain relief method is practical for people with broken ribs. The method, called cryoneurolysis, uses extreme cold to temporarily freeze the nerves that send pain signals from the broken ribs. Researchers will enroll 24 patients t…

This study is testing a special light-activated bone implant called IlluminOss to see if it helps reduce pain and improve movement in people with pelvic fractures. It's for two groups: cancer patients whose disease has spread to the bone and older adults with fragility fractures.…

This study is creating a data registry to analyze how the order of emergency treatments given before hospital arrival affects survival for patients who suffer cardiac arrest from trauma. Researchers will collect information from about 100 adult patients treated at Methodist Dalla…

This study aims to understand how cannabidiol (CBD) affects the brain and body's response to stress. Researchers will examine 160 young adults who experienced childhood adversity, giving them either CBD or a placebo. The study measures brain activity, stress hormones, and anxiety…

This study is testing if a single dose of the hormone estradiol can help prevent the formation of intrusive, unwanted memories after a stressful experience. Healthy female volunteers will watch a stressful film and then track any upsetting memories that pop up over the next few d…

This study aims to collect and analyze past medical records to understand which surgical approaches work best for traumatic colon injuries. Researchers will review cases from a Dallas hospital trauma registry to compare outcomes of different surgical techniques. The goal is to id…

This study aims to improve how hospitals decide which injured patients need the full trauma team's immediate attention. Researchers are comparing old and new sets of rules (called activation criteria) used by emergency responders to make this call. They will measure how often the…

This study aims to understand how severe physical trauma disrupts communication between the brain, bone marrow, and gut. Researchers will observe 275 adults who have suffered major injuries, along with a smaller group having elective hip surgery for comparison. The goal is to lea…

This study aims to find out which of two simple checklists (called the MGAP score and the GAP score) works better to quickly predict how severely injured patients will fare. Researchers will track 522 patients with multiple injuries at an Iraqi hospital, comparing the scores take…

This study aims to test new, high-tech eye imaging systems that can see microscopic details of the eye, like individual cells and blood flow, which are not visible with standard equipment. Researchers will enroll 1,200 participants, including people with various eye conditions an…

This study is creating a large international registry to collect real-world data on how a medical device called CytoSorb is used in critical care. The device filters harmful substances from a patient's blood and is used for various severe conditions like septic shock, severe trau…

This study aims to understand how doctors decide between major surgery and a less invasive procedure to stop bleeding from spleen injuries caused by trauma. Researchers will analyze existing medical records from 8,000 patients to see which treatments work best for different injur…