Poisoning

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tested a chemotherapy drug called trifluridine/tipiracil in 52 women with advanced ER-positive, HER2-negative breast cancer that had already been treated with other chemotherapies. The goal was to see if the drug could slow cancer growth and improve quality of life. Th…

This study tested whether cooling the body to 33°C for 24 hours, combined with hyperbaric oxygen therapy, improves brain recovery in adults with severe carbon monoxide poisoning. 37 participants were randomly assigned to either therapeutic hypothermia or normothermia (keeping bod…

This study tested a new drug called GMDTC in 160 adults with high cadmium levels. The goal was to see if removing cadmium from the body could improve mood, thinking, and pain. Participants received the drug and were monitored for changes in cadmium levels and mental health scores…

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking behavior and reduces exposure to harmful chemicals. 372 daily smokers who were not planning to quit were given e-cigarettes to use freely for 12 weeks, then c…

This study tested whether a pharmacist-led program could help people leaving jail get treatment for opioid use disorder and prevent overdoses. Participants received overdose training, Narcan nasal spray, counseling, and referrals to medication treatment after release. The goal wa…

This completed Phase 2 trial tested whether a special DNA-based test could predict how well patients with stomach or rectal cancer respond to immunotherapy (tislelizumab) combined with chemotherapy and/or radiation. 189 adults with advanced cancer participated. The goal was to se…

This study tested whether giving acetaminophen (a common pain and fever medicine) to extremely preterm babies within the first 12 hours after birth can help close a blood vessel in the heart that normally closes on its own. The trial involved 804 babies born between 23 and 28 wee…

This study tested whether deferiprone, a drug that removes excess iron, could safely slow the progression of ALS. Researchers gave the drug to 23 adults with ALS for several months. The goal was to see if reducing iron buildup in the brain might protect nerve cells and delay wors…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were receiving chemotherapy. The goal was to see if romiplostim could prevent low platelet counts (thrombocytopenia) that often force doctors to delay or reduce c…

This study tested two different ways of giving scorpion antivenom to adults who were stung. One group got a dose based on how severe their symptoms were, while the other group got the same dose for everyone. The goal was to see if the simpler approach works just as well at reliev…

This early-phase study tested whether the heart medication carvedilol could safely protect breast cancer patients from heart damage caused by chemotherapy drugs like doxorubicin and trastuzumab. 68 women with early-stage breast cancer were assigned to either receive carvedilol or…

This study tested whether adding magnesium sulfate or nimodipine (drugs usually used for heart conditions) to standard treatment could help people who poisoned themselves with pesticides. Over 1,700 adults in medical wards were enrolled. The main goal was to see if these drugs re…

This study looked at how well and how safely the antivenom Inoserp Pan-Africa® works for snake bites in everyday hospital settings in Cameroon. Researchers followed 474 patients over 5 years old who came to participating centers after a snake bite. The goal was to check for aller…

This study looked at 100 children with beta-thalassemia major and iron overload to see if simple blood tests (ferritin and hepcidin) can detect liver scarring (fibrosis) as accurately as other non-invasive methods. Researchers measured these blood markers and compared them to ult…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether adjusting the dose of a tuberculosis (TB) prevention drug based on a person's genetic makeup could improve treatment. Researchers enrolled 78 people and used a quick genetic test to guide the dose of isoniazid. The goal was to see if this personalized ap…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study looked at whether giving different doses of magnesium can help prevent kidney damage caused by the chemotherapy drug cisplatin. 100 people with head and neck cancer took part. Researchers compared three groups receiving 1, 2, or 3 grams of magnesium to find the best pr…

This study looked at whether giving fentanyl test strips and naloxone to people in Ohio drug courts could help prevent overdoses from stimulants mixed with opioids. Over 650 adults who used stimulants in the past 6 months took part. Researchers tracked how many people used the ki…

This study tested a new system called the Opioid Rapid Response System (ORRS) that uses a smartphone app to train and alert everyday people to respond to opioid overdoses with the life-saving drug naloxone. Over 700 adults from communities using the PulsePoint app took part. The …

This study tested a household safety intervention for veterans with elevated suicide risk. The program involved discussions about safely storing firearms and medications, plus providing free safety devices. Researchers enrolled 40 veterans from VA healthcare settings to see if th…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study tested whether adding dexmedetomidine or dexamethasone to a local anesthetic mixture improves pain control and patient satisfaction during cataract surgery. 75 adults undergoing eye surgery received one of the two additives or a placebo. The main goal was to see how lo…

This study looked at whether adding magnesium sulfate to a standard numbing medicine (bupivacaine) in a nerve block could improve pain control after a mastectomy. Seventy women having breast cancer surgery received either the standard nerve block or one with added magnesium. The …

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

This study tested whether a nerve block (fascia iliaca block) given before spinal anesthesia helps patients with hip or upper thigh fractures get into a comfortable position. Forty patients were randomly assigned to receive either the nerve block with bupivacaine or a placebo (sa…

This study tested whether coloring mandala patterns can reduce nausea, vomiting, and fatigue, and improve psychological well-being in cancer patients receiving chemotherapy. 85 patients were split into a coloring group and a control group. The coloring session lasted 20-30 minute…

This study tested whether colchicine, an anti-inflammatory drug, can lower inflammation in people with a specific type of heart failure called HFpEF. 42 adults with heart failure symptoms and signs of inflammation took part. The goal was to see if colchicine could reduce markers …

This study tested whether using less dexamethasone (a steroid) along with two other anti-nausea drugs (NEPA and olanzapine) works as well as the standard full-dose steroid approach. 644 adults receiving strong chemotherapy were enrolled. The goal was to see if the reduced-steroid…

This study tested whether using a low-frequency laser on an acupuncture point (P6) can help prevent nausea and vomiting caused by chemotherapy in children aged 2 to 20. The 30 participants received the laser treatment alongside standard anti-nausea drugs. The goal was to see if a…

This pilot study tested a smartphone app that lets breast cancer patients on oral chemotherapy report side effects and get basic advice. Hospital pharmacists were alerted when needed. The goal was to see if the app could improve monitoring and reduce phone calls. Only 28 patients…

This study tested two numbing medicines for children's eye exams: a gel (chloroprocaine) and eye drops (oxybuprocaine). 74 children aged 0-17 received one of the two before their eye exam. Researchers checked how well each numbed the eye and if there were any side effects.

This phase 3 trial tested whether a new drug called APF530, given as a shot under the skin, works better than the standard drug ondansetron for preventing nausea and vomiting after strong chemotherapy. About 942 cancer patients took part. The study compared both drugs when combin…

This study compared two exercise programs—thoracolumbar stabilization exercises and spinal decompression exercises—in 26 adults with Maigne's syndrome, a condition causing pain at the junction of the lower back and upper buttock. Participants did their assigned exercises three ti…

This study tested two different numbing creams to see which one works better for pain during a laser skin treatment. 22 adults with sun-damaged skin tried both creams on different sides of their face. The goal was to find which cream provides better pain relief and fewer side eff…

This study tested whether pentoxifylline, a drug used for blood flow problems, can protect the kidneys from damage caused by cisplatin chemotherapy in head and neck cancer patients. 90 adults receiving cisplatin for the first time took part. Researchers measured kidney injury usi…

This study tested whether putting lignocaine (a numbing medicine) inside the abdomen during gynecologic open surgery can reduce pain afterward. 112 women having surgery like hysterectomy or cystectomy took part. The goal was to see if this approach lowers pain scores and the need…

This study tested whether wearing virtual reality glasses to visit a museum during chemotherapy could help reduce pain, fatigue, and anxiety. 64 patients were split into two groups: one received routine care, while the other also took a 20-minute virtual museum tour each week for…

This study tested whether taking Coenzyme Q10, a natural antioxidant, can help prevent or reduce side effects from chemotherapy in breast cancer patients. Forty women newly diagnosed with breast cancer and about to start chemotherapy took either Coenzyme Q10 or a placebo. Researc…

This study tested whether inhaling geranium essential oil during chemotherapy can reduce pain and blood pressure in cancer patients. 90 Indonesian patients under 65 with normal weight took part. The treatment group breathed in geranium oil for 15 minutes during chemo, while the c…

This study tested whether inhaling geranium essential oil can reduce nausea and vomiting in cancer patients receiving chemotherapy. 90 participants were randomly assigned to either inhale geranium oil during chemo or receive no aromatherapy. Nausea and vomiting were measured befo…

This study tested if the drug Akynzeo can prevent nausea and vomiting in cancer patients getting moderate chemotherapy who are at high risk based on a special prediction tool. Over 400 adults took part. The goal was to see if Akynzeo works better than standard care over three rou…

This study tested Sujok therapy, a technique where seeds are placed on specific points on the hands, to see if it reduces pain and anxiety in cancer patients getting a port catheter for chemotherapy. 90 patients were split into three groups: one received real Sujok, one received …

This study tested a new medicine called QLM2010 to see if it can prevent nausea and vomiting caused by strong chemotherapy. 665 adults with solid tumors who had never had chemo before took part. The goal was to see if QLM2010 works better than current standard drugs at stopping v…

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This pilot study tested a training called Crisis Ready for people in a Baltimore diversion program. The training teaches how to use a crisis hotline and how to give naloxone to reverse an overdose. Researchers wanted to see if participants found the training likable and useful. O…

This study tested how a new form of nalmefene (a drug that reverses opioid overdoses) behaves in the body when given as a shot or through an IV. 13 healthy adults received single doses of both the new and standard versions. The goal was to see how quickly the drug reaches the blo…

This study looked at 25 people who came to medical tents at music festivals in Aquitaine, France, with signs of drug poisoning. Researchers took small blood, hair, and urine samples to identify which psychoactive substances they had taken. The goal was to track which drugs are ci…

This study looked at 58 young adults aged 18-29 who regularly use e-cigarettes. Researchers measured heavy metals in their saliva and tested their lung function before and after a 30-minute vaping session. The goal was to understand how vaping exposes the body to metals and affec…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study tested two virtual, culturally-tailored programs to help Alaska Native youth (ages 14-24) who were hospitalized for suicide attempts, suicidal thoughts, or alcohol-related injuries. Researchers compared how well each program reduced suicide risk, depression, anxiety, a…

This study tested whether a special MRI scan (31P-MRS) can detect early signs of damage to heart and muscle cells caused by chemotherapy drugs like doxorubicin. Twelve cancer patients scheduled for chemo underwent three scans over time. The goal was to see if the scan could measu…

This study looked at whether exercise training can improve physical capacity and heart function in adults who survived Hodgkin lymphoma after chemotherapy and chest radiation. Forty survivors took part in fitness tests and heart monitoring. The goal was to see if exercise could r…

This study tested whether teaching people about alcohol flushing and giving them genetic test results could reduce drinking. 70 adults who were native English speakers took part. Researchers measured awareness and alcohol consumption before and after the education.

This study tested a new device (AP003) that delivers naloxone as a nasal spray to reverse opioid overdoses. Twenty-four healthy adults received multiple doses to see how the drug moves through the body and to check for side effects. The goal was to compare the new spray with an e…

This study tested a predictive analytics tool called PROVIDENT to forecast where overdose deaths might happen next. Researchers randomly assigned 39 Rhode Island municipalities to either use the tool or continue with standard prevention efforts. The goal was to see if directing r…

This completed observational study from Latvia looked at whether statin-related muscle symptoms are linked to problems in fat metabolism in muscle cells. Researchers measured acylcarnitine levels in blood and muscle samples from 38 adults, comparing those with statin-related musc…

This study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how t…

This study looked at different digital scanning methods for taking impressions of dental implants when the usual scanning parts are not available. Twelve adults with partial tooth loss and two dental implants took part. Researchers compared three digital workflows to see which ga…

This study watched 225 people with solid tumors who got a drug called G-CSF during chemotherapy. G-CSF can cause bone pain. Researchers measured pain levels and tracked what treatments (like pain relievers or other methods) helped. They also checked quality of life, fatigue, mood…

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study reviewed medical records of over 3,000 people treated for scorpion stings in Mexico. It looked at how using home remedies and waiting longer to get care affected symptom severity and the amount of antivenom needed. The goal is to help doctors use antivenom more wisely …

This study tested a web-based program called RealConsent2.0, designed to help young men (ages 21-25) recognize and safely intervene in situations that could lead to sexual violence, especially when alcohol is involved. Over 600 men participated, and their bystander behavior was m…

This study looked at how stress influences the choice to drink alcohol in 160 regular drinkers. Participants were randomly assigned to stress or no-stress conditions and then completed a decision-making task choosing between alcoholic and non-alcoholic drinks. The goal was to und…

This study tested whether a machine learning model could predict kidney injury caused by platinum chemotherapy more accurately than doctors. Researchers followed 77 cancer patients receiving cisplatin or carboplatin, tracking their kidney function over time. The goal was to see i…

This study tested whether a special belt that creates images of the lungs (Electrical Impedance Tomography) can safely help doctors choose the best pressure settings on a breathing machine for infants under 3 years old. The study included 14 children with various serious conditio…

This completed study tracked 107 adults in Ghent who suspected they had been spiked. Researchers collected urine and blood samples to identify the substances involved and how they were given. The goal was to document how common spiking is and where it happens, without testing any…

This study looked at how paracetamol (a common painkiller) is processed in the body after major liver surgery. Researchers measured paracetamol levels in the blood over five days in 90 patients who had different amounts of liver removed. The goal was to understand if patients wit…

This study looked at how chemotherapy impacts the quality of life of women treated for stage II or III endometrial cancer. Researchers asked 51 patients to fill out questionnaires about their physical, emotional, and social well-being at least two years after finishing treatment.…

This study looked at how alcohol changes attention in 92 young adults aged 21-25 who drink regularly. Participants completed simple phone-based tasks before and after drinking a standard amount of alcohol in the lab, and also answered surveys on their phones over eight weekends. …

This study looked at over 36,000 adults in the UK to see if people with vitiligo are more likely to have mental health problems like depression, anxiety, or self-harm compared to those without vitiligo. Researchers used medical records to compare risks and also checked if these r…

This completed study in Egypt examined 1,000 adults with heart disease to see how many reached their LDL cholesterol targets and what got in the way. Participants provided a fasting lipid profile, and researchers looked for patterns and barriers. The goal is to find better ways t…

This study looked at how accurately patients with alcohol intoxication in the emergency department estimate their own blood alcohol concentration (BAC) compared to a real blood test. Researchers enrolled 34 adults aged 15-64 with a BAC of 60 mg/dL or higher. The goal was to see i…

This early study tested single doses of HOPO 14-1 in 42 healthy adults to see if it is safe and how the body handles it. HOPO 14-1 is designed to bind and remove toxic metals like uranium or plutonium. The trial was completed, but results are not yet available.

This study looked at how eating cannabis (in a brownie) and drinking alcohol, alone or together, affects people's ability to think clearly, stay coordinated, and drive safely. Sixty healthy adults aged 21 to 55 took part in a controlled lab setting. Researchers measured impairmen…

This study looked at how the body processes ropivacaine, a numbing medicine, when given as a nerve block for chest surgery. Twenty adults having robotic or video-assisted chest surgery received the block, and researchers measured drug levels in their blood to check for toxicity. …

This study measured blood flow in the skin of 62 people, including cancer patients who received 5-FU chemotherapy, those on other treatments, cancer survivors, and healthy controls. Researchers used a non-invasive laser sensor to see how small blood vessels responded to substance…

This study looked at how anthracycline-based chemotherapy affects blood vessel health and blood pressure control in 60 people with breast cancer or lymphoma. Researchers measured artery stiffness, blood flow, and skin blood vessel responses. The goal is to understand why cancer s…