ACUTE STROKE

This study tests whether a combination of small tube feedings plus extra IV nutrition can lower the chance of pneumonia in people with severe stroke. About 546 adults who have trouble swallowing will be randomly assigned to one of two feeding plans. The goal is to find a safer wa…

This study compares two types of general anesthesia during emergency clot removal for stroke patients. The goal is to see which method better maintains blood flow to the brain and improves recovery. About 90 adults with severe stroke will take part at two hospitals in Los Angeles…

This study tests if the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The mai…

This study tests an experimental drug called DM199 in people who have had a moderate stroke and cannot receive standard clot-removal treatments. About 728 participants will receive either DM199 or a placebo within 24 hours of their stroke. The goal is to see if the drug improves …

This study tests a new technique called ADAPT 2.0 that uses a special suction device to remove blood clots from the brain during a stroke. The goal is to see if it can safely and effectively restore blood flow better than current methods. About 750 adults having a stroke will tak…

This study tests whether giving stroke patients a custom nutrition plan within two days of their stroke can lower the chance of death within one month. About 3,084 adults with moderate to severe stroke will take part. A dietitian will check each patient's swallowing ability and f…

This study tests whether adding mirror therapy to standard physical therapy helps people who recently had a stroke regain arm and hand function. About 44 adults aged 40–55 with a stroke within the past month will take part. Participants will either get usual rehab or usual rehab …

This study tests whether a wearable robot can help people who recently had a stroke regain movement in their legs and improve balance. The robot assists with ankle exercises during intensive therapy. Researchers will compare recovery in 140 adults aged 18 to 80 who had a first st…

This study looks at two different ways to help people who recently had a stroke regain use of their arm. Forty participants will receive either isolated or combined muscle training for six weeks, followed by task practice. The goal is to see which approach better improves coordin…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers working on new ways to improve recovery. Anyone 18 or older with a past stroke and ongoing symptoms can join.

This study looks at whether an ultrasound of the vocal cords can help predict choking or pneumonia risk in people who recently had a stroke. Researchers will check vocal cord movement with ultrasound and then follow 200 participants for one year to see who develops choking or lun…

This study aims to build an AI system that predicts the best rehabilitation approach for each stroke survivor. Researchers will collect data from 400 participants aged 65-80 who had a stroke 1-6 months ago and have moderate-to-severe arm weakness. The AI will analyze brain scans,…

This study compares blood RNA patterns between 500 people who recently had a stroke and healthy volunteers. The goal is to find RNA molecules that can help doctors detect strokes earlier and predict how well patients will recover. No new treatments are being tested; this is a res…

This study explores whether simple body measurements, like muscle size and electrical properties, can help predict how well someone will recover after a stroke. Researchers will measure the thickness and surface area of a jaw muscle and use a special scale to assess body composit…

This study looks at whether a tool called the Modified SOAR score can help doctors predict which stroke patients are at higher risk of dying early in the hospital. Researchers will follow 60 adults admitted with acute stroke and track their health for the first 7 days. The goal i…

This study is observing 336 adults aged 18-85 who have had an acute ischemic stroke and are receiving a new clot-busting drug called non-immune staphylokinase. Researchers will track safety, especially bleeding in the brain, and compare results to the standard drug alteplase. The…

This study tests whether a special blood pressure cuff (Doctormate) can be used during helicopter transport to protect brain tissue in people having a severe stroke. Ten patients with large vessel occlusion will receive the treatment while being flown to a hospital for clot remov…