ACUTE ISCHEMIC STROKE

This early-stage study is testing the safety and early signs of effectiveness of a single intravenous infusion of donor-derived stem cells (called B2065) for people who have just had an ischemic stroke. The main goal is to see if the treatment is safe and well-tolerated when give…

This trial is testing if a common emergency clot-busting treatment for stroke is safe and effective for people who take a specific type of blood thinner (Factor Xa inhibitors). Currently, guidelines often prevent these patients from receiving this treatment due to bleeding concer…

This study is testing whether a procedure to remove a major blood clot from the brain can still help people who have had a stroke more than 24 hours ago. It will compare the procedure plus standard medical care against standard care alone in 382 carefully selected patients. The g…

This study is testing an investigational injection called KPCXM18 to see if it can help people recover better after an acute ischemic stroke. About 300 participants will receive either a low dose, a high dose, or a placebo injection for about 12 days. The main goal is to see if t…

This study is testing if giving a second blood-thinning drug called tirofiban soon after the standard clot-busting treatment (tenecteplase) is safe and helps people recover better from a stroke. It aims to prevent new clots from forming in the brain after the initial treatment. T…

This study is testing an investigational drug called sovateltide, given alongside standard care, to see if it can help people recover better after a sudden ischemic stroke. It aims to improve brain repair and help patients regain more function and independence. The trial will enr…

This large study is testing if adding a protein called albumin to the standard emergency procedure for removing a stroke-causing blood clot helps patients recover more function. It will involve about 1,200 adults who have just had a major stroke. The main goal is to see if more p…

This study is testing whether an experimental drug called MT200605 can help people recover better after a stroke. It aims to protect brain cells and reduce damage. The trial will enroll 360 stroke patients across China who will receive either the drug or a placebo along with stan…

This study is testing a new, thinner medical tube (catheter) designed to remove blood clots from the smaller, deeper vessels in the brain after a stroke. Doctors will use the device in up to 57 patients to see how well it restores blood flow and how safe it is. The goal is to imp…

This study is testing a new medical device called the RapidPulse Aspiration System for treating strokes caused by large blood clots in the brain. The device uses suction to remove the clot during a procedure that must be performed within 8 hours of stroke symptoms starting. Resea…

This study is testing whether a structured, 90-day home exercise program helps people recover better after a recent stroke. Researchers will compare the walking ability, daily function, and mood of 208 participants who either follow the guided exercise plan or just get general ad…

This study is testing if giving a powerful new cholesterol-lowering injection (evolocumab) along with standard statin pills within 48 hours of a stroke can prevent patients from getting worse and help them recover better. It will involve about 429 people who have had a stroke cau…

This study is testing if a new medicine called TBO-309 is safe to give alongside standard stroke treatments. It aims to help keep blood vessels open after a clot is removed, which could prevent the artery from blocking again. The study will enroll 80 people who have just had a st…

This trial is testing a new approach for a common type of stroke caused by blockages in medium-sized brain arteries. It will see if delivering a powerful clot-busting drug directly into the blocked artery, within 24 hours of stroke symptoms, helps people recover better than stand…

This study is testing whether a new injection called QHRD106 can help people recover better from a stroke caused by a blocked blood vessel in the brain. It is for patients who cannot receive the usual clot-busting treatment. About 320 participants will receive either the study dr…

This study is testing whether a new drug called JX10 can help people recover better from a stroke caused by a blocked brain artery, even if they arrive at the hospital 4.5 to 24 hours after symptoms start. Researchers will compare JX10 to a placebo (inactive substance) in about 7…

This study aims to find the safest and most effective dose of a clot-dissolving drug called urokinase for people having a stroke. Researchers will test different doses in 24 patients who arrive at the hospital within 6 hours of stroke symptoms starting. The main goal is to create…

This study is testing whether giving a clot-busting medication called Tenecteplase to stroke patients at their first hospital, before transferring them to a specialized center for advanced treatment, leads to better recovery. The trial involves 572 adults who have had a major str…

This study is testing if giving a clot-busting drug (tenecteplase) to stroke patients before they are transferred to a specialized hospital for a clot-removal procedure leads to better recovery. It focuses on patients with a severe type of stroke caused by a blockage in a major b…

This study is testing whether adding a second blood-thinning medication (clopidogrel) to standard aspirin treatment better prevents repeat strokes in the critical first 21 days after an initial stroke. Researchers will enroll 200 stroke patients who have received clot-busting tre…

This study is testing whether a minimally invasive procedure to remove blood clots is safe and effective for people having mild strokes caused by blockages in major brain arteries. Researchers will enroll 300 patients who have had stroke symptoms for less than 24 hours and compar…

This large, late-stage study is testing whether a new intravenous medicine called SHPL-49 can help people recover better after an acute ischemic stroke. About 1,100 participants who have recently had a stroke will receive either the study medicine or a placebo infusion for 7 days…

This study is testing whether two different versions of a traditional Chinese medicine pill work equally well for people who have just had a stroke. Researchers will follow 100 stroke patients for about three months to see which pill helps them recover better in terms of movement…

This study is testing whether a new drug called Aleeto can help people recover better after a moderate to severe stroke. Aleeto is made from stem cell particles and is given through an IV for about two weeks. Researchers will compare it to a placebo in 192 patients to see if it i…

This study is testing whether a clot-busting drug called tenecteplase can help stroke patients who arrive at the hospital more than 4.5 hours after symptoms begin. Researchers will give the drug to 890 Chinese stroke patients who are not eligible for standard clot-removal surgery…

This study is testing if adding a one-time dose of the drug tocilizumab to standard emergency surgery to remove a stroke-causing blood clot can help patients recover better. About 700 adults who have just had a major stroke will be randomly assigned to receive either the drug or …

This study aims to use artificial intelligence (AI) to create a personalized plan for stroke recovery. Researchers will gather detailed health data from 400 stroke survivors to train an AI system. The goal is for the AI to predict which type of rehabilitation therapy—like standar…

This study is testing a new medical device called Ceretrieve that is designed to quickly remove blood clots from the brain during a stroke. The goal is to see if the device is safe and works as well as other approved clot removal tools. Researchers will enroll 132 adults who are …

This study is testing if a procedure to physically reopen a blocked neck artery, combined with standard medication, leads to better recovery after a stroke than medication alone. It will involve 200 adults who have had a recent stroke caused by this specific type of blockage. The…

This study is testing a new medical device called the CONDA stent retriever that removes blood clots from brain arteries during a stroke. Researchers want to see if this device can safely and effectively restore blood flow to the brain in people experiencing acute ischemic stroke…

This large Phase 3 trial is testing whether a new clot-dissolving drug (rhTNK-tPA) can help people recover better from a major stroke, even if treatment starts up to 24 hours after symptoms begin. It will enroll about 890 adults who have a blocked brain artery and specific brain …

This study is testing if a clot-busting drug called tenecteplase can help people recover from a stroke even when given more than 4.5 hours after symptoms start. It includes adults who had a stroke or woke up with one, and brain scans show there is still tissue that might be saved…

This large study is testing if adding a steroid drug (methylprednisolone) directly into the artery and through an IV after a successful stroke clot removal procedure helps patients recover better. It will involve 1060 adults who have had a major stroke due to a large blocked arte…

This study is testing whether a specific approach to managing blood pressure after a stroke clot is removed helps people recover better. It will compare two strategies: one that slightly raises blood pressure and another that follows current standard guidelines. The goal is to se…

This large study is testing if a simple, non-invasive procedure called remote ischemic conditioning (RIC) can help people recover better after emergency surgery to remove a stroke-causing blood clot. RIC involves briefly inflating and deflating a blood pressure cuff on the arm. R…

This study is testing whether a specific method of controlling blood pressure is safer for patients receiving emergency clot-busting medication for a stroke. Researchers will compare a new, adjusted approach to the standard method, focusing on whether it reduces the risk of serio…

This study is testing if a clot-busting drug called tenecteplase is safe and helps people recover better after a stroke, specifically for patients who were recently taking common blood thinners (DOACs). About 912 participants will be randomly assigned to receive either the drug o…

This study is testing if adding a clot-busting drug directly into a blocked brain artery during a standard stroke surgery leads to better recovery. It will involve 530 stroke patients who have a blockage in a medium-sized brain artery. The main goal is to see if more patients can…

This study is testing whether a new injection called HRS-7450 can help people recover better after a recent ischemic stroke. It will involve 208 adults who had stroke symptoms start between 4.5 and 24 hours ago. Participants are randomly assigned to receive either the real inject…

This study is testing whether adding a medication called tirofiban after emergency clot removal (endovascular therapy) helps people recover better from a severe stroke. It will involve 716 patients who have had a stroke caused by a blocked brain artery. Half will receive tirofiba…

This early-stage study is testing whether tiny particles called exosomes, collected from human stem cells, can help the brain recover after a sudden stroke caused by a blocked blood vessel. Researchers will give these particles through an IV to a small group of patients to first …

This large study is testing whether customizing blood-thinner therapy based on how a patient's platelets respond can better prevent second strokes. It will enroll over 5,000 adults who recently had a minor stroke or warning sign. For patients whose bodies don't respond well to th…

This study is testing whether adding the drug tirofiban soon after standard clot-busting treatment helps people recover better from a stroke. It will involve over 1,000 adults who have just had a stroke and received the standard treatment. The goal is to see if this additional dr…

This study is testing whether an infusion of stem cells from donated umbilical cords can help people recover better after a recent stroke. It will involve 80 adults who had a moderate to severe stroke and are not eligible for standard clot-busting treatments. Participants will be…

This study is evaluating medical devices designed to quickly restore blood flow to the brain in people having a stroke. It will enroll 500 adults who have already received the device as their first treatment. The main goal is to collect real-world information on how well the devi…

This large study is testing if giving aspirin soon after a standard clot-busting treatment for stroke is safe and helps people recover better. It will involve over 1,100 stroke patients to see if this approach prevents the stroke from getting worse and improves long-term function…

This study aims to find the best way to treat severe strokes caused by blockages in both the neck and brain arteries. It will compare two approaches: the standard clot removal procedure versus adding a permanent stent to prop open the blocked neck artery during the same surgery. …

This study is testing a new drug called BB-031 for people who have just had a stroke caused by a blood clot. The main goals are to see if the drug is safe and how the body processes it. About 228 participants will receive either the study drug or a placebo and be monitored for 90…

This study is testing whether connecting local hospitals with stroke specialists via telemedicine improves treatment for stroke patients. It involves 2400 patients at basic-level hospitals across China. Half the hospitals will get remote guidance from expert stroke centers, while…

This study is testing whether a traditional Chinese herbal formula called Qingre Huatan can safely prevent patients' stroke symptoms from getting worse in the critical first week after a stroke. It will compare the herbal treatment to a placebo in 72 patients who have just had an…

This study is testing whether a minimally invasive procedure to remove blood clots from a specific brain artery improves recovery after certain types of stroke. Researchers will compare the clot-removal procedure against standard medical care in 200 adults who have had an acute i…

This study is testing if giving a blood-thinning medication (heparin) during a common imaging test for stroke can prevent a frequent complication where the wrist artery used for the test gets blocked. The trial will enroll 440 recent stroke patients to see if this approach is bot…

This trial is testing if adding a second drug called tirofiban helps people recover better after a stroke. It is for patients who receive the standard clot-busting medicine but don't show enough improvement within the first hour. About 976 participants will be randomly assigned t…

This study is testing if a non-invasive device that gently stimulates a nerve in the ear can help people recover from a major stroke. Researchers want to see if this stimulation can reduce harmful inflammation in the body and limit further brain injury after the initial stroke. T…

This study aims to find out which of two common sedation drugs works better for patients having emergency surgery to remove a stroke-causing blood clot. Researchers will compare midazolam and dexmedetomidine in 810 stroke patients to see which leads to better recovery and fewer d…

This study aims to understand why some stroke patients don't recover well even after successful clot removal. Researchers will compare special MRI brain scans with actual brain tissue samples from 15 patients who need major surgery after a severe stroke. The goal is to see if tin…

This worldwide registry study aims to understand a rare but serious complication that can occur during a common stroke treatment called thrombectomy, where a blood vessel tears. Researchers will collect data from 1,000 stroke patients to identify what makes this tear more likely …

This study is creating a collection of blood and tissue samples from people undergoing procedures for stroke or other blood vessel problems in the brain. Researchers will study these samples to find biological markers that could explain why strokes happen and how the body respond…

This study is collecting real-world information about how well medical devices work and how safe they are after they've been approved for treating brain aneurysms, strokes, and other blood vessel problems. It will follow up to 10,000 patients who have already received these devic…

This study is collecting real-world information on how well approved medical devices work for treating brain aneurysms and strokes. It will follow 1,000 patients who have already been treated with these devices as part of their standard care. The goal is to gather safety and effe…