Lab-Grown blood vessels could save limbs after trauma

NCT ID NCT03005418

Completed Disease control Sponsor: Humacyte, Inc. Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial is testing whether a lab-grown blood vessel made from human collagen can safely replace damaged arteries in people with life- or limb-threatening vascular injuries below the neck. Participants receive the artificial vessel as a bypass or replacement during emergency surgery. The study aims to see if the vessel stays open and functioning without additional procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Acellular Tissue Engineered Vessel (ATEV) — a lab-grown blood vessel made from human collagen
What this could lead to: If successful, this could provide a ready-made, off-the-shelf blood vessel for emergency trauma surgery, reducing the need to take a vein from another part of the body.
What could go wrong: This is an early-stage trial with no control group, so results may not prove the vessel is better than standard options. Risks include blood clots, infection, or vessel failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

injury Vascular System Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMA VASCULAR SYSTEM INJURY

Contacts and locations

Locations

Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
Cedars-Sinai Medical Cener

Los Angeles, California, 90048, United States
Cooper University Hospital

Camden, New Jersey, 08103, United States
Duke University Hospital

Durham, North Carolina, 27705, United States
Ernest E Moore Shock Trauma Center at Denver Health

Denver, Colorado, 80204, United States
Grady Memorial Hospital

Atlanta, Georgia, 30303, United States
Jackson South Medical Center

Miami, Florida, 33136, United States
Jacob Medical Center at UC San Diego

La Jolla, California, 92037, United States
Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Keck Hospital of University of Southern California (USC)

Los Angeles, California, 90033, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States
R Adams Cowley Baltimore Shock Trauma

Baltimore, Maryland, 21201, United States
Rutgers New Jersey Medical School

Newark, New Jersey, 07103, United States
Ryder Trauma Center

Miami, Florida, 33136, United States
Saint Louis University (SLU)

St Louis, Missouri, 63110, United States
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Soroka Medical Center - Vascular Surgery Department

Beersheba, 8410101, Israel
Tampa General Hospital

Tampa, Florida, 33606, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The University of Texas - Dell Medical School

Austin, Texas, 78701, United States
UCI Medical Center

Orange, California, 92868, United States
UF Health Jacksonville

Jacksonville, Florida, 32209, United States
University California, Davis

Sacramento, California, 95817, United States
University of California San Diego (UCSD) Medical Center

San Diego, California, 92103, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest School of Medicine

Winston-Salem, North Carolina, 27157, United States

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