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Chilled saline infused directly into brain during stroke treatment may limit damage

NCT ID NCT06485427

Completed Disease control Sponsor: Beijing Shijitan Hospital, Capital Medical University Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either standard clot removal alone or standard care plus the cooling infusion. The main goal is to see if cooling leads to better functional outcomes three months after the stroke.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cold saline infusion
What this could lead to
If it works, this cooling method could reduce brain damage and improve recovery after a severe stroke.
What could go wrong
This is a mid-stage trial, so the cooling may not improve outcomes or could cause complications. The approach is still experimental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hypothermia ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE HYPOTHERMIA

Contacts and locations

Locations

  • 967 Hospital of the Joint Logistics Support Force of PLA

    Dalian, China

  • Affiliated Hospital of Inner Mongolia University for the Nationalities

    Tongliao, China

  • Beijing Chaoyang Hospital, Capital Medical University

    Beijing, China

  • Beijing Shijitan Hospital, Capital Medical University

    Beijing, China

  • Dalian Municipal Central Hospital

    Dalian, China

  • Department of Neurosurgery, Nanshi Hospital of Nanyang

    Nanyang, Henan, China

  • Gansu Province Central Hospital

    Gansu, China

  • Peking University Internation Hospital

    Beijing, China

  • The Affiliated Hospital of Xuzhou Medical University

    Xuzhou, Jiangsu, China

  • The First Affiliated Hospital of Harbin Medical University

    Ha’erbin, China

  • The Second Hospital and Clinical Medical School, Lanzhou University

    Lanzhou, Gansu, China

  • Zhejiang Provincial People's Hospital

    Hangzhou, China

More trials for these conditions

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