ACUTE ISCHEMIC STROKE

This study tests a device called the Penumbra System with Thunderbolt Aspiration Tubing to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. The goal is to see if the device can safely and effectively restore blood flow within 8 hou…

This study tests whether a smart bracelet system can help hospitals treat stroke patients faster. The bracelets track where patients are in the emergency room and send alerts if treatment is delayed. The goal is to shorten the time between arrival and life-saving clot-busting the…

This phase 2 trial tested a new gel called OTR4132 in 60 people who had a stroke and received a clot-removal procedure. The gel is designed to help repair damaged brain tissue. Researchers measured neurological function at 24 hours and disability at 3 months to see if the gel imp…

This study tested a soft robotic sock called VACOM in 19 stroke patients who had trouble moving their ankle. The sock gently moves the ankle to prevent stiffness and improve blood flow, aiming to reduce the risk of blood clots and contractures. The trial is complete, but results …

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke could prevent early neurological decline. It included 429 adults with moderate to severe narrowing of brain arteries. The goal was to see if …

This study looked at whether a procedure to remove a blood clot from the brain (endovascular therapy) works better than medication alone for people with mild stroke symptoms and a visible clot. About 4,800 adults with mild stroke were included. The goal was to see which approach …

This study tested two blood thinners—tirofiban and aspirin—in 240 stroke patients who also had a severe blockage in the neck artery. The goal was to see which drug better prevents the artery from reclosing after emergency surgery, while also checking for bleeding risks. Results w…

This study tested a new medical wire, called the Tarvos Microguidewire, used during surgery on blood vessels in the brain. The wire helps doctors guide other tools to the right spot. Researchers looked back at records of 121 patients who had this wire used in their surgery for co…

This study tested whether giving heparin (a blood thinner) during brain angiography can prevent the radial artery in the wrist from becoming blocked afterward. The trial involved 440 acute stroke patients and compared heparin to a placebo. The goal was to see if heparin reduces a…

This study tested whether adding sodium sivelestat, a drug that reduces inflammation, to standard mechanical thrombectomy could improve outcomes in 20 stroke patients with large vessel occlusion. The drug aims to prevent 'futile recanalization,' where blood flow is restored but p…

This early study tested a new device that cools the brain in 8 people who had a stroke caused by a large blood clot. After doctors removed the clot, the device cooled the brain for 30 minutes to try to protect it from further damage. The main goal was to see if the cooling was sa…

This study tested whether using a balloon-guided catheter helps doctors remove blood clots more effectively in people having a stroke. 110 adults with acute ischemic stroke were randomly assigned to receive clot removal with either a balloon-guided or standard catheter. The main …

This study tested whether giving the blood-thinning drug tirofiban after mechanical clot removal improves outcomes for people with severe stroke. Over 1,300 participants were randomly assigned to receive tirofiban or a placebo. The goal was to see if more patients could live inde…

This study tested a new device called the Millipede System in 246 stroke patients with large blood clots in the brain. The device is designed to remove clots and restore blood flow. Researchers measured how often blood flow was successfully restored and tracked any side effects. …

This study tested whether giving N-Acetylcysteine (NAC) intravenously soon after an acute ischemic stroke could improve outcomes. Only 4 adults with moderate to severe stroke were enrolled. Researchers measured stroke severity and disability at 30 and 90 days. The trial is comple…

This Phase IIa trial tested a single dose of LT3001, a new drug, in 24 people who had an acute ischemic stroke within the past 24 hours. The main goal was to see if the drug causes dangerous bleeding in the brain compared to a placebo. Researchers also looked for early signs that…

This study compares two ways to remove large blood clots from the brain during a stroke: direct aspiration (ADAPT) and using a stent retriever. About 381 adults with stroke caused by a blocked artery in the front part of the brain took part. The goal is to see which method clears…

This study tested a clot-dissolving medicine called alteplase in 58 people who had a stroke caused by a blocked artery. The goal was to see how well it reopened blocked brain arteries and improved patients' ability to function three months later. The results were compared to exis…

This study tested a lower dose (0.6 mg/kg) of the clot-busting drug alteplase in 103 Japanese patients who had a stroke within the previous 3 hours. The goal was to see if this dose was both safe and effective for this population. Results focused on how many patients had little t…

This study compared two medications, edaravone and sodium ozagrel, for treating acute ischemic stroke. Researchers wanted to see which drug helped more people recover with little or no disability three months after treatment. The study included 401 adults who started treatment wi…

This Phase 2 trial tested a drug called LT3001 in 89 people who had an acute ischemic stroke. Participants received either the drug or a placebo within 24 hours of their stroke. The study found no serious drug-related side effects, suggesting LT3001 is safe. Researchers are now l…

This Phase 2 trial tested an experimental drug called elezanumab in 121 people who had an acute ischemic stroke. The goal was to see if it could safely improve neurological function and reduce disability compared to a placebo. Participants received the drug or placebo by IV withi…

This study tested a technique called ischemic postconditioning in 60 stroke patients who already had a procedure to remove a clot. After the clot was removed, doctors briefly stopped and restarted blood flow in the affected artery four times. The goal was to see if this extra ste…

This study tested a clot-dissolving drug called non-immunogenic staphylokinase in over 23,000 adults who had an acute ischemic stroke within the last 4.5 hours. The goal was to see how safe and effective the drug is in everyday hospital practice. Researchers measured how many pat…

This study tested whether a clot-busting drug called rhTNK-tPA can help people having a stroke when given 4.5 to 24 hours after symptoms begin. It included 570 adults with a stroke that did not involve a large blocked artery. The goal was to see if the drug leads to better recove…

This study looked at 260 people having emergency stroke treatment to remove a clot. Some were given sedation (awake but relaxed) and others were put under general anesthesia (completely asleep). The goal was to see which approach leads to better recovery and fewer complications a…

This study tested a procedure called rapid local ischemic postconditioning in 25 people who had a stroke and successful clot removal. Right after reopening the blocked artery, doctors briefly inflated and deflated a balloon in the neck to temporarily stop blood flow, aiming to he…

This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to…

This early-stage study tested a drug called PP-007 in 24 people having an acute ischemic stroke. The drug is designed to carry oxygen to the brain. Researchers checked if adding it to standard treatments like clot-busting drugs or clot removal was safe. The goal was to see how th…

This study tested a new drug called SHPL-49 in 270 people who had an acute ischemic stroke. Participants received either the drug or a placebo as an IV infusion twice daily for 7 days. The goal was to see if the drug helps improve recovery and is safe to use.

This study tested a new medicine called HRS-7450 in 64 adults who had a stroke within the past 4.5 to 24 hours. The goal was to check if the drug is safe and might help restore blood flow to the brain. Researchers monitored for bleeding and other side effects to see if the treatm…

This study tested whether trimetazidine, a drug usually used for heart conditions, can improve outcomes in people who had an acute ischemic stroke. 60 adults were enrolled within 6-12 hours of their stroke. Researchers measured inflammation levels, stroke severity, and disability…

This study looked at whether measuring two proteins in the blood (GST-π and PRDX1) can accurately determine if a stroke occurred within the last 4.5 hours. That time window is critical because it determines if patients can receive clot-busting medication. Researchers enrolled 935…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study looked at whether giving a sour liquid early on can improve swallowing function in people who have trouble swallowing after a stroke. Researchers worked with 95 patients who had an acute ischemic stroke and developed dysphagia. They measured swallowing ability at the s…

This study looked at whether electroacupuncture (a type of acupuncture with mild electric pulses) can lower inflammation and help people recover after a stroke. 17 adults who had their first ischemic stroke took part. Researchers measured changes in symptoms and blood markers to …

This study tested whether vibration training can help people who recently had a stroke improve leg muscle strength, daily function, and mood. 148 patients took part. The approach uses whole-body vibration to stimulate muscles, aiming to speed recovery after a stroke.

This study looked at whether listening to self-chosen Italian music during and after a stroke hospital stay can improve mood, reduce anxiety and depression, and boost overall well-being. 150 stroke patients were randomly assigned to either regular music listening or standard care…

This study tested whether adding vibration therapy to standard rehabilitation could improve leg muscle strength, daily function, and emotional well-being in people who recently had a stroke. 115 hospitalized patients were randomly assigned to receive either standard care alone, s…

This study tested whether kinesio taping (a special elastic tape placed on the skin) can improve arm and hand function, reduce pain, and boost mood in people who recently had a stroke. 26 adults with arm weakness were randomly assigned to get either real kinesio taping or a fake …

This study looked at 34 adults with acute ischemic stroke and very high blood pressure. Researchers compared two drugs, nicardipine and labetalol, to see which one lowered blood pressure faster before stroke treatment. The goal was to find the best way to quickly and safely get b…

This study looked at whether giving the drug butylphthalide earlier (within 3 hours of a stroke) helps patients recover better than giving it later (3-6 hours). The trial involved 204 adults with acute ischemic stroke. Researchers measured recovery using standard disability and n…

This study looked at whether starting gentle exercise soon after a stroke helps patients regain daily living skills, feel less anxious or depressed, and improve their quality of life. 102 adults with acute stroke took part. The results suggest early mobilization may support both …

This study tested a new, powerful MRI scan on 56 stroke patients to see if it could detect subtle brain damage not visible on standard scans. The goal was to better understand how much brain tissue is truly saved after treatment. The findings could help doctors predict recovery m…

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand …

This pilot study tested a web-based tool designed to improve communication and decision-making between doctors and families of patients with severe acute brain injuries, such as stroke or traumatic brain injury. The tool helps prepare families for their role as decision-makers an…

This study looked at 481 stroke patients who had a procedure to remove a blood clot from their brain. Researchers compared those who received general anesthesia (fully asleep) versus sedation (awake but relaxed). They tracked death rates and recovery to see if one method was bett…

This study looked at 455 stroke patients to see if a continuous finger blood pressure monitor (Clearsight) or standard arm cuff measurements better predict brain bleeding after clot removal. Each patient had both methods used within 24 hours after treatment. The goal was to see w…

This study tested whether a special MRI scan called IVIM can predict how well people recover three months after an acute ischemic stroke. Researchers added a two-minute scan to the standard MRI for 274 adults admitted with stroke. They then compared the scan results to the patien…

This study looked at 174 adults who had a stroke and were treated under general anesthesia. Researchers compared removing the breathing tube early versus later to see which approach leads to better functional recovery after 90 days. The goal is to find the best time to take patie…

This study tested whether raising the legs (elevated leg positioning) is safe and practical for people who have had a moderate ischemic stroke. Fifty adults with moderate stroke symptoms were enrolled within 24 hours of symptom onset. The goal was to see if this simple, non-drug …

This Phase 1 trial tested the safety of LT3001, a potential clot-busting drug for acute ischemic stroke, in 65 healthy adults. Participants received multiple doses of LT3001 alone or with common stroke medications like aspirin and clopidogrel. The goal was to check for side effec…

This first-in-human study tested a new smart guidewire (Clotild®) in 45 stroke patients undergoing emergency clot removal. The wire helps guide the removal tool and also measures the clot's electrical properties to determine its composition. The main goal was to check safety, suc…

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This study tested a wearable sensor system (IMAS) to measure arm movement in 30 people who recently had a stroke. The goal was to see if the sensors could accurately predict how well arm function would recover. Researchers used motion data to build a model and compared it to stan…

This study tested whether an artificial intelligence (AI) tool called qER 2.0 EU helps doctors and other health professionals read head CT scans more accurately and quickly. Thirty-three readers, including radiologists, emergency doctors, and radiographers, reviewed 150 scans wit…

This study tested whether an artificial intelligence system that gives doctors feedback could improve the quality of emergency stroke treatment. Over 1,200 stroke patients were involved. The AI system aimed to help doctors make better decisions during a procedure to remove blood …

This study tested whether a mild electrical pulse on the ear (vagus nerve stimulation) can reduce inflammation after a stroke. Forty adults with a recent stroke received either standard care or standard care plus the ear stimulation. Researchers measured changes in blood markers …

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

This study looked at how often people have vision problems after a stroke. Researchers followed 127 stroke patients for 3 months, testing their eyesight and comparing results with brain scans. The goal was to find out how common these issues are and whether a simple vision screen…

This study looked at 400 stroke patients who had a clot-removal procedure (thrombectomy) within 24 hours of symptoms. Researchers wanted to find out which factors helped patients recover well, such as being able to walk independently. The goal is to better predict who benefits fr…