ACUTE ISCHEMIC STROKE

This study tested whether adding the drug tirofiban after a mechanical clot removal procedure improves recovery in people with a severe type of stroke caused by a large blockage. About 1,380 adults who had a stroke within the last 24 hours took part. The goal was to see if tirofi…

This early-stage study tested the safety of an experimental drug called PP-007 in 24 people having an acute ischemic stroke (a stroke caused by a blood clot). Participants received two doses of the drug along with standard treatments like clot-busting medicine or clot removal. Th…

This study tested a clot-dissolving drug called rhTNK-tPA in 570 adults who had a stroke but no blockage in a major brain artery. Participants received the drug between 4.5 and 24 hours after their symptoms began. The goal was to see if the drug helped them recover with little or…

This study tested whether a mild electrical stimulation of a nerve in the ear (called taVNS) could reduce inflammation and improve recovery in 40 adults who had a severe ischemic stroke. Participants received either standard care or standard care plus the ear stimulation. The mai…

This early study tested a new device that cools the brain after a stroke clot is removed. Eight adults with acute ischemic stroke received 30 minutes of targeted brain cooling right after their clot removal procedure. The goal was to see if the device is safe and works as intende…

This study tested a new drug called LT3001 in 89 people who had an acute ischemic stroke (a stroke caused by a blood clot). The goal was to see if the drug is safe and if it helps patients recover. Participants received either the drug or a placebo within 24 hours of their stroke…

This study tested a new tool called the Millipede System to remove large blood clots from the brains of people having a severe stroke. The goal was to see if the device could safely restore blood flow. The study included 246 adults aged 18 to 85 with disabling stroke symptoms.

This study tested an experimental drug called elezanumab in 121 people who had a recent stroke. The goal was to see if the drug could help improve brain function and recovery compared to a placebo. Participants received the drug or placebo by IV within 24 hours of the stroke and …

This study tested a new medicine called SHPL-49 given as an IV for 7 days to people who had a stroke caused by a blood clot. The goal was to see if it helps them recover better and is safe. 270 adults aged 18-80 took part in this Phase 2 trial.

This study tested two blood thinners, tirofiban and aspirin, in 240 stroke patients who also had a blocked or narrowed neck artery. The goal was to see which drug better prevents the artery from re-blocking after a procedure to open it, while also checking for bleeding risks. Res…

This study looked at 345 people with a severe type of stroke caused by a blockage in the main artery at the back of the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to see …

This study tested a new drug called LT3001 in 24 people who had an acute ischemic stroke (a stroke caused by a blood clot). The goal was to see if a single dose of the drug is safe and might help recovery. Participants received either the drug or a placebo within 24 hours of thei…

This study tested whether trimetazidine, a drug used for heart conditions, can improve recovery in people who had an acute ischemic stroke. Researchers measured inflammation levels and disability scores in 60 adult patients. The goal was to see if the drug reduces brain damage an…

This study tested whether giving a blood thinner (heparin) during a brain scan through the wrist can prevent the wrist artery from closing up afterward. It involved 440 adults who had a recent stroke and needed this scan. The goal was to see if heparin is both effective and safe,…

This study tested a clot-busting drug called non-immunogenic staphylokinase in over 23,000 adults who had an acute ischemic stroke. The goal was to see how safe and effective the drug is in everyday hospital settings. Patients received the drug within 4.5 hours of symptoms starti…

This early-stage study tested a new drug called HRS-7450 in 64 adults who had an acute ischemic stroke (a stroke caused by a blood clot). The main goal was to see if the drug is safe and tolerable, especially regarding the risk of bleeding in the brain. Researchers also looked at…

This study looked at whether giving the drug butylphthalide earlier (within 3 hours) or later (3-6 hours) after a stroke helps patients recover better. About 200 adults aged 18-80 with acute ischemic stroke took part. The goal was to find the best time to start treatment to impro…

This study tested a drug called conestat alfa (Ruconest) to see if it could prevent strokes and kidney damage in people getting a new heart valve without open-heart surgery (TAVI). About 141 patients with severe aortic stenosis took part. The drug aims to reduce brain lesions and…

This study tested whether kinesio taping (a special elastic tape placed on the skin) can improve arm and hand movement, reduce pain, and boost mood in people who recently had a stroke. 26 adults with arm weakness were randomly assigned to receive either real kinesio taping or a f…

This study tested a drug called sodium sivelestat in 20 people who had a stroke caused by a large blood clot in the brain. All participants had the clot removed with a procedure called mechanical thrombectomy. The drug aims to reduce inflammation and improve recovery. The main go…

This study looked at 34 adults with acute ischemic stroke and very high blood pressure who needed treatment to restore blood flow. Researchers compared two drugs, nicardipine and labetalol, to see which one lowered blood pressure to a safe level faster. The goal was to help docto…

This study tested whether giving N-Acetylcysteine (NAC) through an IV can help people who have had a stroke. NAC is an antioxidant and anti-inflammatory drug already used safely for other conditions. The trial enrolled 4 adults with acute ischemic stroke to see if it improves bra…

This study tested whether raising the legs (elevated leg positioning) is safe and doable for people who had a moderate ischemic stroke within the past 24 hours. Fifty adults took part, and researchers checked how well they followed the leg-raising plan and watched for any side ef…

This early-stage study tested the safety of a new drug called LT3001, which is being developed for acute ischemic stroke. It involved 65 healthy adults to see how the drug behaves in the body and whether it interacts safely with common medications like aspirin and blood thinners.…

This study looked at 400 people with severe stroke who had a large area of brain damage. All had a procedure to remove a blood clot within 24 hours of symptoms starting. Researchers wanted to find out which factors helped these patients walk independently or survive. The goal is …

This study looked at whether using a balloon-guided catheter is better than a standard one for treating acute ischemic stroke. About 110 adults with stroke in the front part of the brain took part. Researchers measured how well blood flow was restored and checked patients' qualit…

This study aimed to find better ways to predict serious problems that can happen after a stroke, like brain swelling or bleeding. Researchers looked at brain scans and blood tests from 213 people who had a stroke. They also studied mice to understand how brain cells change after …

This study tested a new web-based tool designed to help families of patients with severe brain injuries (like stroke or traumatic brain injury) communicate with doctors and make decisions about care goals. The study enrolled 50 family decision-makers to see if the tool was easy t…

This study tested a new technique called rapid local ischemic postconditioning in 25 people who had a stroke and received successful clot removal. The technique temporarily stops and restarts blood flow to the brain to help it adapt and reduce damage. The main goal was to check s…

This study checked how well and how safely a new medical wire, called the Tarvos Microguidewire, works during brain surgeries for conditions like aneurysms and stroke. Researchers looked back at records from 121 patients who had this wire used in their procedure. The main goal wa…

This study looked at 174 adults who had a major stroke and were treated under general anesthesia. Researchers compared removing the breathing tube early versus later to see which approach leads to better recovery and independence three months later. The goal is to find the best t…

This study tested whether an artificial intelligence (AI) tool helps doctors and radiographers read head CT scans more accurately and quickly. 33 readers reviewed 150 scans, some normal and some showing brain injuries like bleeding or stroke. The goal was to see if AI assistance …

This study looked at 481 adults who had a stroke and underwent a procedure to remove a blood clot. Researchers compared those who received general anesthesia (fully asleep) versus sedoanalgesia (awake but relaxed) to see if one led to better survival and brain recovery. The goal …