Cooling therapy may shield brain after CO poisoning
NCT ID NCT04975867
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether cooling the body to 33°C for 24 hours, combined with hyperbaric oxygen therapy, improves brain recovery in adults with severe carbon monoxide poisoning. 37 participants were randomly assigned to either therapeutic hypothermia or normothermia (keeping body temperature normal). The goal was to see if cooling reduces long-term neurological damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- targeted temperature management (therapeutic hypothermia or normothermia) combined with hyperbaric oxygen therapy
- What this could lead to
- If it works, this could point toward a better way to prevent long-term brain damage after severe carbon monoxide poisoning.
- What could go wrong
- This is a small, early-phase trial with only 37 participants, so results may not apply to everyone. The treatment involves cooling the body, which carries risks like infection or heart issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CARBON MONOXIDE POISONING are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Inha University Hospital
Incheon, Incheon, 22332, South Korea
-
Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, 26426, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Chilled saline infused directly into brain during stroke treatment may limit damage
- A simple body mark may help doctors place temperature probes accurately every time
- Warming blankets before surgery may keep patients safer
- Warm blankets beat shivers before heart surgery
- CO poisoning treatment study cut short after only two patients
- Could a pill boost performance in extreme cold and thin air?