ACUTE ISCHEMIC STROKE

This study looks at whether a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar is common after a stroke and can lead to worse outcomes. The trial will c…

This study tests whether giving a clot-busting drug (rhPro-UK) before a standard clot-removal procedure helps stroke patients recover better. About 820 adults with a large-vessel blockage will receive either the drug or a placebo within 4.5 to 24 hours of their first symptoms. Th…

This study looks at the safety of two medicines that dissolve blood clots in the brain during a stroke. About 4,500 adults who have had a stroke will receive either the newer drug rhTNK-tPA or the standard drug rt-PA. Researchers will track how many people have serious bleeding i…

This study tests whether butylphthalide can reduce brain swelling and improve recovery in 100 adults who had a major stroke and received a procedure to reopen a blocked artery. Participants must be treated within 24 hours of stroke onset. The goal is to see if the drug helps cont…

This study compares two ways to remove large blood clots from the brain in people having a severe stroke. One method uses a super large suction tube, and the other uses a stent-like device to grab the clot. The goal is to see which approach leads to better recovery and less disab…

This study looks at people who had a major stroke caused by a big clot. Doctors remove the main clot, but sometimes smaller clots remain in other brain arteries. The trial will randomly assign 72 participants to either have those small clots removed too, or to leave them alone. T…

This study tests whether adding a PCSK9 inhibitor (a cholesterol-lowering drug) to standard care helps people recover better after a stroke caused by a blocked artery. About 478 adults with acute ischemic stroke who undergo endovascular therapy (a procedure to reopen the artery) …

This early-stage study tests the safety of a drug called EMPAVELI in 20 adults who had a stroke from a large blood clot and already had it removed. The drug is given through a pump shortly after the procedure and again at 24 and 48 hours to reduce swelling and inflammation when b…

This early study tests if a new injection method can safely deliver a drug called RK-4 directly to the brain in people with severe stroke. The drug is given through a small hole in the skull, bypassing the blood-brain barrier. Only 6 people will take part, and the main goal is to…

This early-stage study tests whether a drug combination (chlorpromazine and promethazine) that induces a hibernation-like state is safe for people having a severe stroke. About 57 adults aged 18-80 who are eligible for clot-removal therapy will receive the drugs. The main goal is…

This study tests whether adding a drug called GM1 to standard clot-removal treatment helps people recover better after a major stroke. About 868 adults with a blocked artery in the front part of the brain will receive either GM1 or a placebo. The goal is to see if more patients c…

This study looks at the best way to treat stroke patients who have high blood pressure and need clot-busting medicine. Currently, doctors lower blood pressure first, then give the clot-buster. This trial tests if giving both treatments at the same time is safer and leads to bette…

This study tests whether a drug called tenecteplase, given directly into the brain artery, can help people who have had a stroke from a medium-sized blood clot. About 488 adults with stroke symptoms starting within 24 hours will receive either standard care or standard care plus …

This study tests whether giving the drug eptifibatide soon after standard clot-dissolving treatment can improve recovery in people with acute ischemic stroke who arrive at the hospital 4.5 to 24 hours after symptoms start. About 786 adults will be randomly assigned to receive ept…

This study tests a new catheter device designed to remove blood clots from the brain in people having an acute ischemic stroke. About 45 participants will be treated within 24 hours of their first symptoms. The goal is to see if the device can safely restore blood flow and improv…

This study tests a nasal spray made from human stem cell exosomes (tiny particles that help cells communicate) in people who recently had a stroke. The spray is given once or daily for 14 days, alongside standard care. The goal is to see if it is safe and whether it can improve b…

This study tests whether the drug J147, given by IV along with standard clot-removal therapy, helps people recover better after an ischemic stroke. About 196 participants will receive either J147 or a placebo, and researchers will monitor brain scans, blood tests, and function ov…

This study tests a new device called the iNstroke catheter to remove blood clots from the brain in people having a stroke. About 160 adults will be treated within 24 hours of their first symptoms. The goal is to see if the catheter can safely restore blood flow and improve outcom…

This study looks at how well two drugs, edaravone and dexrazoxane, help people recover from a mild to moderate stroke. Researchers will track 600 adults over time to see if these drugs improve daily function and reduce disability. The goal is to find out which drug works best and…

This study tests whether cooling the head, starting as early as possible and continuing until one hour after blood flow is restored, can reduce the amount of brain tissue damaged by a stroke. About 182 adults with a severe type of stroke will be randomly assigned to receive eithe…

This study tests whether the drug tenecteplase can help people who have had a major stroke but cannot get surgery to remove the clot. About 794 adults will receive either the drug or standard care within 4.5 to 24 hours of their first symptoms. The main goal is to see if more peo…

This study tests whether adding the blood thinner tirofiban after standard stroke treatment helps people recover better from a severe stroke caused by plaque buildup in a large artery. About 564 adults in China will receive either tirofiban or usual care after a clot-removal proc…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen) can improve recovery in people who had a stroke and received a procedure to reopen a blocked artery. About 424 adults aged 35-75 will receive 10 one-hour sessions over 5 weeks. Researchers…

This study tests if the clot-busting drug tenecteplase can help people who have a stroke and are treated 4.5 to 9 hours after symptoms begin. About 564 participants will receive either tenecteplase or a placebo, along with aspirin. The goal is to see if the drug improves recovery…

This study tests if placing a stent after removing a clot can help stroke patients with severely narrowed brain arteries. About 342 adults aged 18-80 who have had a major stroke will be randomly assigned to get a stent or not. The goal is to see if stenting improves recovery and …

This early-phase study tests a new drug called RK-4 for people with a severe type of stroke (large hemispheric infarction) who cannot have standard treatment. The drug is injected directly into the skull bone marrow once daily for three days. The main goals are to check if the dr…

This study tests whether giving a clot-preventing drug called tirofiban directly into the brain artery right after a clot is removed can help stroke patients recover better. About 344 adults who had a major stroke from a blocked artery will be randomly assigned to receive either …

This study tests whether a smartphone app that gives personalized health tips can help people who have had a stroke lower their risk of having another one. About 5,000 adults aged 40 to 80 who recently had a stroke will use the app or receive standard care. The main goal is to se…

This study tests whether giving an extra dose of the clot-busting drug prourokinase can help stroke patients with medium or large blocked brain arteries who don't improve after the first dose. About 122 adults will be enrolled within 4.5 hours of stroke onset. The goal is to see …

This study tests whether adding the drug sivelestat sodium to standard clot-removal surgery helps people recover better from a severe stroke. About 868 adults with a large-vessel blockage in the brain will receive either the drug or a placebo. The goal is to see if the drug reduc…

This study tests a mobile app that gives personalized warnings about temperature-related health risks and helps manage stroke risk factors. Over 10,000 people who recently had a stroke will use the app to see if it lowers their chance of having another stroke within a year. The g…

This study tests a new drug called RK-4 for people who have had a severe stroke and cannot receive standard treatment to reopen blocked blood vessels. The drug is injected into the skull bone marrow daily for three days. Researchers want to see if it helps patients recover better…

This study tests whether the clot-busting drug tenecteplase can help people who wake up with stroke symptoms but don't know when the stroke started. About 352 adults with moderate to severe stroke will receive either tenecteplase or standard care after a non-contrast CT scan. The…

This study tests whether adding a drug called human urinary kallidinogenase (HUK) to standard clot-busting therapy (reteplase) helps people recover better after a stroke. About 220 adults who have had a moderate stroke within the last 4.5 hours will receive either the combination…

This study tests a device called I-NIC that uses low-frequency magnetic stimulation to help people recover from a stroke. About 364 participants will receive either the real device or a placebo, along with standard care, for 5 days starting within 48 hours of their stroke. The go…

This study tests a new bedside blood test that may quickly tell if a child is having a stroke. Researchers will check how accurate the test is in 250 children who come to the ER with stroke symptoms. The goal is to speed up diagnosis and treatment, while children still receive st…

This study tests a smartphone app that gives early warnings and advice when temperatures pose a health risk. About 5,000 people who recently had a stroke will use the app for one year. The goal is to see if these alerts help lower the chance of having another stroke.

This study tests a Chinese herbal medicine called Xinglou Chengqi Granule in 60 people who recently had an acute ischemic stroke. The goal is to find the best dose and see if it helps improve stroke symptoms and daily function. Participants will be monitored for up to 90 days.

This early-stage trial tests whether a drug called anisodine hydrobromide is safe for people who have had a stroke and are undergoing a procedure to remove a blood clot. The study will include 92 adults aged 18 to 80 with a specific type of stroke. Researchers will monitor for se…

This study tests whether adding brain-computer interface (BCI) training to standard rehabilitation helps people recover arm and leg movement after a stroke. Sixty adults aged 18–80 who had a stroke and received clot-busting treatment will be randomly assigned to either standard r…

This study compares a new 'one-stop' emergency stroke unit that combines CT and DSA scans in one room to the usual step-by-step imaging process. The goal is to see if faster diagnosis and treatment helps more people recover independently within 90 days after a severe stroke. Abou…

This study looks at 100 adults who had a stroke caused by a large blood clot in the front part of the brain and underwent a procedure to remove it. Researchers will use a special ultrasound (transcranial Doppler) to measure blood flow in the brain after the procedure. The goal is…

This study looks at a specific type of stroke called Branch Atheromatous Disease (BAD), where a small artery deep in the brain gets blocked. Researchers will compare three treatments: a clot-busting drug (IV thrombolysis), one antiplatelet drug, or two antiplatelet drugs. They wi…

This study tests a computer system called LingBao that helps doctors decide the best treatment for people having a stroke. About 3,000 adults who arrive at the hospital within 24 hours of stroke symptoms will take part across 20 stroke centers. The AI reviews patient data and sug…

This study looks at how a gene called GGCX affects recovery after a stroke caused by a blood clot. Researchers will collect blood from 1,500 stroke patients and track their health for one year. The goal is to see if certain gene changes are linked to a higher risk of another stro…

This study looks at how well and how safely the clot-busting drug tenecteplase works in very old patients (80 years or older) who have had a stroke. Researchers will track 392 patients for 90 days to see if they recover with little or no disability. The goal is to gather real-wor…

This study will observe 3,000 stroke patients in China who receive clot-busting medication more than 4.5 hours after their symptoms began. The goal is to see if this late treatment is safe and helps reduce disability. Participants will be followed for 90 days to measure their rec…

This study looks at whether blood electrolyte levels are linked to kidney injury in people having a stroke procedure. Researchers will review records of 250 stroke patients to compare those who developed kidney problems with those who did not. The goal is to find new ways to pred…

This study looks at whether giving the clot-busting drug tenecteplase more than 4.5 hours after a stroke starts is safe and helpful. Researchers will follow 3,000 adults in China who receive this late treatment in regular hospital care. The goal is to see if patients have less di…