Could MS patients switch to once-yearly infusions? new trial aims to find out

NCT ID NCT05999604

Recruiting now Disease control Sponsor: Fondation Ophtalmologique Adolphe de Rothschild Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether people with active multiple sclerosis who have been stable on Ocrevus for at least two years can safely switch to annual infusions instead of the standard every-6-month schedule. The goal is to see if the less frequent dosing is just as good at preventing new brain lesions, while potentially lowering infection risk and reducing hospital visits. About 244 adults will be randomly assigned to receive Ocrevus either once or twice a year for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ocrelizumab (Ocrevus)
What this could lead to: If successful, this could allow people with stable MS to receive infusions once a year instead of twice, reducing infection risk and treatment burden.
What could go wrong: This is a non-inferiority trial, so it may show that annual dosing is slightly less effective at preventing new brain lesions. The study is also relatively small (244 people) and only follows participants for two years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MULTIPLE SCLEROSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

CH Gonesse
RECRUITING

Gonesse, 95500, France
CHI Poissy-Saint-Germain en Laye
RECRUITING

Poissy, 78300, France
CHU de Grenoble
RECRUITING

Grenoble, 38043, France
CHU de Limoges
RECRUITING

Limoges, 87042, France
CHU de Nice
RECRUITING

Nice, 06000, France
CHU de Strasbourg
RECRUITING

Strasbourg, 67098, France
Fondation Adolphe de Rothschild
RECRUITING

Paris, 75019, France
Hôpital Foch
RECRUITING

Suresnes, 92150, France
Hôpital Henri Mondor
RECRUITING

Créteil, 94010, France
Hôpital Pierre Wertheimer (HCL)
RECRUITING

Lyon, 69500, France
Hôpital de la Pitié-Salpêtrière
RECRUITING

Paris, 75013, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.