Skull injection could bypass brain barrier for stroke patients

NCT ID NCT07514949

Not yet recruiting Disease control Sponsor: yilong Wang Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is feasible and safe, not yet to prove it improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RK-4 (a neuroprotective drug)
What this could lead to: If successful, this could point toward a new way to deliver stroke treatments directly to the brain, potentially improving recovery for patients who cannot have standard clot-removal therapy.
What could go wrong: This is a very early, tiny pilot study with only 6 people. It is designed mainly to check safety and whether the injection method works, not to prove the drug helps. There are risks like infection, bleeding, or the procedure being too uncomfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain infarction ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE BLOOD-BRAIN BARRIER STROKE

Contacts and locations

Locations

Beijing Tiantan Hospital

Beijing, China

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Other studies related to the condition(s) this trial covers.