New combo therapy aims to cut opioid use in trauma patients

NCT ID NCT04705480

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether giving nerve pain medications pregabalin or gabapentin alongside standard opioids could lower the amount of opioids needed by adults hospitalized with orthopedic injuries. 109 participants were randomly assigned to receive one of the two add-on drugs. The goal was to see if this approach reduces opioid use while still controlling pain effectively.

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Conditions

The condition(s) this trial relates to.

injury opiate dependence Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Charleston Area Medical Center"s Level 1 Trauma Center

    Charleston, West Virginia, 25301, United States