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Brain scans face off: can a quick CT match MRI's accuracy in stroke care?

NCT ID NCT07719374

Diagnosis Sponsor: Fondation Ophtalmologique Adolphe de Rothschild Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Sep 03, 2026 · Updated 3 times

Summary

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred adults with stroke symptoms and a high NIHSS score will be randomly assigned to one of the two imaging paths. The study will measure costs, quality of life, treatment speed, and clinical results over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MRI and MR angiography (MRA) or CT and CT angiography (CTA) as first-line diagnostic imaging
What this could lead to
If CT proves as effective and more cost-efficient than MRI, it could speed up stroke diagnosis and treatment in hospitals with limited MRI access.
What could go wrong
CT may miss early ischemic changes that MRI detects, potentially affecting treatment decisions. The trial's results depend on real-world hospital workflows and patient selection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Symptoms consistent with suspected acute ischemic stroke due to proximal large vessel occlusion * National Institutes of Health Stroke Scale (NIHSS) score ≥10 at admission * Symptom onset \<6 hours before randomization Exclusion Criteria: * Previous diagnostic brain imaging performed within the preceding 24 hours for the index stroke event * Contraindication to MRI (e.g., cardiac pacemaker, metallic implant or foreign body, surgical clips) or CT (e.g., pregnancy, severe renal impairment) * Contraindication to iodinated contrast agent (e.g., known severe allergy) * Not affiliated with the French national health insurance system * Not residing in France * Pregnant or breastfeeding * Adults under legal protection * Participation in another interventional clinical trial (RIPH1 or equivalent)

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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