Poisoning

This pilot study aimed to help people who had an opioid overdose by starting them on buprenorphine/naloxone in the emergency room and then connecting them to an addiction clinic. The goal was to reduce repeat overdoses and improve treatment engagement. However, the study was with…

This study looks at whether using a high-efficiency air filter in the bedroom overnight can reduce inflammation and heart-related risks in adult cancer survivors living in highly polluted areas. Ten participants will each try both filtered and unfiltered air for two-week periods,…

This study tests whether a simple program—including an education session for oral surgeons, patient instruction sheets, and blister packs of acetaminophen and ibuprofen—can reduce opioid prescriptions to adolescents and young adults after tooth extraction. About 38,000 patients a…

This study tests a trauma-informed program called TRUST for women leaving prison who have a history of substance use and violent victimization. The program includes individual and group sessions to build skills and support recovery. Researchers will measure changes in substance u…

This study tests whether rivastigmine, a drug used for Alzheimer's, can prevent delirium from coming back after initial treatment with physostigmine for anticholinergic poisoning. About 42 people aged 10 and older with controlled delirium will receive either rivastigmine or a pla…

This study looks at whether placing naloxone—a medication that reverses opioid overdoses—in vending machines makes it easier for people in the community to get it. Researchers will track how many naloxone kits are distributed before and after installing the machines. Anyone in th…

This study tests a computer alert that reminds doctors to prescribe naloxone—a drug that reverses opioid overdoses—alongside high-risk opioid prescriptions. The alert appears when a doctor orders an opioid for patients aged 12-89 (excluding those with cancer or hospice care). Res…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This study tests a program where trained peers use motivational interviewing to encourage people who use drugs to check their drugs for dangerous substances and adopt safer use behaviors. The goal is to reduce fatal and non-fatal overdoses, as well as HIV and hepatitis C infectio…

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This study tests a combination of two drugs—rhTPO and hetrombopag—to raise platelet counts in 100 cancer patients whose platelets dropped due to chemotherapy. Patients are split into two groups based on how low their platelets are, and both groups receive the same drug combo unti…

This study looks at whether blood-filtering treatments, such as dialysis or plasma exchange, can help people survive acute poisoning. Researchers will compare over 5,000 poisoned patients who received these treatments with those who did not. The goal is to see if the treatments i…

This trial aimed to see if adding intralipid (a fat emulsion given through a vein) to standard care could help people poisoned by organophosphorus compounds, which are found in some pesticides. The plan was to compare hospital stay length and death rates between 30 patients getti…

This study is testing an artificial intelligence system that can identify snake species from photos taken by patients or witnesses. The goal is to help emergency doctors quickly know whether a snake is venomous and which species it is, so they can give the right treatment faster.…

This study was designed to test whether an oral drug called SPI-1005 could prevent hearing loss and ringing in the ears caused by platinum-based chemotherapy. It was planned for adults with advanced lung or head and neck cancer. The study was withdrawn before enrolling any partic…

This study tests whether romiplostim can prevent chemotherapy delays or dose reductions caused by low platelet counts in people with lung, ovarian, or breast cancer. About 145 adults will receive either romiplostim or a placebo alongside their chemotherapy. The goal is to help pa…

This study tests whether a personalized care plan, based on a geriatric assessment, can reduce severe side effects in older adults (65+) starting chemotherapy for common cancers. Participants are randomly assigned to receive the assessment-driven plan plus usual care, or usual ca…

This study tests whether a relaxation breathing exercise can help reduce nausea and vomiting caused by chemotherapy in people with blood cancers. Sixty-eight patients are split into two groups: one does breathing exercises three times a day plus standard care, the other gets stan…

This pilot study tests whether aromatherapy inhaler sticks can reduce nausea and vomiting in 30 patients receiving chemotherapy as part of a stem cell transplant. Participants use the inhaler every four hours and whenever they feel sick. Half get essential oils, half get a placeb…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study looks at whether teaching people who use drugs how to use fentanyl test strips can help prevent overdoses. About 2,400 adults in Ohio will take part at Project DAWN sites. Some will get the test strip education, while others will just get the usual overdose prevention …

This study looks at how alcohol changes brain activity when people interact with each other. Researchers will use special brain scans (EEG) on pairs of people while they drink and do tasks. The goal is to understand the brain processes behind alcohol's social effects. 240 adults …

This study looks at whether a package of tools and support can help staff and tenants in 20 supportive housing buildings in New York adopt proven overdose prevention practices. Researchers will survey tenants and staff, observe what happens, and check health records to see if the…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study looks at how being in ketosis (a state from a very low-carb diet) changes the way the body processes alcohol and affects the brain. About 23 healthy adults will follow three different 3-day diets and then drink 4-5 alcoholic beverages. Researchers will use breath tests…

This study aimed to adapt an opioid overdose education and naloxone distribution program for Black church members, including clergy, people with opioid use disorder, and their families. The goal was to reduce stigma and increase overdose reversal skills. However, the trial was wi…

This study was designed to see if a special breathing technique called isocapnic hyperventilation could help remove methanol from the blood of poisoned patients, similar to dialysis. Researchers planned to give the antidote fomepizole and use a breathing device while measuring me…

This study looks at how the tumor microenvironment changes during chemotherapy in 30 patients with HER2-positive breast cancer. Researchers will take samples before, during, and after treatment to see what happens at the cellular level. The goal is to better understand how chemot…

This study looks at whether genetic differences change how well exercise works for people taking statins. Five overweight or obese adults on high-dose atorvastatin will do supervised exercise for 6 weeks. Researchers will measure fitness changes and link them to each person's gen…

This study uses stem cells made from patients' own cells to understand why some people develop severe heart or lung side effects from certain chemotherapy drugs. Researchers will compare cells from patients who had extreme toxicity to those who did not. The goal is to uncover the…

This study tracks 193 people who swallowed the herbicide diquat to see how the amount of poison in their blood relates to damage in organs like the brain. Researchers will also look at how well blood-filtering treatments work. The goal is to better predict who is at highest risk …

This study looks at whether lead stored in bones is linked to worse mental health or weaker responses to brain stimulation therapies like TMS and tDCS. Researchers will test bone lead levels in 500 psychiatric patients and compare them with cognitive tests and psychiatric symptom…

This study looks at how well medical teams follow safety guidelines when treating people hurt in a chemical, biological, or nuclear attack. Researchers will track 1,000 patients to see if care is given without delay and if contamination is controlled during rescue. The goal is to…

This study looks at 200 adults with solid tumors who are getting chemotherapy. Researchers will compare four different checklists (PG-SGA, MUST, Nutriscore, and GLIM criteria) to see which best identifies malnutrition and muscle loss. The goal is to find the most reliable tool so…