Massive registry launched to see if Blood-Filtering device helps sickest patients

NCT ID NCT05146336

Recruiting now Knowledge-focused Sponsor: CytoSorbents, Inc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, shock, and organ failure, but does not test the device against a control group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CytoSorb device (a blood-filtering cartridge used in intensive care)
What this could lead to: If successful, this registry could help doctors understand when and how to best use CytoSorb to improve survival in critically ill patients.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove the device works. Results may be influenced by differences in patient care.

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Conditions

The condition(s) this trial relates to.

acute liver failure acute respiratory distress syndrome Acute-On-Chronic Liver Failure adult acute respiratory distress syndrome burn cardiogenic shock cytokine release syndrome Drug Overdose hemophagocytic syndrome infectious disease infectious disease with sepsis injury Lymphohistiocytosis, Hemophagocytic pancreatitis poisoning Rhabdomyolysis Sepsis Shock, Cardiogenic toxic shock syndrome Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LIVER FAILURE ACUTE RESPIRATORY DISTRESS SYNDROME ACUTE-ON-CHRONIC LIVER FAILURE BURNS CARDIOGENIC SHOCK CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY (CAR-T) CYTOKINE RELEASE SYNDROME (CRS) DRUG OVERDOSE EXTRACORPOREAL LIFE SUPPORT HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSES INFECTIOUS DISEASE LIVER TRANSPLANT; COMPLICATIONS PANCREATITIS POSTOPERATIVE ENDOCARDITIS POSTOPERATIVE VASOPLEGIC SYNDROME RHABDOMYOLYSIS SEPSIS SEPTIC SHOCK TRAUMA

Contacts and locations

Locations

Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum
RECRUITING

Bochum, 44789, Germany
Deutsches Herzzentrum München
RECRUITING

München, 80636, Germany
Helios Dr. Horst Schmidt Kliniken Wiesbaden
RECRUITING

Wiesbaden, 65199, Germany
Herz- und Diabeteszentrum Nordrhein-Westfalen
RECRUITING

Bad Oeynhausen, 32545, Germany
Hospital Juan Ramón Jimenez
RECRUITING

Huelva, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
IRCCS Ospedale Casa Sollievo della Sofferenza
RECRUITING

San Giovanni Rotondo, 71013, Italy
Katholisches Klinikum Bochum, St. Josef-Hospital
RECRUITING

Bochum, 44791, Germany
Kliniken Maria Hilf
TERMINATED

Mönchengladbach, 41063, Germany
Klinikum Herford
RECRUITING

Herford, 32049, Germany
Klinikum Kassel
WITHDRAWN

Kassel, 34125, Germany
Klinikum Klagenfurt am Wörthersee
RECRUITING

Klagenfurt, 9020, Austria
Klinikum Oldenburg
RECRUITING

Oldenburg, 26133, Germany
LMU Klinikum München
RECRUITING

München, Germany
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Ospedale Pediatrico Bambino Gesù
TERMINATED

Roma, 00165, Italy
SP ZOZ Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 30-688, Poland
ULS São José, Hospital Curry Cabral
RECRUITING

Lisbon, Portugal
Unidade Local de Saúde de Coimbra E.P.E
RECRUITING

Coimbra, 3004-561, Portugal
Universitätsklinikum Aachen
RECRUITING

Aachen, 52074, Germany
Universitätsklinikum Essen, Medizinische Intensivtherapie
RECRUITING

Essen, 45147, Germany
Universitätsklinikum Essen, Nephrologie
RECRUITING

Essen, 45147, Germany
Universitätsklinikum Essen, Thorax- und Kardiovaskuläre Chirurgie
RECRUITING

Essen, 45147, Germany
Universitätsklinikum Jena
RECRUITING

Jena, 07747, Germany
Universitätsklinikum Marburg
RECRUITING

Marburg, 35043, Germany
Universitätsmedizin Göttingen, Allgemein-, Viszeral- und Kinderchirurgie
RECRUITING

Göttingen, 37075, Germany
Universitätsmedizin Göttingen, Herzzentrum Göttingen
RECRUITING

Göttingen, 37075, Germany
Uniwersyteckim Spitalem Klinicznym im. Jana Mikulicza - Radeckiego we Wrocławiu
RECRUITING

Wroclaw, 50-556, Poland

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