Could a cholesterol drug boost stroke recovery?

NCT ID NCT07174375

Not yet recruiting Disease control Sponsor: Nanfang Hospital, Southern Medical University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether adding a PCSK9 inhibitor (a cholesterol-lowering drug) to standard care helps people recover better after a stroke caused by a blocked artery. About 478 adults who had a stroke and received a procedure to reopen the blocked vessel will be randomly assigned to get the drug or not. The main goal is to see if more people achieve a good functional outcome (able to live independently) at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PCSK9 inhibitors (Evolocumab or Alirocumab)
What this could lead to: If successful, this could show that adding a cholesterol-lowering drug after stroke treatment improves recovery and reduces the chance of another stroke.
What could go wrong: This is an early-to-mid stage trial, so results may not be conclusive. The drug may not provide additional benefit over standard care, and there are risks like injection site reactions or muscle pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE

Contacts and locations

Locations

Dongguan Donghua Hospital

Dongguan, Guangdong, China
Dongguan People's Hospital

Dongguan, Guangdong, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, China
Ganzhou City People's Hospital

Ganzhou, Jiangxi, China
Haikou People's Hospital

Haikou, Hainan, China
Hainan Provincial Hospital of Traditional Chinese Medicine

Haikou, Hainan, 570100, China
Hainan Provincial People's Hospital

Haikou, Hainan, China
Hengzhou City People's Hospital, Guangxi

Hengzhou, Guangxi (Autonomous Region), China
Heyuan People's Hospital

Heyuan, Guangdong, China
Huadu District People's Hospital of Guangzhou

Guangzhou, Guangdong, China
Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, China
The Second Affiliated Hospital of Hainan Medical University

Haikou, Hainan, China

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