Poisoning

This pilot study tests whether low-dose colchicine, an anti-inflammatory drug already approved for heart disease, is safe and can reduce inflammation in 30 adults who cannot take statins due to side effects. Participants will take either colchicine or a placebo daily for four wee…

This Phase 2 trial tests a single dose of CS-1103 in 16 healthy adults who also receive fentanyl (a strong opioid) and naloxone (an overdose reversal drug). The goal is to see if CS-1103 is safe and how it affects fentanyl levels in the body. It is an early study to gather safety…

This pilot study tests whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific genetic change (TET2-CHIP). Participants take colchicine or standard care for 12 months. The goal is to see if this genetic marker can guide personalized …

This pilot study is testing whether the anti-inflammatory drug colchicine can lower inflammation and reduce the risk of atrial fibrillation (an irregular heartbeat) after coronary artery bypass surgery. 24 adults scheduled for bypass surgery will be randomly assigned to receive e…

This study follows 600 people in Ethiopia who receive a new type of snakebite antivenom called Premium-PANAF. The antivenom is freeze-dried, so it does not need refrigeration, making it easier to use in remote clinics. Researchers want to see if it safely stops the effects of sna…

This study tests whether showing doctors a warning flag in electronic health records for patients at high risk of opioid overdose can lead to safer prescribing. About 1,350 adults who recently received an opioid prescription will be included. Doctors in some clinics will see a si…

This study is for people with a type of stomach cancer that is H. pylori-positive and can be removed with surgery. It compares standard chemotherapy before and after surgery to the same chemotherapy plus treatment to eliminate H. pylori bacteria. The goal is to see if adding the …

This study tests whether adding all-trans retinoic acid to romiplostim N01 can better raise platelet counts in adults who have low platelets after finishing chemotherapy for gastrointestinal cancers. About 220 participants will receive either the combo or romiplostim alone for 12…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study tests whether a smartphone app called UnityPhilly can help bystanders quickly respond to opioid overdoses with naloxone. About 450 adults who live or work in three Philadelphia neighborhoods will use the app and receive training. Researchers will track how many overdos…

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This study tests a drug called romiplostim N01 in children, adolescents, and young adults (ages 6-24) with cancer who develop low platelet counts from chemotherapy. The drug is given as a weekly shot to help the body produce more platelets. The goal is to see if it can safely and…

This study tests whether a single injection of Telpegfilgrastim works better than daily Filgrastim shots to prevent fever and low white blood cells in children and young adults (ages 6-24) with solid tumors receiving strong chemotherapy. About 132 participants will receive either…

This study is for adults newly diagnosed with a type of acute myeloid leukemia (non-M3). It tests whether adding silibinin, a natural compound from milk thistle that protects the liver, to standard chemotherapy can improve remission rates and survival. About 100 participants will…

This study tests whether colesevelam, a drug used for high cholesterol, can reduce levels of PFAS (forever chemicals) in the blood of firefighters who have high exposure. Fifty male firefighters will take either the drug or a placebo for 12 weeks, then switch. The main goals are …

This study looks at whether cancer survivors who had heart problems from their cancer treatment can safely stop taking heart failure medications once their heart function is back to normal. About 335 adults who have finished cancer therapy and are on heart medications will be ran…

This study tests whether portable air filters can reduce lead dust in older homes and lower blood lead levels in children under 7. About 40 children with elevated lead levels who live in homes built before 1978 will use an air filter in their bedroom for two months. The goal is t…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent kidney damage caused by platinum-based chemotherapy in people with solid tumors. About 46 participants will receive either dapagliflozin or a placebo for a few days around their chemo session. Researche…

This study tests a combination of telehealth, peer support, buprenorphine medication, and connections to addiction treatment programs for people who have had an opioid overdose and visited the emergency department. The goal is to help participants stay in treatment and prevent fu…

This study tests two treatments for a type of bile duct cancer that cannot be surgically removed. One delivers chemotherapy directly to the liver through a pump, and the other uses tiny radioactive beads injected into the tumor's blood supply. Both are given alongside standard ch…

This pilot study is testing whether giving activated charcoal within 6 hours of swallowing a poisonous substance can prevent the poison from getting worse and shorten hospital stays. About 100 adults and children who have ingested a substance that charcoal can absorb will be rand…

This large phase 3 study is testing different combinations of chemotherapy, radiation, immunotherapy, and targeted drugs given before surgery for esophageal cancer. The goal is to find which approach works best to improve survival. The trial will enroll 2,000 adults with stage I …

This study is looking at the best way to treat esophageal cancer that cannot be removed by surgery. It will follow 2,000 patients who receive chemoradiotherapy (radiation plus chemotherapy) along with possible immunotherapy or targeted drugs. The goal is to see which combinations…

This study tests whether using a simple urine test to guide the dose of a water pill (furosemide) can safely and effectively remove excess fluid after heart surgery. About 102 adults having heart surgery with a heart-lung machine will be randomly assigned to either standard care …

This study tests whether taking a low dose of colchicine (a medicine used for gout) every day for a year can prevent the new blood vessels created during heart bypass surgery from failing. About 100 adults who recently had bypass surgery will take colchicine or no extra treatment…

This study tests whether adding chemotherapy to a two-drug combination (camrelizumab and apatinib) helps people with advanced liver cancer live longer without their disease getting worse. About 326 adults with liver cancer that cannot be removed by surgery will participate. The g…

This study explores whether trained volunteers with the overdose-reversal drug naloxone can reach people having an opioid overdose faster than emergency services. About 1,000 volunteers will be alerted via a smartphone app when a suspected overdose is reported. The goal is to see…

This study tests two different ways to give chemotherapy combined with immunotherapy and a targeted drug for people with advanced liver cancer (BCLC stage C). One group gets standard IV chemo plus the drugs camrelizumab and apatinib. The other group gets the same drugs but with c…

This study tests a community program called Young HEROES for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. The goal is to see if this approach works better than usual care in …

This study tests whether the anti-inflammatory drug colchicine, combined with a special surgical technique, can prevent atrial fibrillation (a type of irregular heartbeat) after coronary artery bypass surgery. Researchers will compare 70 patients receiving colchicine plus the new…

This early-stage trial tests an injectable drug called GMDTC in 11 adults with high cadmium levels. The goal is to see if it safely helps the body get rid of cadmium through urine. Participants will receive either the drug or a placebo, and researchers will measure changes in cad…

This phase 2 trial tests two immunotherapy drugs, nivolumab and relatlimab, given before surgery for stage II-IIIa bladder cancer. The goal is to see if the combination can eliminate the tumor, allowing patients to keep their bladder instead of having it removed. About 90 partici…

This study tests a new bedside test that uses a single drop of blood to diagnose methanol poisoning, a major problem in low-income countries. The test measures formate, a toxic byproduct of methanol, and could give results in minutes instead of hours. The trial will first check h…

This study aims to create a simple, fast test (like a pregnancy test) to detect poisonous substances from certain Chinese herbs (aconite) in urine. Current lab tests take too long, delaying treatment. Researchers will test the accuracy of this new device in 90 adults who may have…

This study is testing a new automated MRI method to see if it can take clearer pictures of the liver. It will include up to 200 adults (and some children age 7+) who are healthy, have known or suspected liver disease, or have iron overload. Participants will have one MRI scan, an…

This study checks if a simple finger-prick blood test can accurately detect carbon monoxide poisoning, compared to the usual blood draw from a vein or artery. Researchers will enroll 120 adults with suspected poisoning at an emergency department. If the finger-prick test works we…

This study works with 300 women in rural Kentucky jails who have opioid or stimulant use disorders. The goal is to lower their risk of overdose when they return to their communities. The program offers support and connects them to treatment options before and after release.

This pilot study tests whether a brief overdose prevention education, including naloxone training, is feasible and acceptable for youth ages 13-26 during routine primary care visits. Providers will deliver the intervention to some youth, while others receive usual care. The study…

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. One hundred participants will either receive the shot or standard harm reduction supplies. R…

This study tests whether taking an inactivated (killed) form of the bacterium Bacteroides fragilis can prevent diarrhea caused by chemotherapy. The trial will enroll 200 cancer patients about to start chemotherapy regimens known to cause diarrhea. Participants will receive either…

This pilot study tests whether a peer-driven program can help people who inject drugs in Baltimore reduce their risk of HIV, hepatitis C, and overdose. Researchers will identify high-risk injection settings and train peers to promote safer practices, like carrying naloxone and av…

This study tests whether people who use opioids can be trained as peer educators to teach their friends and family how to prevent overdoses. Researchers will enroll 600 participants in Baltimore and compare those who receive overdose prevention training with those who get standar…

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…

This study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…

This study tests an Arabic-language AI mobile app designed to support women with breast cancer during chemotherapy. The app monitors symptoms, sends medication reminders, and provides educational content. Researchers will compare 130 women who use the app plus usual care to those…

This study tests whether rivastigmine, a drug used for Alzheimer's, can quickly calm agitation and confusion caused by poisoning from medications that block certain nerve signals. About 42 people aged 10 and older with this type of delirium will receive either rivastigmine or a p…

Chemotherapy often causes nausea and vomiting, which is especially hard for children. This study tests a new IV drug called NEPA (fosnetupitant/palonosetron) to prevent these side effects in kids with cancer. The trial has two parts: first, an open-label phase to find the right d…

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Sixteen adults who finished chemotherapy at least 60 days ago will try the therapy at home. The main …

This study tests whether a probiotic supplement can help reduce diarrhea and belly discomfort in breast cancer patients taking the drug Abemaciclib. About 80 participants will get either the supplement or a placebo for two months, while also using standard anti-diarrhea medicine.…

This study looks at whether teaching cancer patients about taste changes caused by chemotherapy and giving them self-management tools can help reduce those symptoms and maintain healthy eating. About 400 adults starting chemotherapy will be split into two groups: one gets standar…

This study tests whether taking alpha-lipoic acid, a natural antioxidant, can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 50 adults with solid tumors will receive either alpha-lipoic acid or a placebo alongside their chemo. Researchers will mo…

This study tests whether playing a serious game on an iPad can help older adults (60+) better manage nausea and vomiting caused by chemotherapy. About 610 participants will be randomly assigned to play the game or receive usual care. Researchers will track symptom severity, quali…

This study tests whether guided imagery—a relaxation technique using calming mental pictures—can reduce nausea and vomiting caused by chemotherapy in children aged 7 to 18 with cancer. Half of the 40 participants will receive guided imagery plus standard care, while the other hal…

This study tests whether adding whole-body vibration exercises to mineral bath therapy (balneotherapy) helps people with chronic low back pain feel better, move easier, and sleep more soundly. Sixty adults aged 18 to 65 with long-lasting back pain will be split into two groups: o…

This study tests whether a combination of two drugs (fosrolapitant and palonosetron) can prevent nausea and vomiting in people receiving strong chemotherapy for the first time. About 200 adults with solid tumors will be enrolled. The goal is to see if this treatment helps patient…

This study is testing whether squeezing a stress ball during chemotherapy can help reduce nausea, anxiety, and fatigue in people with stomach cancer. About 52 adults will take part. Researchers will measure their symptoms during treatment to see if this simple, drug-free tool mak…

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug (dexamethasone), can prevent or reduce nausea and vomiting caused by chemotherapy in breast cancer patients. About 25 women will receive this treatment before chemo and track their s…

This study tests whether combining ear acupressure (using small seeds on specific ear points) with the steroid dexamethasone can better prevent or reduce nausea and vomiting caused by chemotherapy in pancreatic cancer patients. About 25 participants will receive the treatment bef…

This study tests whether regular massage therapy can improve sleep for children aged 12-21 who are hospitalized for cancer treatment or stem cell transplant. Seventy participants will either receive standard care or a 20-30 minute massage five days a week for three weeks. Sleep w…

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests whether regular phone or video calls from a trained oncology nurse can help breast cancer patients on CDK inhibitor drugs catch and manage side effects early. About 124 women will be randomly assigned to either standard care or standard care plus structured telen…

This early-stage study tests a new drug called KAN-004 in 21 adults who have diarrhea or colon inflammation from cancer immunotherapy. The main goal is to see if the drug is safe and tolerable. Participants must have a solid tumor and be at least 18 years old.

This early-phase trial tests whether the drug romiplostim can prevent dangerously low platelet levels caused by chemotherapy in children and young adults with newly diagnosed Ewing sarcoma. About 26 participants will receive romiplostim alongside their standard chemotherapy to se…

This study tests whether a computer model can predict vomiting in children with cancer who are in the hospital. The model uses each child's medical information to estimate their risk of vomiting in the next 96 hours. Doctors and pharmacists will use this information to give extra…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This study looks at whether socio-aesthetic care (like skincare and makeup sessions) can lower anxiety in cancer patients who are starting chemotherapy. About 192 people who have never had chemo before will take part. Researchers will measure their anxiety levels before treatment…

This study tests whether a mobile cognitive training app can reduce 'chemobrain'—memory and thinking problems caused by chemotherapy—in people with gynecologic cancers. Sixty-four participants will use the app on their own phones while undergoing chemotherapy and complete thinkin…

This study tests whether a granisetron skin patch works better than ondansetron pills for preventing nausea and vomiting in people getting chemotherapy before a stem cell transplant. About 90 patients will be enrolled and randomly assigned to one of the two treatments. The goal i…

This early-phase trial tests a topical phenylephrine gel applied daily to the scalp for three weeks. Researchers want to see how much of the drug enters the bloodstream and whether it is safe. The study involves 24 healthy women aged 18-55, not cancer patients, so it is a first s…

This study compares two schedules for taking non-opioid pain relievers (acetaminophen and NSAIDs) after a cesarean delivery: taking them at different times (staggered) or at the same time (simultaneous). The goal is to see which approach better controls pain and reduces the need …

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

This pilot study looks at how different types and intensities of exercise affect muscle recovery in people taking statins compared to those not on statins. Researchers will test cycling and resistance training at various levels, measuring muscle damage markers and pain sensitivit…

This study tests whether a 4-week ketogenic diet changes how the brain responds to alcohol. Twenty adults will follow the diet and undergo alcohol tolerance tests and brain scans before, during, and after the diet. The goal is to understand how ketosis affects alcohol metabolism …

This study looks at how two common medicines, paracetamol (a painkiller) and cefazolin (an antibiotic), move through the bodies of children aged 2 to 15 who are either normal weight or overweight. The goal is to see if standard doses work the same way in both groups. About 120 ch…

This study looks at whether a device that measures pupil reactions can help identify children at risk for opioid-induced respiratory depression after tonsillectomy. About 300 children will have their pupils measured before, during, and after surgery. The goal is to see if pupil p…

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This study follows 500 adults who received a stem cell transplant at least 10 years ago to see if iron buildup in the body raises the risk of liver problems. Researchers will use blood tests and a special liver scan (FibroScan) to check for damage. The goal is to understand wheth…

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This pilot study looks at whether changes in gut bacteria are linked to fatigue and nausea in women with early-stage breast cancer undergoing chemotherapy. Researchers will collect stool and blood samples and have participants fill out questionnaires before and after treatment. T…

This study looks at whether giving paracetamol through a vein during emergency belly surgery causes a drop in blood pressure. Researchers will monitor 90 adults having this surgery to see how their blood pressure changes. The goal is to help doctors choose safer pain relief optio…

This study is building a Canada-wide registry of people who come to emergency departments with opioid poisoning. Researchers will track treatments and outcomes for up to 7,200 patients. The goal is to learn what works best and create a tool to predict who is at highest risk of dy…

This study explores whether cancer patients can safely monitor their own blood counts at home during chemotherapy. About 265 participants from Denmark, Poland, and Germany will test a home monitoring device for several cycles. The goal is to reduce unnecessary hospital visits, lo…

This study is testing a new way to reduce opioid overdoses on Chicago's West Side. Researchers will train friends and family members of people who use opioids to become harm reduction champions. These champions will learn about tools like naloxone and fentanyl test strips, and th…

This study looks at whether environmental factors like heavy metals from gold mining, past viral infections, or traditional plant remedies are linked to peripheral neuropathy (nerve damage) in French Guiana. Researchers will compare 78 people with and without nerve damage to see …

This study watches 363 people with stab or gunshot wounds to the belly to see if alcohol, drugs, or pain medicine changes how fast doctors decide on surgery. It does not test any new treatment—just observes what happens in two hospitals in Colombia. The goal is to learn if these …

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body…

This study tests two first aid methods for snake bites: the standard pressure bandage and a simpler pressure pad. Twenty-four healthy volunteers will receive a mock venom injection in their hand or foot, and a gamma camera will track how fast it moves through the body. The goal i…

This study tests whether placing 15 houseplants in two hospital lab rooms can reduce formaldehyde levels in the air and in workers' urine. Formaldehyde is a toxic chemical used to preserve tissue samples. Thirty adult lab staff will have their exposure measured before and two mon…

This study looks at how drinking alcohol and the way couples talk about sex can lead to sexual violence between partners. Researchers will bring in 240 couples from the Denver area to a lab, where some will drink alcohol and others won't, and then test their reactions. The goal i…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study examines patients in intensive care who have overdosed on metformin, a common diabetes drug. Researchers will compare those who took only metformin with those who also took dapagliflozin, another diabetes medication. The goal is to find specific signs that could help d…

This study will use data from NYC homeless shelters, Medicaid, and vital records to see if harm reduction programs reduce fatal and non-fatal overdoses. Researchers will also look at whether these programs help people start treatment for substance use disorder and use health serv…

This study looks at how using vaporized cannabis and drinking alcohol together affects thinking, coordination, and driving skills. About 90 healthy adults will take part in sessions where they receive different doses of cannabis (THC) and alcohol or placebos. Researchers will mea…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …