TRAUMA

This study tests a bone filler called Mg OSTEOCRETE in 10 adults who need it to fill bone defects from tumor removal, loose orthopedic hardware, or trauma. The main goal is to see how long it takes for the bone to heal. Researchers will also track patient-reported outcomes and sa…

This study tests whether giving calcium before arriving at the hospital and vasopressin early in the hospital can help people with severe bleeding after a traumatic injury. About 1,050 participants will receive either the drugs or a placebo. The main goal is to see if these treat…

This study tests whether a fast-to-use fibrinogen powder can control bleeding as well as or better than the standard frozen blood product (cryoprecipitate) in severely injured trauma patients. About 900 adults in Australia and New Zealand who need emergency blood transfusions and…

This study tests a special liquid called Onyx™ that hardens into a gel to stop active bleeding in arteries outside the brain and heart. About 119 adults with bleeding from trauma, ulcers, or other causes will receive this treatment. The goal is to see if it safely stops bleeding …

This study tests whether a group therapy for PTSD, adapted for prisons, can help people reduce drug use, mental health issues, and crime after they leave prison. About 640 incarcerated adults across 10 US prisons will either receive the group therapy or a self-help workbook. Rese…

This study tests whether a peer-led program combining acceptance and commitment therapy, exercise, and social support can help women living with HIV improve their medication adherence. The program also addresses substance use, trauma, and violence. Researchers will enroll 300 wom…

This study looks at whether giving trauma patients whole blood before they reach the hospital works better than giving separate blood parts (red cells and plasma). About 60 adults with severe bleeding from injury will take part. The goal is to see if whole blood is easier to carr…

This trial tests ResQFoam, a special foam injected into the belly to stop life-threatening bleeding from injuries. It is for people with severe blood loss who need emergency surgery. The study checks if the foam safely raises blood pressure and controls bleeding until surgery can…

This study is checking how safe and effective a device called the GORE TAG Thoracic Branch Endoprosthesis is for people with a bulging or torn aorta in the chest, or an injury there. About 200 people in Japan will get the device. The goal is to make sure it works well and has few…

This study looks at whether doing yoga during pregnancy can lower a woman's fear of a traumatic birth and improve how she sees herself and her body. Researchers will work with 46 pregnant women who are at least 16 weeks along and have a low-risk pregnancy. The goal is to see if y…

This study looks at which parts of therapy work best to help children aged 8-17 with post-traumatic stress disorder (PTSD) after a traumatic event. Researchers will compare different treatment components to a placebo to see what reduces symptoms most effectively. About 200 childr…

This study tests a new way to manage pain from broken ribs by freezing the nerves that cause pain. It involves 24 adults with rib fractures who will receive either standard pain care plus the freezing treatment or standard care alone. The goal is to see if this approach is practi…

This study tests whether training obstetric doctors in trauma-informed care can improve mental health and mother-baby bonding for pregnant women who experienced childhood abuse. About 60 first-time mothers in Buenos Aires will receive either standard care or care from specially t…

This study tests whether adding extra booster sessions and homework reminders to a short psychological program (PM+) can better reduce stress, anxiety, and trauma symptoms in refugees and asylum seekers. About 1,200 participants aged 16 and older from Swiss communities will take …

This study tests a program called EMPOWER to help family members who make medical decisions for critically ill patients in the ICU. The goal is to reduce their symptoms of grief, PTSD, and depression over the following year. About 172 participants will be assigned to either the E…

This study looks at how well a special implant (IlluminOss) works to reduce pain and improve daily function in people with pelvic fractures caused by cancer spread or aging. About 100 adults will receive the implant as part of their normal care and will report their pain and mobi…

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study tests a 12-week therapy program that combines coping skills with trauma-focused care to help adults who had traumatic childhoods and are currently thinking about suicide. The goal is to see if this approach reduces suicidal thoughts and is practical and acceptable for …

This study compares a nonopioid pain control regimen to standard opioid painkillers in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid approach can manage pain just as well while avoiding opioid side effects. Participants are randomly assigned…

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will analyze the order of treatments given before arriving at the hospital, such as breathing tubes and medications. The goal is to find patterns that could lead to bett…

This study reviews medical records from 5000 adults who had blunt chest or belly trauma to learn how often adrenal gland injury occurs and how it affects recovery. Researchers want to clarify conflicting reports about short-term outcomes. No new treatments are tested; the goal is…

This study looks at why young women with PTSD may have higher heart disease risk later in life. Researchers will give beetroot juice to 30 premenopausal women with trauma exposure to see if it improves blood vessel function. The goal is to understand how PTSD affects the body, no…

This study looks at whether new guidelines for activating trauma care are better than the old ones. Researchers will compare over- and under-triage rates before and after the change. About 5,000 trauma patients at one hospital will be included. The goal is to improve how quickly …

This study looks at how cannabidiol (CBD), a non-intoxicating cannabis compound, affects stress responses in 160 young adults aged 18-25 who experienced early life adversity. Researchers will use brain scans, blood and saliva tests, and stress questionnaires to understand how CBD…

This study looks at medical records from trauma patients with colon injuries to find out which treatments work best. Researchers will review data from 100 adults treated at Methodist Dallas Medical Center. The goal is to improve care for future patients with similar injuries.

This study looks at medical records of 8,000 people who had a spleen injury from trauma. The goal is to understand when doctors choose surgery versus a less invasive procedure to stop bleeding, and which method works best. The study does not involve new treatments—it reviews past…

This study looks at whether taking estradiol (a form of estrogen) can help reduce the number of intrusive, unwanted memories after a traumatic event. Healthy female volunteers will watch a stressful film and then take either estradiol or a placebo. Researchers will track how many…

This study is a registry that gathers information from trauma patients with a type of brain bleed called acute subdural hematoma. Researchers will look at standard surgeries and a newer procedure to see which treatments work best. The goal is to learn from past cases to improve f…

This study compares two scoring systems, MGAP and GAP, to see which better predicts outcomes for people with multiple traumatic injuries. Researchers will assess 522 adults upon arrival at the emergency department and track their hospital course, including survival and length of …

This study looks at how severe injuries change the brain, bone marrow, and gut, and how these changes cause long-term anemia and slow recovery. Researchers will study 275 adults with serious blunt trauma to understand these interactions. The goal is to find new ways to help peopl…

This study looks at trauma patients who need many blood transfusions. It compares two drugs that help blood clot (PCC and rFVIIa) to see which causes fewer dangerous blood clots. The study also checks how long patients stay in the hospital and how many survive. Only 4 adults with…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…