TRAUMA

This trial is testing whether a lab-grown blood vessel made from human collagen can safely replace damaged arteries in people with life- or limb-threatening vascular injuries below the neck. Participants receive the artificial vessel as a bypass or replacement during emergency su…

This study tests whether a custom-designed brace called the IDEO, combined with a physical therapy program called Return to Run, can improve physical function in people with traumatic leg injuries. Participants are adults aged 18 to 60 who are at least two years past a leg injury…

This study tested a new injectable material called acellular adipose tissue (AAT) to repair modest soft tissue defects on the trunk, such as those from injury or surgery. Fifteen adults received one or more injections of AAT, which is made from donated fat cells stripped of their…

This study tested a short, motivational counseling session for injured patients who drink alcohol, delivered in the emergency department in Tanzania. Over 600 adults took part, and the goal was to see if the intervention could reduce binge drinking and related harms. The approach…

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study looked at how safe and effective the JuniOrtho plating system is for treating congenital deformities and fractures in the lower limbs of 30 children and adults. The device is a metal plate and screws used during surgery to hold bones in place while they heal. Researche…

This study looked at whether giving whole blood (all blood parts together) works as well as giving separate blood parts (red cells, plasma, platelets) to people with severe bleeding from trauma. About 200 patients who needed a massive transfusion were included. The goal was to se…

This study tested two common treatments for depression and PTSD—talk therapy (IPT) and an antidepressant (fluoxetine)—in a large public hospital in Kenya. Over 2,100 adults participated to see if these treatments could be effectively delivered by non-specialists in primary care. …

This study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…

This study tests whether watching a custom 360-degree virtual reality video during dressing changes can lower pain, anxiety, and the need for opioid painkillers in adults recovering from burn surgery. Eighty participants will wear VR headsets while their bandages are changed and …

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This study tested a digitally enhanced nursing discharge program for older adults recovering from limb fractures. The program uses interactive digital content and phone follow-ups to teach pain management, coping, and recovery strategies. Researchers compared it to standard care …

This study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty adults participated, and the study focused on whether people would join, complete…

This study tested whether a brain-training technique called neurofeedback could help children aged 6 to 12 who have experienced trauma. Forty children already receiving therapy also did neurofeedback sessions. Researchers measured changes in trauma, depression, and anxiety sympto…

This study tested whether giving nerve pain medications pregabalin or gabapentin alongside standard opioids could lower the amount of opioids needed by adults hospitalized with orthopedic injuries. 109 participants were randomly assigned to receive one of the two add-on drugs. Th…

This study tested whether a program called Equine Assisted Learning (EAL) can reduce trauma symptoms in public safety personnel like police, firefighters, and paramedics. 40 participants from Saskatchewan took part in 16 sessions of unmounted activities with horses, guided by men…

This study tested a 10-session art therapy program for adults with trauma-related symptoms who have difficulty with traditional talk therapy. 38 participants made artwork to process memories and emotions. Researchers measured changes in emotional expression, self-esteem, and resi…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at trauma patients with severe bleeding to understand how early blood transfusions affect their chances of survival and blood clotting. Researchers will compare patients who receive a transfusion within two hours of arrival to those who do not, and also examine t…

This completed study looked at 168 adults with a history of trauma to see if PTSD harms blood vessel function, which could raise heart disease risk. Participants completed behavioral tasks measuring fear and attention, and had their blood vessel health checked. The goal is to und…

This study investigates whether the hormone estradiol influences PTSD symptoms and brain activity related to fear and stress in women. Researchers will give some participants an estradiol patch and others a placebo before MRI scans that measure brain responses to threatening cues…

This study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…

This study looked at whether a 12-hour online training course in psychological first aid (based on the RAPID model) could improve people's communication and listening skills. Ten participants completed the training and were tested before and after. The goal was to see if such tra…

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study looked at whether a simple score called mREMS can predict how trauma patients will do in a hospital in Baghdad. Researchers checked 292 patients with road traffic injuries. They want to see if the score can help doctors in places with limited resources make better deci…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study tested whether a low-dose standing CT scanner can detect early signs of arthritis in people who had an ankle fracture. Researchers followed 97 adults for up to 5 years, measuring joint space changes and pain. The goal was to see if this imaging method could predict ost…

This study looked at 165 trauma patients to see how often they had low blood oxygen (hypoxemia) during their first 24 hours in the hospital. Researchers used a special finger clip to track oxygen levels and compared daytime vs. nighttime episodes. The goal was to understand when …

This study looked at 73 trauma patients in the ICU to see if brainwave (EEG) patterns could predict delirium before it happens. Researchers recorded brain activity over several days and used machine learning to find early warning signs. The goal is to help doctors spot brain prob…

This study created a database of information from nearly 1,000 adult trauma patients with serious arm or leg injuries. Researchers collected details like injury type, treatments, and outcomes to help doctors improve how they save both life and limb. The goal was to learn from pas…

This study tested a digital platform that helps hospital staff quickly identify patients who are bleeding, so they can be asked to join future research studies. About 40 adults admitted to Oxford University Hospitals took part. The goal was to see if the platform could correctly …

This study tested whether an online course can effectively train laypeople in sub-Saharan Africa to provide emergency first aid for trauma injuries. Over 650 commercial drivers in Nigeria, Sierra Leone, Uganda, and Kenya took either an in-person or virtual half-day training cover…

This study looked at how 93 people with spleen injuries from accidents were treated in hospitals in southern France. Researchers tracked deaths, complications, and how long patients stayed in the hospital. The goal was to understand current treatment patterns and outcomes, not to…