New stroke drug shows promise in major trial

NCT ID NCT05691244

Recruiting now Disease control Sponsor: Pharmazz, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achieve a good functional outcome (score 0-2 on the modified Rankin Scale) 90 days after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sovateltide (also called PMZ-1620)
What this could lead to: If successful, sovateltide could become a new treatment to help people recover better after a stroke, reducing long-term disability.
What could go wrong: This is a Phase 3 trial, but earlier studies were small and mostly in India. The drug may not work as well in a larger, more diverse group, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral infarction ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE CEREBRAL STROKE

Contacts and locations

Locations

CHI Memorial Neuroscience Institute
RECRUITING

Chattanooga, Tennessee, 37404, United States
Charite-Universitaetsmedizin Berlin
RECRUITING

Berlin, State of Berlin, 12203, Germany
Complejo Hospitalario Universitario de Albacete
RECRUITING

Albacete, Castille-La Mancha, 2006, Spain
Fairfield General Hospital
RECRUITING

Bury, Bury, BL9 7TD, United Kingdom
Guilford Neurologic Associates Inc
RECRUITING

Greensboro, North Carolina, 27401, United States
Hackensack University Medical Center at Paramus
RECRUITING

Paramus, New Jersey, 07652, United States
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clinico Universitario de Santiago
RECRUITING

Santiago, 15706, Spain
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Clínico Universitario Virgen de Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
Hospital Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 08916, Spain
Hospital Universitari Joan XXIII
RECRUITING

Tarragona, Tarragona, 43005, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe de Valencia
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Infanta Cristina (HUB)
RECRUITING

Badajoz, 06080, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Madrid, 28046, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Madrid, Madrid, 28222, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Sevilla, 41009, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Cruces
RECRUITING

Barakaldo, 48903, Spain
Hospitals NHS Foundation Trust - Royal Victoria Infirmary RVI
RECRUITING

Newcastle, NE1 4LP, United Kingdom
Houston Medical Neurological Institute
RECRUITING

Houston, Texas, 77030, United States
Institut Catala d'Oncologia (ICO) - Hospital Universitari Doctor Josep Trueta
RECRUITING

Girona, 17007, Spain
Instituto de Investigación Biomédica de A Coruña
RECRUITING

A Coruña, 15006, Spain
King's College Hospital NHS Foundation Trust
RECRUITING

London, London, SE5 9RS, United Kingdom
Klinik fuer Neurologie, Stroke Unit und Fruehrehabilitation Dorstener Strae 151
RECRUITING

Recklinghausen, Recklinghausen, 45657, Germany
Klinikum Altenburger Land GmbH
RECRUITING

Altenburg, Altenburg, 04600, Germany
Klinikum der Stadt Ludwigshafen gGmbh
RECRUITING

Rhein, Ludwigshafen Am, 67063, Germany
London North West University Healthcare NHS Trust - Northwick Park Hospital
RECRUITING

Harrow, HA1 3UJ, United Kingdom
Medical Imbrain S.L.
RECRUITING

Melilla, 52001, Spain
Memorial Hermann Hospital
RECRUITING

Houston, Texas, 77030, United States
Mercy Medical Group
RECRUITING

Carmichael, California, 95608, United States
Muhlenkreiskliniken (MKK) - Johannes Wesling Klinikum Minden - Neurologische Klinik
RECRUITING

Minden, North Rhine-Westphalia, 32427, Germany
National Hospital for Neurology & Neurosurgery
RECRUITING

London, London, NW1 2BU, United Kingdom
New Cross Hospital - Royal Wolverhampton NHS Trust
RECRUITING

Wolverhampton, Wolverhampton, WV10 0QP, United Kingdom
OSU Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Penn State Health Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
RHON-KLINIKUM Campus Bad Neustadt
RECRUITING

Bad Neustadt an der Saale, 97616, Germany
Royal Stoke University Hospital
RECRUITING

Stoke-on-Trent, ST4 6QG, United Kingdom
SSM Health Neurosciences
RECRUITING

Bridgeton, Missouri, 63044, United States
Sarasota Memorial Hospital
RECRUITING

Sarasota, Florida, 34239, United States
St. George's University Hospitals
RECRUITING

London, London, SW17 0QT, United Kingdom
St. John's Regional Medical Center
RECRUITING

Oxnard, California, 93030, United States
The University of Arizona - College of Medicine
RECRUITING

Tucson, Arizona, 85719, United States
UPMC Presbyterian Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Goettingen
RECRUITING

Göttingen, Lower Saxony, 37075, Germany
University Hospital Southampton
RECRUITING

Southampton, Southampton, SO16 6YD, United Kingdom
University Hospital Tuebingen
RECRUITING

Tübingen, Germany
Universitätsklinikum Essen AöR
RECRUITING

Essen, 45147, Germany
Universitätsklinikum Schleswig-Holstein AöR
RECRUITING

Lübeck, 23538, Germany
Wellstar Kennestone Hospital
RECRUITING

Marietta, Georgia, 30060, United States

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