New stroke drug shows promise in major trial

NCT ID NCT05691244

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achieve a good functional outcome (score 0-2 on the modified Rankin Scale) 90 days after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

sovateltide (also called PMZ-1620)

What this could lead to

If successful, sovateltide could become a new treatment to help people recover better after a stroke, reducing long-term disability.

What could go wrong

This is a Phase 3 trial, but earlier studies were small and mostly in India. The drug may not work as well in a larger, more diverse group, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cerebral infarction ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHI Memorial Neuroscience Institute

    RECRUITING

    Chattanooga, Tennessee, 37404, United States

    Contact

  • Charite-Universitaetsmedizin Berlin

    RECRUITING

    Berlin, State of Berlin, 12203, Germany

    Contact Email: •••••@•••••

  • Complejo Hospitalario Universitario de Albacete

    RECRUITING

    Albacete, Castille-La Mancha, 2006, Spain

    Contact

  • Fairfield General Hospital

    RECRUITING

    Bury, Bury, BL9 7TD, United Kingdom

    Contact

  • Guilford Neurologic Associates Inc

    RECRUITING

    Greensboro, North Carolina, 27401, United States

    Contact

  • Hackensack University Medical Center at Paramus

    RECRUITING

    Paramus, New Jersey, 07652, United States

    Contact Email: •••••@•••••

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, 28040, Spain

    Contact

  • Hospital Clinico Universitario de Santiago

    RECRUITING

    Santiago, 15706, Spain

    Contact

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

    Contact

  • Hospital Clínico Universitario Virgen de Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

    Contact

  • Hospital Germans Trias i Pujol

    RECRUITING

    Badalona, Barcelona, 08916, Spain

    Contact

  • Hospital Universitari Joan XXIII

    RECRUITING

    Tarragona, Tarragona, 43005, Spain

    Contact

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, Barcelona, 08035, Spain

    Contact

  • Hospital Universitari i Politecnic La Fe de Valencia

    RECRUITING

    Valencia, 46026, Spain

    Contact

  • Hospital Universitario Infanta Cristina (HUB)

    RECRUITING

    Badajoz, 06080, Spain

    Contact

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Madrid, 28046, Spain

    Contact

  • Hospital Universitario Miguel Servet

    RECRUITING

    Zaragoza, 50009, Spain

    Contact

  • Hospital Universitario Puerta de Hierro Majadahonda

    RECRUITING

    Madrid, Madrid, 28222, Spain

    Contact

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

    Contact

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, Sevilla, 41009, Spain

    Contact

  • Hospital Universitario Virgen del Rocio

    RECRUITING

    Seville, 41013, Spain

    Contact

  • Hospital Universitario de Cruces

    RECRUITING

    Barakaldo, 48903, Spain

    Contact

  • Hospitals NHS Foundation Trust - Royal Victoria Infirmary RVI

    RECRUITING

    Newcastle, NE1 4LP, United Kingdom

    Contact

  • Houston Medical Neurological Institute

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

  • Institut Catala d'Oncologia (ICO) - Hospital Universitari Doctor Josep Trueta

    RECRUITING

    Girona, 17007, Spain

    Contact

  • Instituto de Investigación Biomédica de A Coruña

    RECRUITING

    A Coruña, 15006, Spain

    Contact

  • King's College Hospital NHS Foundation Trust

    RECRUITING

    London, London, SE5 9RS, United Kingdom

    Contact

  • Klinik fuer Neurologie, Stroke Unit und Fruehrehabilitation Dorstener Strae 151

    RECRUITING

    Recklinghausen, Recklinghausen, 45657, Germany

    Contact

  • Klinikum Altenburger Land GmbH

    RECRUITING

    Altenburg, Altenburg, 04600, Germany

    Contact

  • Klinikum der Stadt Ludwigshafen gGmbh

    RECRUITING

    Rhein, Ludwigshafen Am, 67063, Germany

    Contact

  • London North West University Healthcare NHS Trust - Northwick Park Hospital

    RECRUITING

    Harrow, HA1 3UJ, United Kingdom

    Contact Email: •••••@•••••

  • Medical Imbrain S.L.

    RECRUITING

    Melilla, 52001, Spain

    Contact Email: •••••@•••••

  • Memorial Hermann Hospital

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

  • Mercy Medical Group

    RECRUITING

    Carmichael, California, 95608, United States

    Contact

  • Muhlenkreiskliniken (MKK) - Johannes Wesling Klinikum Minden - Neurologische Klinik

    RECRUITING

    Minden, North Rhine-Westphalia, 32427, Germany

    Contact

  • National Hospital for Neurology & Neurosurgery

    RECRUITING

    London, London, NW1 2BU, United Kingdom

    Contact

  • New Cross Hospital - Royal Wolverhampton NHS Trust

    RECRUITING

    Wolverhampton, Wolverhampton, WV10 0QP, United Kingdom

    Contact

  • OSU Wexner Medical Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact

  • Penn State Health Milton S. Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

    Contact Email: •••••@•••••

  • RHON-KLINIKUM Campus Bad Neustadt

    RECRUITING

    Bad Neustadt an der Saale, 97616, Germany

    Contact Email: •••••@•••••

  • Royal Stoke University Hospital

    RECRUITING

    Stoke-on-Trent, ST4 6QG, United Kingdom

    Contact Email: •••••@•••••

  • SSM Health Neurosciences

    RECRUITING

    Bridgeton, Missouri, 63044, United States

    Contact

  • Sarasota Memorial Hospital

    RECRUITING

    Sarasota, Florida, 34239, United States

    Contact

  • St. George's University Hospitals

    RECRUITING

    London, London, SW17 0QT, United Kingdom

    Contact Email: •••••@•••••

  • St. John's Regional Medical Center

    RECRUITING

    Oxnard, California, 93030, United States

    Contact

  • The University of Arizona - College of Medicine

    RECRUITING

    Tucson, Arizona, 85719, United States

    Contact Email: •••••@•••••

  • UPMC Presbyterian Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

    Contact

  • Universitaetsklinikum Erlangen

    RECRUITING

    Erlangen, 91054, Germany

    Contact Email: •••••@•••••

  • Universitaetsklinikum Goettingen

    RECRUITING

    Göttingen, Lower Saxony, 37075, Germany

    Contact

  • University Hospital Southampton

    RECRUITING

    Southampton, Southampton, SO16 6YD, United Kingdom

    Contact

  • University Hospital Tuebingen

    RECRUITING

    Tübingen, Germany

    Contact Email: •••••@•••••

  • Universitätsklinikum Essen AöR

    RECRUITING

    Essen, 45147, Germany

    Contact

  • Universitätsklinikum Schleswig-Holstein AöR

    RECRUITING

    Lübeck, 23538, Germany

    Contact

  • Wellstar Kennestone Hospital

    RECRUITING

    Marietta, Georgia, 30060, United States

    Contact