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Could inflammation after stroke trigger depression?

NCT ID NCT02368145

Knowledge-focused Sponsor: Alexander Kusnecov, Ph.D. Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study investigates whether inflammation and stress compounds in the blood are linked to depression after a stroke. Researchers measure inflammatory markers and stress hormones in blood samples from 25 adults who have had an acute ischemic stroke. Participants also complete depression and anxiety questionnaires at several time points over 90 days. The goal is to better understand the biological connection between stroke-related brain injury and mood changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If links are found, it could point toward new ways to predict or treat depression after a stroke.
What could go wrong
This is a small observational study with only 25 people, so results may not apply to everyone. It looks for patterns, not a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

25 people

The number who actually took part.

Start date

Jul 2013

Finished

Jun 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects with acute iechemic stroke

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The subjects will be male and female patients with acute ischemic stroke of the brain. Vascular risk factors, including diabetes, hypertension, and coronary artery disease, are expected to be common, and will be recorded in the Source Documents (appendix). Patients will be included if: * Aged ≥ 18 years of age * Neuroimaging or clinical symptoms are consistent with an acute ischemic stroke (AIS) * There are no alternative explanations for symptoms (eg. tumor, witnessed seizure, history of complicated migraine headache, hypoglycemia \[blood sugar (BS) \< 50 mg/dL\] or hyperglycemia (BS \> 400 mg/dL) * Subject is able to be enrolled and have blood samples drawn (Note: inability to provide a sample within 48 hours does not preclude inclusion if consent is provided after this time and patient can provide blood at subsequent time points (see Table) * Subject is able to provide informed consent for participation in this research study Exclusion Criteria: * • Other known severe/terminal illness which limits life expectancy to \< 90 days, sepsis, disseminated intravascular coagulopathy (DIC), infective endocarditis, metastatic cancer, or cerebral vasculitis * Current diagnosis of or treatment for major depressive disorder * Women who are pregnant at the time of stroke, since pregnancy alters inflammatory markers * Communication problems due to aphasia at visit 2, inability to speak English * History of substance abuse and other relevant psychiatric conditions * Autoimmune, current or recent infection, hematological disorders, use of immune modulating drugs

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute stroke Stroke

Contacts and locations

Locations

  • Rutgers, The State University

    New Brunswick, New Jersey, 08901, United States

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