Fondation Ophtalmologique Adolphe De Rothschild

This study tests whether adding a fast-acting blood thinner (cangrelor) to the standard mechanical clot removal procedure improves recovery for people with acute ischemic stroke. About 368 adults with a blocked artery in the brain will be enrolled within 24 hours of symptoms. The…

This study compares two invasive treatments for idiopathic intracranial hypertension (IIH) when standard medication fails. IIH causes high pressure in the skull, leading to vision loss. The trial will test if a venous sinus stent (a tube placed in a brain vein) or a neurosurgical…

This early-stage study tests whether a combination of an anti-inflammatory drug (etanercept) and repeated ultrasound can safely open the blood-brain barrier in people with mild Alzheimer's disease. The goal is to let more medication reach the brain. Only 5 participants will be en…

This study tests whether a daily IV dose of dornase alfa (a drug currently used for cystic fibrosis) given for up to 14 days after a brain aneurysm rupture can help patients regain independence at 6 months. The drug targets tiny blood clots and inflammation in the brain that ofte…

This study tests whether starting steroids right away, followed by rituximab if symptoms return, can prevent eye muscle weakness from spreading to other muscles in people with ocular myasthenia gravis. About 128 adults diagnosed within the last 6 months will be randomly assigned …

This study looks at whether people with active multiple sclerosis (MS) who have been on ocrelizumab for at least 2 years can safely switch to getting infusions once a year instead of every 6 months. The goal is to see if the longer gap still prevents new brain lesions while lower…

This study tests whether the drug bevacizumab, given through a vein, can improve disabling symptoms like headaches, seizures, and thinking problems in people with brain arteriovenous malformations (AVMs) that cannot be treated with standard procedures. About 54 adults with modera…

This study aims to improve the diagnosis of a rare, non-cancerous brain tumor called MVNT using ultra-high resolution MRI scans. Currently, standard scans can leave uncertainty, leading some patients to have invasive surgery to remove a harmless growth. By comparing standard and …

This study compares a new MRI technique called MP2RAGE with standard scans to see if it can find more spinal cord lesions in people with multiple sclerosis (MS). About 196 adults with MS will get both types of scans, and two radiologists will count the lesions without knowing whi…

This study tests whether lower-resolution MRI scans can still accurately detect giant cell arteritis, a serious inflammation of the arteries that can cause blindness or stroke if not treated quickly. Researchers will compare different MRI techniques in 133 adults suspected of hav…

This study compares two ways to screen men at high risk for abdominal aortic aneurysm (AAA): having their general practitioner use a small, portable ultrasound device during a regular visit versus the current standard of referring them to a radiologist. The goal is to see if the …

This study tests whether an optimized MRI scan can more accurately detect anterior ischemic optic neuropathy (a type of eye stroke) in people with sudden vision loss. Researchers will add an 8-minute scan to the standard brain and visual MRI. The goal is to see if this faster sca…

This study looks at whether having cataract surgery on both eyes on the same day is as safe and effective as the usual approach of operating on each eye weeks apart. Researchers will compare costs and quality of life for 242 adults in France who need surgery for both eyes. The go…

This study aims to create a database of images and videos of the eye's blood vessels using a new device called a holographic Doppler laser. Researchers want to see if this laser can clearly show arteries and veins and measure blood flow in the retina. About 123 adults, both with …

This study looks at how Wilson's disease may affect the heart due to copper buildup. Researchers will use heart scans, blood tests, and heart monitors to check for damage in 150 adults with the condition. The goal is to better understand heart problems in Wilson's disease and imp…

This study looks at platelets (small blood cells) found in brain and spinal cord tumors. Researchers want to see if platelets help tumors grow or spread, and if their presence is linked to patient survival. About 50 adults having tumor surgery will donate a small piece of their t…

This pilot study aims to describe lymphatic damage in people with brain vein narrowing or clots using a special MRI sequence. About 100 adults who already need an MRI for their condition will get extra scans. The goal is to see if this new method can detect lymph nodes or bundles…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes used during surgery. The goal is to better understand the root causes of thes…

This study looks at copper levels in breast milk from 20 women with Wilson's disease who are on treatment. The goal is to understand if breastfeeding is safe for their babies. Researchers will measure copper in milk samples taken shortly after childbirth.

This study looks at how children's brains process language as they grow. Researchers will record brain activity from children (ages 2-20) who already have electrodes implanted for epilepsy monitoring. While listening to stories, their brain signals will reveal how the brain combi…

This study looks at two treatments made from a person's own blood to help heal the cornea (the clear front part of the eye) in people with aniridia, a rare eye condition. The goal is to see if growth factor-rich plasma works better than the usual autologous serum at healing corne…

This study looks at whether a special MRI scan can predict how well children with retinoblastoma (a rare eye cancer) will respond to chemotherapy delivered directly to the eye. Researchers will follow 60 children for 18 months after treatment to see if the MRI findings match the …

This study follows 2000 adults who had a brain aneurysm treated with a procedure called embolization. The goal is to collect standard long-term data to see how often the aneurysm reopens and requires another treatment. Participants will have regular check-ups to monitor their con…

This study aims to see if a special type of MRI, called resting-state fMRI, can help predict how well people with optic neuritis (inflammation of the optic nerve) will recover their vision. Researchers will scan the brains of 200 adults with suspected optic neuritis and compare t…

This study looks at how the brain's visual networks change in people with inherited retinal diseases. Researchers will use MRI scans to map brain connections before and after treatments like retinal implants or optogenetics. The goal is to understand how the brain adapts to visio…

This study surveys 400 adults with epilepsy in France to understand why they are less physically active than others. Researchers will look at how fear, stigma, and personal beliefs affect exercise habits. The goal is to find ways to help people with epilepsy be more active and im…

This study aims to improve the quality and comfort of MRI scans by testing new imaging sequences. About 750 adults will have both the standard MRI and experimental versions, with experts comparing image sharpness, artifacts, and diagnostic confidence. The goal is to find sequence…

This study tests whether a type of MRI scan, called resting-state fMRI, can predict how well children with drug-resistant epilepsy will do after brain surgery. Researchers will scan 200 children aged 6 to 18 before surgery and check their seizure control one year later. The goal …

This study tests whether a high-resolution MRI can more accurately show the position of a parotid tumor relative to the facial nerve before surgery. About 88 adults scheduled for first-time parotid tumor removal will receive the special MRI. The goal is to help surgeons plan bett…

This study explores whether combining a driving simulator with an EEG (a brain activity test) can better assess driving ability in people with epilepsy. Researchers will measure attention, reaction time, and driving performance in 40 adults with epilepsy who hold a valid driver's…

This study uses two types of eye imaging (OCT-A and adaptive optics) to look for changes in the retina that might be linked to memory problems, including Alzheimer's and other dementias. Researchers will compare 450 people with and without memory complaints to see if these scans …

This study looks at tiny markers on the surface of eye cells in people with severe dry eye. Researchers want to see how these markers change before and after starting treatment. The goal is to better understand the disease, not to test a new cure. About 100 adults with severe dry…

This study looks at the clots removed from people having a stroke to understand how their composition relates to blood markers, how well treatment works, and the cause of the stroke. Researchers will analyze 1,200 patients' clots and blood samples. The goal is to learn more about…

This study compares two imaging methods—MRI and ultrasound—for looking at the layers of the eye in 30 adults. Participants will have both an eye ultrasound and a high-resolution MRI with a contrast dye. The goal is to see where the two methods agree or disagree, which could help …

This study follows 1,000 nearsighted children in Europe to track how their eyes grow over time. Researchers will use eye exams and special imaging to understand why some children become more nearsighted than others. The goal is to improve future treatments for myopia, which is be…

This study looks at how seizures change the brain's connections in children with epilepsy that doesn't improve with medication. Researchers will use special brain scans and recordings from inside the brain to map these changes. The goal is to understand the disease better, not to…

This study looks at the genes of 300 people with brain or spinal cord arteriovenous malformations (AVMs) to see how genetic changes affect the disease's outlook. Researchers will test blood and tissue samples to find mutations linked to bleeding risk. The goal is to better unders…

This study is testing a new, more detailed MRI sequence (3D FGAPSIR) to see if it can find spinal cord injuries that standard scans miss in people with multiple sclerosis. About 200 adults will get an extra 10-minute scan during their regular MRI. The goal is to improve detection…

This study looks at specific blood markers related to inflammation and clotting in people who have lost oxygen to the brain due to stroke or bleeding. Researchers will compare these markers between affected patients and those without brain oxygen loss. The goal is to better under…

This study looks at why some stroke patients still have poor outcomes even after successful clot removal. Researchers will compare MRI scans with brain tissue samples from 15 patients who need surgery to relieve brain pressure. The goal is to see if certain MRI signals indicate t…

This study is looking for 100 adults with drug-resistant epilepsy to see if their body odor changes before a seizure. Researchers will collect scent samples and analyze them to find unique chemical markers. If successful, this could lead to a non-invasive device that warns people…

This study looks at how the brain learns to control fine movements, like playing an instrument, by recording brain activity during awake surgery. About 50 people with epilepsy or brain tumors will use a theremin-like device while their brain signals are recorded. The goal is to b…

This study is testing a new virtual reality (VR) test called VisionumVR to see if it can reliably measure how well people with low vision improve during rehabilitation. About 60 participants who are starting or already in vision therapy will use a VR headset to perform a 20-minut…

This study aims to find biological markers (biomarkers) in the blood of people with ALS that can show whether a potential new treatment is working. Researchers will collect tiny particles released by nerve cells from blood samples of 30 ALS patients and 30 healthy volunteers. By …

This study looks at how the body's immune and inflammatory systems react in the first 24-36 hours after a stroke treated with a clot removal procedure (thrombectomy). Researchers will analyze blood samples from 1,200 participants to find patterns that might predict how well peopl…

This study looks at whether sinus infections (sinusitis) are common in people with wet age-related macular degeneration (AMD) who need frequent eye injections. Researchers will check 200 participants for sinusitis and see if treating it reduces the number of injections needed. Th…

This study examines whether damage to the glycocalyx, a protective lining inside blood vessels, is linked to glaucoma. Researchers will compare 100 adults with and without glaucoma using a non-invasive test. The goal is to find new ways to detect or understand the disease, not to…

This study collects data on how well patients recover neurologically 3 months after endovascular treatment for an acute ischemic stroke. It involves 5,000 participants and focuses on a key recovery score that is rarely measured at this stage. The goal is to better understand pati…

This study follows 80 people who need DMEK eye surgery after having other eye surgeries like vitrectomy or glaucoma surgery. The goal is to see how often serious problems like graft detachment or rejection happen within 12 months. Researchers hope to show that DMEK can still be a…

This study looks at how Wilson's disease affects dental health. Researchers will compare the teeth and gums of people with two forms of the disease (liver and brain) and healthy volunteers. The goal is to understand the link between the disease and oral health problems, which cou…

This study aims to collect long-term follow-up data from 1000 adults who have had embolization for brain arteriovenous malformations (AVMs). Currently, there are no standard guidelines for how long or how often to monitor these patients after treatment. By gathering consistent in…

This study looks for links between specific genes and the severity of eye surface disease in people with inherited conditions. Researchers will examine 60 participants to see which genetic changes lead to the worst symptoms. No treatment is given; the goal is to better understand…

This study looks at how chronic pain changes the brain's reward system, making it harder to learn from rewards. Researchers will compare 50 people with chronic pain to healthy volunteers using brain scans and a learning task. The goal is to understand the brain mechanisms behind …