TRAUMA

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This study tests a liquid agent called Onyx™ that is injected into arteries to block active bleeding outside the heart and brain. It includes 119 adults with severe bleeding from trauma, ulcers, or other causes. The goal is to see if it safely stops bleeding without needing furth…

This pilot study tests whether giving trauma patients whole blood instead of separate red blood cells and plasma before reaching the hospital is feasible and improves outcomes. About 60 adults with severe traumatic bleeding will be randomly assigned to receive either two units of…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests a bone substitute called Mg OSTEOCRETE in 10 adults with bone defects from tumor removal, loose orthopedic hardware, or trauma. The main goal is to measure how long it takes for the bone to heal after treatment. Researchers will also track patient-reported outcom…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study is checking how well a device called the GORE® TAG® Thoracic Branch Endoprosthesis works for people with a thoracic aortic aneurysm, dissection, or injury. About 200 patients in Japan who receive this stent graft will be followed to see if it is safe and effective. The…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This trial tests a device called ResQFoam, an expandable foam injected into the abdomen to stop severe internal bleeding caused by trauma. The study involves 40 people with life-threatening hemorrhagic shock who need emergency surgery. The goal is to see if the foam can safely ra…

This study tests whether a structured prenatal yoga program can reduce how traumatic women perceive childbirth to be, and improve their self-image and delivery preferences. Forty-six pregnant women in their second trimester or later will attend eight yoga sessions over four weeks…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study aims to find out which parts of behavioral therapy work best for children aged 8-17 with PTSD after a traumatic event. Researchers will compare different therapy components, like emotion regulation and exposure, to a placebo. 200 children and their caregivers will part…

This study looks at how well a special implant (IlluminOss) works for people with pelvic fractures from cancer that has spread or from aging. The goal is to see if it reduces pain and helps patients move better. About 100 adults will be followed for up to 2 years after surgery, r…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study tests a short therapy program called EMPOWER for family members who make decisions for critically ill patients in the ICU. The therapy includes breathing exercises, mindfulness, and coping techniques delivered by a mental health professional. Researchers will compare i…

This pilot study tests whether training obstetric clinicians in trauma-informed care can improve mental health and mother-child bonding in pregnant women who experienced childhood abuse. Sixty first-time mothers in Buenos Aires will receive care from trained providers, and resear…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study will review medical records of 100 trauma patients with colon injuries treated at Methodist Dallas Medical Center. Researchers want to see which surgical approaches lead to the best outcomes. No new treatments are being tested; instead, the goal is to learn from past c…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study looks back at medical records of 5,000 adults who had blunt trauma to the chest or belly area. Researchers want to learn how often the adrenal gland is injured and how that affects recovery. The goal is to better understand this rare injury, not to test a new treatment…

This study looks at why women with PTSD have a higher chance of heart disease later in life. Researchers will test if beetroot juice, a natural source of nitric oxide, can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal is to understa…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study gathers information from trauma patients with a specific type of brain bleed called acute subdural hematoma. Researchers will look at standard surgeries and a newer procedure to see which works best. The goal is to learn from past cases to guide future treatment. No ne…

This study compares two scoring systems, MGAP and GAP, to see which better predicts outcomes like death, hospital stay length, and need for surgery in people with multiple injuries. About 522 adults with trauma will be scored when they arrive at the emergency department, and thei…

This study looks at whether a single dose of estradiol (a hormone) can reduce the number of intrusive, unwanted memories that form after a traumatic event. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The go…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study looks at how cannabidiol (CBD) influences stress in 160 people aged 18-25 who experienced early life trauma. Participants receive either CBD or a placebo, then undergo brain scans and stress tests. The goal is to understand the brain and hormone changes behind CBD's st…

This study looks back at 8000 trauma patients with spleen injuries to figure out the best treatment approach. Researchers want to compare surgery (splenectomy) with a less invasive procedure (embolisation) and see what works best for different injury grades. The goal is to improv…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …