Could a common drug prevent brain swelling after stroke?

NCT ID NCT07528456

Not yet recruiting Disease control Sponsor: Nanfang Hospital, Southern Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug butylphthalide can reduce brain swelling in people who have had a severe stroke and undergone a procedure to reopen a blocked artery. About 100 adults will receive either the drug or a placebo for up to 14 days. Researchers will measure changes in spinal fluid and brain scans to see if the drug helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: butylphthalide
What this could lead to: If it works, this could point toward a new way to reduce dangerous brain swelling after a stroke, potentially improving recovery.
What could go wrong: This is a small, early-phase trial with only 100 people. The drug may not reduce swelling better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain edema ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE

Contacts and locations

Locations

Dongguan People's Hospital

Dongguan, Guangdong, China
Ganzhou People's Hospital

Ganzhou, Jiangxi, China
Haikou People's Hospital

Haikou, Hainan, China
Hainan Provincial Hospital of Traditional Chinese Medicine

Haikou, Hainan, China
Heyuan People's Hospital

Heyuan, Guangdong, China
Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, 510515, China
Qingyuan People's Hospital

Qingyuan, Guangdong, China
The Fourth Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
The Second Affiliated Hospital of Hainan Medical University

Haikou, Hainan, China
Yuebei People's Hospital

Shaoguan, Guangdong, China

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