Cooling therapy may shield brain after CO poisoning
NCT ID NCT04975867
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether cooling the body to 33°C for 24 hours, combined with hyperbaric oxygen therapy, improves brain recovery in adults with severe carbon monoxide poisoning. 37 participants were randomly assigned to either therapeutic hypothermia or normothermia (keeping body temperature normal). The goal was to see if cooling reduces long-term neurological damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
targeted temperature management (therapeutic hypothermia or normothermia) combined with hyperbaric oxygen therapy
What this could lead to
If it works, this could point toward a better way to prevent long-term brain damage after severe carbon monoxide poisoning.
What could go wrong
This is a small, early-phase trial with only 37 participants, so results may not apply to everyone. The treatment involves cooling the body, which carries risks like infection or heart issues.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Inha University Hospital
Incheon, Incheon, 22332, South Korea
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Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426, South Korea