ACUTE ISCHEMIC STROKE

This study tests whether a procedure to open a blocked carotid artery in the neck, plus standard medical care, helps people recover better from a stroke than standard care alone. About 200 adults with mild to severe stroke symptoms will be randomly assigned to one of two groups. …

This study tests whether removing a blood clot from the brain (endovascular thrombectomy) plus standard medical care can improve recovery in people who have a major stroke and arrive at the hospital 24 to 72 hours after symptoms began. About 408 adults aged 18-85 with severe stro…

This study tests whether adding a new anti-clotting drug called TBO-309 to standard stroke treatments is safe and tolerable. About 80 adults who have had an acute ischemic stroke will receive TBO-309 along with clot-dissolving drugs or mechanical clot removal. The main goal is to…

This study looks at whether slightly raising blood pressure after a stroke clot removal procedure helps patients recover better than the usual approach. About 176 adults who had a stroke and whose blood pressure stays low after the procedure will be randomly assigned to either a …

This study tests a new medicine called SHPL-49 given through a vein to people who have had a stroke caused by a blood clot. The goal is to see if it helps them recover better and have less disability 90 days later. About 1,096 adults aged 18-80 who are already getting standard cl…

This study tests a new device called the CONDA stent retriever in 50 people who have had a stroke caused by a large blood clot in the brain. The goal is to see if the device can safely reach and remove the clot to restore blood flow within 24 hours of symptoms starting. Participa…

This study tests a new treatment for people who have had a stroke caused by a blood clot. A weak electrical current is applied through electrodes on the scalp to increase blood flow to the brain and protect at-risk tissue. The goal is to find the safest and most effective dose. T…

This study tests a new drug called sovateltide for people who have had a stroke caused by a blood clot in the brain. The goal is to see if it helps patients recover better and have less disability. About 514 adults aged 18 to 80 will receive either the drug or a placebo, along wi…

This study tests an investigational drug called HRS-7450 in 208 adults who have had an acute ischemic stroke (a clot blocking blood flow to the brain). Participants must receive the drug or a placebo within 4.5 to 24 hours of their first symptoms. The main goal is to see if the d…

This study is for people having a severe stroke caused by a blockage in a major neck artery and a clot in the brain. It compares the usual clot-removal procedure with one that also places a stent in the neck artery. The goal is to see which approach leads to better recovery and l…

This study tests whether giving a second drug, tirofiban, soon after the standard clot-busting drug tenecteplase can improve outcomes for people with acute ischemic stroke. About 348 adults who had a stroke and received tenecteplase will be enrolled. The goal is to see if the com…

This study tests whether adding an anti-inflammatory drug (interleukin-6 receptor inhibitor) to the standard clot-removal procedure helps people recover better after a major stroke. About 692 adults with a large-vessel blockage in the front part of the brain will receive either t…

This study tests a special catheter (thin tube) designed to remove blood clots from small, hard-to-reach brain arteries in people having a stroke. About 57 adults who have had a stroke within the last 24 hours will receive the procedure. The goal is to see if the device can safel…

This study tests whether a clot-busting drug called tenecteplase can help people having a stroke who have recently taken blood thinners (DOACs). About 912 participants will receive either the drug or a placebo to see if it improves their recovery after 90 days. The goal is to fin…

This study looks at whether giving both clopidogrel and aspirin for 21 days after a stroke is safe and better than aspirin alone at preventing another stroke. About 200 adults who recently had a stroke and are at low bleeding risk will take part. The goal is to see if the two-dru…

This study tests whether giving the blood-thinner tirofiban soon after standard clot-busting therapy helps people recover better from a stroke. About 1,084 adults who had a moderate to severe stroke will receive either tirofiban or a placebo within 6 hours of their initial treatm…

This study tests an experimental drug called QHRD106 for people who have had an acute ischemic stroke. The goal is to see if it helps improve recovery and reduce disability. About 320 adults aged 18 to 80 who have not received standard clot-busting treatment will receive either t…

This study tests a new drug called BB-031 in people who have had a stroke caused by a blood clot. The goal is to see if the drug is safe and how the body handles it. About 228 participants will receive either the drug or a placebo within 24 hours of their stroke and be monitored …

This study tests whether giving a powerful cholesterol-lowering injection (evolocumab) together with standard statin pills within 48 hours of a stroke can prevent early brain damage. About 429 adults with moderate to severe artery narrowing in the brain will be randomly assigned …

This study tests whether removing a blood clot from the brain up to 72 hours after a major stroke can improve recovery. About 382 adults who had a large-vessel blockage stroke will be randomly assigned to either standard care or the clot-removal procedure. The goal is to see if t…

This study looks at whether giving the clot-busting drug Tenecteplase to stroke patients at a local hospital before transferring them to a specialized center can improve their recovery. About 572 adults with a severe type of stroke caused by a blocked artery in the brain will be …

This study tests whether telemedicine can help smaller hospitals with limited resources treat acute ischemic stroke more effectively. Researchers will compare outcomes for 2,400 patients who receive care with or without remote expert guidance. The goal is to see if telemedicine i…

This study tests an experimental drug called KPCXM18 in people who have had a stroke caused by a blood clot. The goal is to see if the drug helps patients recover better than a placebo. About 300 adults aged 18 to 80 will receive either the drug or a placebo within 12 hours of th…

This study tests a drug called rhTNK-tPA (Mingfule) to see if it can help people who have had a major stroke and can be treated between 4.5 and 24 hours after symptoms start. About 890 participants will receive either the drug or a placebo. The goal is to see if the drug improves…

This study tests a new drug called LT3001 for people who have had a stroke caused by a blood clot. The goal is to see if it helps patients recover better and with fewer side effects. About 300 adults aged 18 to 80 who can start treatment within 24 hours of their stroke will take …

This study tests a new device called the RapidPulse Aspiration System to remove blood clots from the brains of people having a severe stroke. About 170 adults aged 18 to 80 will be treated within 8 hours of their first symptoms. The goal is to see if the device can safely restore…

This study tests whether a minimally invasive procedure to remove blood clots from a medium-sized brain artery can help people recover better after a moderate-to-severe stroke. About 200 adults aged 18-84 who have had a stroke due to a blockage in the M2 segment of the middle cer…

This study looks at whether adding a drug called evolocumab (a PCSK9 inhibitor) to standard statin treatment helps people recover better after a stroke caused by hardening of the large arteries. About 1000 adults aged 18-80 who recently had a stroke will be enrolled. The goal is …

This study tests whether a noninvasive procedure called remote ischemic conditioning (using a blood pressure cuff on the arm) can help people recover better after a stroke caused by a large clot. About 2105 adults who have had a stroke and are getting a clot-removal procedure wil…

This study is testing a medical device designed to quickly restore blood flow in people having a severe stroke caused by a blocked artery. About 500 participants will receive the device as their first treatment. The goal is to see how well it reopens the artery and improves recov…

This study tests whether adding a clot-dissolving medicine directly into the brain artery improves recovery for people having a stroke from a medium-sized vessel blockage. About 530 adults who can be treated within 24 hours of symptoms will be randomly assigned to get either stan…

This study looks at whether adjusting blood pressure differently during clot-busting treatment for stroke can lower the risk of dangerous bleeding in the brain. About 340 adults aged 18 to 80 with acute ischemic stroke and high blood pressure will take part. Researchers will comp…

This study tests whether using a platelet function blood test to choose anti-clotting medication can reduce the risk of another stroke in people who recently had a mild stroke or high-risk TIA. About 5,138 participants will either receive standard care or have their medication sw…

This study tests whether giving the blood thinner tirofiban right after a clot-removal procedure helps people recover better from a severe stroke caused by hardened arteries. About 716 adults who have had a major stroke will be randomly assigned to receive either tirofiban or a p…

This study tests whether a single infusion of stem cells from donated umbilical cord blood can help people recover function after a moderate to severe stroke. The trial enrolls 80 adults who had a stroke within the past 4 weeks and cannot receive standard clot-busting drugs or su…

This study looks at how safe and effective the EmboTrap II device is at removing blood clots in people having a severe stroke. About 100 participants will be watched to see if the device can restore blood flow to the brain without causing harm. The goal is to improve recovery by …

This study compares a procedure to remove blood clots from the brain (endovascular therapy) with standard medical treatment for people who have had a mild stroke caused by a blockage in a large artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within …

This study tests whether adding a drug called tirofiban after standard clot-busting treatment helps people who had a stroke and aren't improving enough. About 976 adults will receive either tirofiban or a placebo for 24 hours, then standard care. The goal is to see if more people…

This study looks at whether giving a clot-dissolving drug called tenecteplase before transferring patients with a severe type of stroke (basilar artery occlusion) to a hospital that can perform clot removal improves recovery. The trial involves 316 adults who had a stroke 4.5 to …

This study tests whether exosomes (tiny particles) from stem cells can help people recover from a recent stroke. About 29 adults aged 18-70 with moderate to severe stroke will receive either the exosomes or a placebo through an IV. The goal is to see if the treatment is safe and …

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 1,060 adults who had a large-vessel stroke will receive either the steroid or a placebo through an artery and then through a vein ove…

This study tests a new tool called the Ceretrieve device, designed to remove blood clots from brain arteries in people having a severe stroke. About 132 participants will be treated within 24 hours of their first symptoms. Researchers will check if the device safely restores bloo…

This study tests whether a gentle nerve stimulation (applied to the ear) can reduce brain injury and inflammation after a stroke caused by a large blood clot. About 65 adults will either receive standard care or standard care plus the stimulation. Researchers will measure brain d…

This study tests whether giving albumin, a protein found in blood, along with standard clot-removal treatment helps people recover better from a severe stroke. About 1,200 adults aged 18-80 with a large-vessel stroke in the front part of the brain will be enrolled. The main goal …

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. About 54 adults aged 18-75 with moderate-to-severe stroke will receive either the stem cells or a placebo. The main goals are to check safety and see if the treatment helps improve recove…

This study tests a new drug called MT200605 in people who have had an acute ischemic stroke within the past 24 hours. The drug aims to protect brain cells and reduce damage from the stroke. About 360 participants will receive either a high, medium, or low dose of the drug or a pl…

This study is testing a device called the NeVa stent-retriever to see how well it can remove blood clots in people having a severe stroke. The goal is to restore blood flow to the brain in a single pass of the device. The study will enroll 600 adults who are already scheduled for…

This study tests a new drug, Aleeto, to see if it helps people recover better after a moderate to severe stroke. About 192 adults who have had a stroke within the last 72 hours will receive either Aleeto or a placebo. The main goal is to measure changes in stroke-related disabili…

This study tests a new medicine called TAK-755 in adults who have had a stroke caused by a blood clot. The goal is to see if it is safe and helps people recover better than standard care alone. About 222 participants will receive either TAK-755 or a placebo once, and their health…

This study compares two versions of Angong Niuhuang Pills, a traditional Chinese medicine, in 100 adults who recently had an acute ischemic stroke. Participants will take the pills or receive standard care, and researchers will track recovery, brain imaging, and blood markers ove…

This study tests whether a procedure to reopen a blocked artery in the back of the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 adults will be randomly assigned to get either the procedure or standard medical care. The goal is to see if more peo…

This study tests a drug called tenecteplase (TNK) given directly to the brain through a tiny tube to treat strokes caused by medium-sized blood vessel blockages. About 382 adults who have had a stroke within the last 24 hours will receive either standard care or this targeted dru…

This study tests whether stroke patients who take blood thinners (FXa inhibitors) can safely receive a standard clot-busting drug (IVT). Current guidelines deny IVT to these patients due to bleeding fears, but new evidence suggests it may be safe. The trial will compare recovery …

This study tests a drug called tenecteplase in people who have had a stroke and can only be treated more than 4.5 hours after symptoms started. The goal is to see if the drug can help them recover with little or no disability. About 890 participants will receive either the drug o…

This study looks at whether giving aspirin soon after clot-busting medication for ischemic stroke can help patients recover better without causing dangerous bleeding. About 1,184 adults who had a stroke and still have symptoms after clot-busting drugs will receive either aspirin …

This study is testing whether an experimental drug called JX10 can help people recover better from a stroke caused by a blocked blood vessel in the brain. It focuses on patients who arrive at the hospital between 4.5 and 24 hours after their stroke symptoms begin, which is later …

This study tests whether a traditional Chinese herbal formula, Qingre Huatan, can prevent early neurological worsening in people who have had an acute ischemic stroke. About 72 participants will receive either the herbal formula or a placebo within 48 hours of their stroke. The m…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This study aims to find the safest and most effective dose of urokinase, a clot-busting drug, for people having an acute ischemic stroke. Researchers will enroll 24 adults aged 18-80 who can receive treatment within 6 hours of symptoms starting. The goal is to develop a weight-ba…

This study compares two types of conscious sedation used during emergency clot removal in people having a major stroke. The goal is to see which method helps patients recover better and have fewer complications. About 810 adults with a blocked artery in the front part of the brai…

This study tests whether tilting the head down 15° during a stroke, just before a procedure to remove a blood clot, can improve blood flow to the brain and lead to better outcomes. About 118 adults having a stroke due to a blocked artery will be randomly assigned to either head-d…

This study tests whether the clot-busting drug tenecteplase can help people who had a stroke more than 4.5 hours ago or woke up with stroke symptoms. About 1,325 adults with brain scans showing salvageable tissue will receive either tenecteplase or standard care. The goal is to s…

This study aims to build an AI system that predicts the best rehabilitation approach for each stroke survivor. Researchers will collect data from 400 participants aged 65-80 who had a stroke 1-6 months ago and have moderate-to-severe arm weakness. The AI will analyze brain scans,…

This study looks at whether measuring how well the brain controls its own blood flow during a stroke procedure can help doctors know early if the treatment will lead to a good recovery. About 129 adults with severe strokes will be monitored during a clot-removal procedure and fol…

This study compares two ways to reach and remove a blood clot in a major artery at the back of the brain during a severe stroke. One method goes through an artery in the wrist, the other through the groin. About 386 adults with this type of stroke will be randomly assigned to one…

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in everyday medical practice. No new treatments are being tested—just real-world data is gather…

This study aims to find new biomarkers in blood and saliva that can quickly and accurately tell if someone is having a stroke. Researchers will study 650 adults with suspected stroke to improve early detection and diagnosis. The goal is to develop better tools to differentiate st…

This study looks at why some stroke patients don't fully recover even after main artery blockage is removed. Researchers will compare MRI scans with brain tissue samples from 15 patients who need surgery for severe stroke. The goal is to see if certain MRI signals indicate tiny c…

This study aims to understand how a stroke can disrupt the body's automatic functions like heart rate and blood pressure. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart monitoring. The goal is to find better ways to…

This study collects blood, clots, and tissue from up to 1000 people having stroke-related procedures. Researchers will analyze these samples to find biological markers and understand what happens in the body during a stroke. The goal is to improve future treatments and make them …

This worldwide study looks at a rare but serious complication—a blood vessel tear—that can happen during a stroke treatment called thrombectomy. Researchers will study 1000 patients to understand what causes the tear, how to classify it, and how to stop bleeding quickly. The goal…

This study is not testing a new treatment but gathering information on how well BALT medical devices work in real-world use for conditions like brain aneurysms, stroke, and vascular diseases. Up to 10,000 participants will be followed to track device safety, performance, and ease…

This study looks at 100 people who recently had a stroke and need surgery to open a blocked neck artery. Half will get numbing medicine only in the neck (regional anesthesia), and the other half will be fully asleep (general anesthesia). The goal is to see which method leads to f…