MULTIPLE SCLEROSIS

This early-stage study tests two new long-acting injections, IVL3004 and IVL4002, in 40 healthy men aged 18-55. The goal is to see how the body processes these drugs compared to the approved medication Vivitrol, and to check for safety. If successful, these injections could offer…

This study looks at whether people with early relapsing multiple sclerosis (MS) can stop taking the drug ocrelizumab after two years and still stay relapse-free. About 123 participants will receive the drug for two years, then be randomly assigned to continue the drug or switch t…

This study tests whether a drug used for diabetes can slow brain shrinkage in people with multiple sclerosis (MS). The drug works by reducing inflammation, which may protect the brain and eyes. About 120 adults with stable MS will receive either the drug or a placebo for 96 weeks…

This study will follow 2000 people with relapsing multiple sclerosis who are prescribed BRIUMVI, a medication given by infusion. Researchers want to see how well the drug works in everyday life and track any side effects. Participants must not have received BRIUMVI before and can…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests an experimental mRNA medicine called mRNA-1195 in 180 adults aged 18 to 55 with relapsing multiple sclerosis. The main goal is to check if the treatment is safe and what side effects it may cause. Participants will receive either the study drug or a placebo injec…

This study compares two versions of the multiple sclerosis (MS) drug ocrelizumab given as a shot under the skin. About 182 adults with relapsing or primary progressive MS will get one dose of either the test or the marketed version. The goal is to see if the test version works ju…

This study tests whether metformin, a diabetes drug, is safe and can protect the brain in people aged 55–75 with multiple sclerosis (MS). Participants will take metformin or a placebo for 9 months, either alone or with their usual MS treatment. The goal is to see if metformin red…

This early study tests whether a new treatment called GC012F (a CAR T cell injection) is safe and tolerable for people with multiple sclerosis. About 15 participants will receive the therapy and be monitored for side effects over 15 years. The goal is to see if this immune-cell a…

This early-phase study tests a new treatment called KITE-363 for people with severe autoimmune nerve diseases like multiple sclerosis, myasthenia gravis, and chronic inflammatory demyelinating polyneuropathy that haven't responded to standard therapies. KITE-363 uses a patient's …

This early-stage study tests a new treatment called CC-97540, which uses a patient's own immune cells (CAR T cells) to target and calm the immune system in people with multiple sclerosis or myasthenia gravis. The main goal is to check safety and find the right dose. About 120 adu…

This study compares two drugs, rituximab and ocrelizumab, for people with relapsing-remitting multiple sclerosis (MS). The goal is to see if rituximab works as well as ocrelizumab at preventing MS attacks and new brain lesions over two years. About 386 adults aged 18-55 with acti…

This study tests a new treatment called MB-CART 2019.1 for people with active multiple sclerosis (MS) that hasn't responded to other therapies. The treatment uses a patient's own immune cells, modified in a lab to target and attack harmful immune cells driving MS. The goal is to …

This study tests whether taking a probiotic twice a day for six months can help people with relapsing-remitting multiple sclerosis (RRMS). The goal is to see if the probiotic increases certain immune cells that may calm the disease. 80 adults with RRMS will be randomly assigned t…

This study tests a new drug called VT7208 for multiple sclerosis (MS). It first checks safety and how the drug works in healthy volunteers, then tests it in people with MS. The goal is to see if the drug is safe and how the body processes it. About 100 people will take part.

This study tests whether starting the MS drug natalizumab within 14 days of first symptoms can help repair nerve damage in the brain. About 40 adults with early signs of multiple sclerosis will receive either the drug or a placebo for 12 weeks. The goal is to see if quick, strong…

This study looks at whether people with active multiple sclerosis (MS) who have been on ocrelizumab for at least 2 years can safely switch to getting infusions once a year instead of every 6 months. The goal is to see if the longer gap still prevents new brain lesions while lower…

This early-phase study tests a new treatment called KYV-101 for people with progressive forms of multiple sclerosis (MS) that are not responding to standard therapies. The treatment uses a patient's own immune cells, modified to target and remove faulty immune cells that may driv…

This study looks at whether following the MIND diet—a mix of Mediterranean and DASH diets—can protect the brain and improve symptoms in people with multiple sclerosis (MS). About 100 adults with MS will either follow the MIND diet for one year or continue their usual eating habit…

This study looks at whether adding a GLP-1 agonist (a type of diabetes drug) to the MS treatment ocrelizumab can reduce disability progression in people with multiple sclerosis. Researchers will track 100 adults over 72 weeks to see if the combination helps control the disease be…

This study tests if a monthly shot of frexalimab works as well as the IV version for adults with multiple sclerosis. About 160 people aged 18-60 will take part. The goal is to see if the shot is safe and keeps the disease under control, offering a more convenient option.

This study is testing whether a 3-month exercise program that combines aerobic, strength, and balance training can help people with multiple sclerosis. The program is done both in person and through online videos. Researchers will measure changes in disease activity, walking spee…

This study offers ongoing treatment with ocrelizumab to about 500 adults with multiple sclerosis who were in earlier Roche-sponsored trials and lack other access. Researchers will track how the drug affects physical function, safety, and daily life over time. The goal is to keep …

This early-stage study tests a new treatment using specially engineered immune cells (CAR T-cells) that target two proteins, CD19 and BCMA, to calm overactive immune attacks in people with relapsed or hard-to-treat neurological autoimmune diseases like multiple sclerosis, myasthe…

This study tests the safety and effectiveness of Ublituximab (Briumvi) given twice a year for early relapsing multiple sclerosis. About 40 adults with mild disability will receive the drug and be monitored for about a year. Researchers will measure nerve damage markers in the blo…

This study looks at how well the drug ofatumumab works for people with relapsing multiple sclerosis (RMS) in everyday medical practice. It will measure changes in a blood marker called sNfL, which indicates nerve damage. About 80 adults with RMS will take ofatumumab and be follow…

This early-stage study tests whether repeated injections of stem cells from donated fat tissue are safe for people with primary progressive multiple sclerosis (MS), a form that steadily worsens. Ten adults aged 18–55 with moderate disability will receive the cells directly into t…

This early-stage trial tests a new treatment called AZD0120 for people with multiple sclerosis (MS) that has not responded to other therapies. The treatment uses a patient's own immune cells, modified to target and attack harmful cells linked to MS. The main goal is to check if t…

This early-stage trial tests TRX319, a cell therapy, in 39 adults with primary or secondary progressive MS. The goal is to see if it is safe, find the best dose, and check if pre-treatment with another drug helps it work. Participants receive up to 3 doses over a year and undergo…

This study tests whether a smartphone app can record and analyze speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study compares a new MRI technique called MP2RAGE with standard scans to see if it can find more spinal cord lesions in people with multiple sclerosis (MS). About 196 adults with MS will get both types of scans, and two radiologists will count the lesions without knowing whi…

This study compares the latest 2024 McDonald criteria with the 2017 version for diagnosing multiple sclerosis (MS) in everyday medical practice. Researchers will enroll 100 people with symptoms suggestive of MS and track them for two years. The goal is to see if the new criteria …

This study aims to see if specific signs on MRI brain scans can help doctors more accurately diagnose multiple sclerosis (MS) and track how it changes over four years. Researchers will follow 40 people already in a related study, using detailed MRI scans to look for 'central vein…

This study tests whether a home-based, internet-delivered physical activity program can improve cognitive processing speed (thinking speed) in people with multiple sclerosis who have mild walking difficulties. Researchers will compare the exercise program to an active control con…

This study looks at whether a short, high-dose course of corticosteroids can help heal a specific type of brain lesion in people with multiple sclerosis (MS). About 30 adults with MS who have a ring-enhancing lesion on their MRI will either receive the steroid treatment or no tre…

This study tests a treatment called cryoneurolysis, which uses controlled freezing to calm overactive nerves that cause pain and stiffness in people with brain or spinal cord conditions like stroke, multiple sclerosis, or injury. About 50 adults will be randomly assigned to get e…

This study tests whether laughter yoga, a practice combining breathing exercises and laughter, can reduce pain, stress, and fatigue in people with multiple sclerosis. Researchers will measure changes in pain levels, stress, and a natural feel-good chemical called beta-endorphin. …

This study is testing a robotic leg brace (exoskeleton) that also delivers small electrical pulses to muscles, to see if it is safe and helps people with brain injury, spinal cord injury, or multiple sclerosis walk better. About 15 adults aged 18-80 who are already in physical th…

This study tests whether relaxation, activity planning, and cognitive therapy can reduce fatigue and improve daily functioning in adults with multiple sclerosis. About 112 participants will be randomly assigned to different combinations of these therapies. The goal is to find whi…

This study is testing a wearable suit called Mollii that uses mild electrical pulses to improve movement and quality of life in people who have had a stroke or have multiple sclerosis. About 40 participants will wear either the active suit or a placebo version to see if it helps …

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve overactive bladder symptoms (like frequent or urgent urination) in women with multiple sclerosis. Participants will receive either real or sham stimulation over 10 sessions, and re…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce muscle spasticity and improve balance in people with multiple sclerosis. About 24 adults aged 18–60 with MS and mild-to-moderate spasticity wi…

This study tests whether combining cognitive rehabilitation with exercise can improve learning and memory in people with multiple sclerosis who have trouble walking. About 78 participants will be assigned to different treatment groups to compare the effects. The goal is to find a…

This study tests a powered knee-ankle-foot orthosis (KAFO) called Nomad in 36 people who have trouble walking due to conditions like stroke, spinal cord injury, or multiple sclerosis. Participants will use the device at home for three months to see if it improves mobility, balanc…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking improvements in 150 participants, including hea…

This small study looks at whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis pay better attention and feel less tired. Researchers will use EEG to watch brain activity during hypnosis sessions. The goal is to see if this approach is practi…

This study tests whether adding mild electrical stimulation to balance exercises can improve walking and stability in people with Multiple Sclerosis (MS). Up to 24 participants will be randomly assigned to balance training alone, training with leg muscle stimulation, or training …

This study looks at whether switching from ocrelizumab to ublituximab can help people with multiple sclerosis (MS) who experience a return of symptoms before their next dose. About 50 adults with relapsing MS who have been on ocrelizumab for at least a year and notice this 'weari…

This study tests whether watching and imitating hand movements in virtual reality at home can improve hand dexterity in people with multiple sclerosis. Sixty adults with MS and right-hand weakness will do 15 sessions over 3 weeks. One group watches hand actions; the other watches…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet weekly with a coach online to learn problem-solving and relaxation skills. The goal is to see if the program improves quality of li…

This study tests whether a combined thinking and exercise program done at home can improve memory and walking in people with multiple sclerosis. About 90 adults with MS will be randomly assigned to different training groups. The goal is to see if combining cognitive and motor exe…

This study tests whether a special video game (a "serious game") can improve thinking speed and memory in people with multiple sclerosis. About 150 adults with MS who have memory or thinking complaints will play the game or receive standard care. Researchers will measure changes …

This study tests a wearable device called the Cionic Neural Sleeve in 14 people with multiple sclerosis (MS). The sleeve uses electrical signals to help improve walking speed, reduce disability, and lower fall risk. Participants wear the sleeve for up to 8 hours a day while resea…

This study tests whether a daily 500mg dose of hesperidin, a natural compound found in citrus fruits, can reduce fatigue and improve mood and thinking in people with multiple sclerosis. Over 12 weeks, 60 participants will take either hesperidin or a placebo pill, and researchers …

This study tests whether adding music to rhythmic walking exercises helps people with multiple sclerosis walk better. Thirty-two participants with mild to moderate disability will do four weeks of gait training at home via video calls, either with or without music. The goal is to…

This study looks at whether taking a walking-improvement drug (dalfampridine) along with physical therapy helps people with multiple sclerosis walk better than either treatment alone. About 48 adults with MS who have trouble walking will first try the drug for 6 weeks, then stop …

This study tests a low-intensity strength training program that uses a special cuff to partially block blood flow to the arms or legs. The goal is to see if this approach can safely improve muscle strength, mobility, fatigue, and quality of life in people with advanced multiple s…

This study tests whether a home-based balance training program can improve both physical and cognitive symptoms in people with multiple sclerosis (MS). 75 adults with MS will be randomly assigned to either the balance program or a stretching routine for 4 months. All sessions are…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve walking ability in people with Multiple Sclerosis who have leg stiffness and moderate walking difficulties. About 60 participants will receive either real rTMS or a sham (fake) treatment f…

This study tests whether a full-body stimulation suit used at home can reduce spasticity (muscle stiffness) and ataxia (poor coordination) in people with Multiple Sclerosis. About 70 participants will either use the suit for 6 weeks or continue their usual care. The goal is to se…

This study looks at whether a physical therapy program can help people with multiple sclerosis (MS) increase their physical activity. Exercise can help manage MS symptoms like fatigue, but many people with MS are not active enough. The study will involve 40 adults with MS who are…

This study tests whether a 12-week coaching app that trains goal-directed thinking can make a 6-week memory and speed training more effective for people with Multiple Sclerosis. 126 adults with MS will use the apps and complete questionnaires and brain scans. The goal is to impro…

This study looks at whether listening to Quran recitation can reduce fatigue and boost mental well-being in people with multiple sclerosis. About 52 adults with MS will either listen to Quran recitation or continue their usual care for 4 weeks. Researchers will measure changes in…

This study tests two online programs designed to help people with multiple sclerosis (MS) manage their fatigue. Researchers will enroll 2,000 adults with MS across the U.S. to see if these programs, added to usual care, reduce tiredness better than usual care alone. The study las…

This study tests a device that sends mild electrical pulses to a nerve in the leg to help people with multiple sclerosis (MS) empty their bladder more completely. 68 adults with MS who use a catheter to urinate will use the device for 30 minutes daily for 12 weeks. Half will get …

This study compares two gentle exercise programs—tai chi and square stepping—in women with multiple sclerosis. The goal is to see if these activities improve knee joint awareness, leg strength, and fatigue. About 39 women aged 20 to 45 with relapsing-remitting MS will participate…

This study tests a specially designed, at-home exercise program for African-Americans with multiple sclerosis who live in rural areas. About 100 participants will either do the exercise program or a stretching routine. The goal is to see if the program improves walking, reduces f…

This study is testing a full-body suit that uses mild electrical pulses to help people with conditions like multiple sclerosis and fibromyalgia who experience muscle stiffness, spasms, or pain. About 15 adults will try the suit to see if it improves balance and reduces symptoms. …

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist group receiving usual care. The goal is to see if ex…

This study is testing whether a wearable robotic exoskeleton can help people with multiple sclerosis (MS) improve their walking, memory, and thinking. Ten adults with MS who have moderate to severe walking difficulty and some cognitive problems will use the device during therapy.…

This early-stage study tests a new drug called RO7121932 in 129 people with multiple sclerosis (MS). The main goal is to see if the drug is safe and tolerable when given as a shot or IV. Participants are not on other MS treatments during the study. This is not a cure; it aims to …

This study tests if mentally practicing walking while watching videos of people walking can improve walking in people with Multiple Sclerosis (MS). Twenty participants will either watch walking videos and imagine themselves walking, or watch nature scenes. Researchers will measur…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it can reduce pain and improve movement in people with spasticity (muscle tightness) after a stroke, brain injury, or other conditions. Half of the 50 particip…

This study tests whether low-intensity arm exercises combined with blood flow restriction (using a cuff to partially reduce blood flow) can improve hand strength, coordination, and quality of life in people with multiple sclerosis. About 20 adults with MS will be randomly assigne…

This study tests a wearable suit called EXOPULSE that uses 50 electrodes to stimulate muscles and reduce stiffness in people with multiple sclerosis. About 77 participants with moderate disability will use the suit at home for one hour every other day. The goal is to see if it im…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study tests two ways to deliver cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers want to see which approach improves sleep, reduces fatigue, and may protect the brain…

This study tests whether adding musical sound cues to standard walking therapy helps people with Parkinson's disease, stroke, or multiple sclerosis walk better and feel less tired. About 120 adults will either get standard rehab or rehab with these sound cues. The goal is to see …

This study tests whether adding simple mental tasks (like counting backwards) to exercise can improve walking, balance, and thinking in people with multiple sclerosis. Forty adults with MS will do supervised exercise sessions twice a week for 8 weeks. The goal is to find better r…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers want to see if this high-t…

This study looks at whether certain brain lesions in multiple sclerosis (MS) that have a rim of iron around them are linked to more severe disability. Researchers will analyze old MRI scans and collect new blood samples from 100 people with MS to see if genetic differences affect…

This study looks at how sleep issues impact fatigue and memory in people with multiple sclerosis (MS). Researchers will use overnight sleep tests and thinking assessments in about 382 MS patients and a control group without MS. The goal is to understand the link between sleep, ti…

This study watches 842 people with multiple sclerosis who are starting a new under-the-skin injection of ocrelizumab. Researchers will ask how satisfied patients are with the injection after 12 months and check nerve health markers. The goal is to understand real-world experience…

This study looks at how multiple sclerosis (MS) damages the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers at Mayo Clinic will test 13 people (some with MS, some healthy) using simple lab exercises to measure …

This study is building a large database of health information from 2,000 people with multiple sclerosis (MS). Researchers will use electronic health records and patient surveys to track disability and thinking problems over time. The goal is to find better ways to improve MS care…

This study is creating a large database and biobank from 2200 patients with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to identify new ma…

This study aims to understand how multiple sclerosis (MS) damages the brain and spinal cord over a person's lifetime. Researchers will follow 250 adults with MS or similar conditions, using yearly MRI scans, eye tests, and other exams. Participants agree to donate their brain and…

This study looks at how multiple sclerosis (MS) affects the autonomic nervous system, which controls things like blood pressure, sweating, and body temperature. Researchers will study 60 people with two types of MS (relapsing-remitting and primary progressive) during a rehabilita…

This study observes pregnant women with multiple sclerosis to see if taking BRIUMVI affects the baby's health. It compares birth defect rates between women who used BRIUMVI during pregnancy and those who did not. About 728 participants will provide data to help doctors understand…

This study looks at whether multiple sclerosis (MS) affects a woman's ovarian reserve—the number of eggs left in her ovaries. Researchers will compare women with MS to healthy women aged 25 to 35 using blood tests and ultrasound. The goal is to better understand MS's impact on fe…

This study follows 400 adults with relapsing-remitting multiple sclerosis for 3 years. Researchers use MRI scans to measure brain shrinkage and compare people on high-efficacy treatments versus medium-efficacy treatments. The goal is to find out which treatment better slows disea…

This study is trying to figure out what makes someone more likely to develop multiple sclerosis (MS). Researchers are looking at a person's genes, their environment, and their immune system. They hope to create a risk score that could one day help prevent or slow down MS. The stu…

This study looks at how bacteria in your gut might be linked to brain aging and diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will compare 200 people—healthy young and older adults, plus those with early Alzheimer's, Parkinson's, or MS—using brain sc…

This study looks at whether measuring certain proteins (free light chains) in spinal fluid can help predict the future course of multiple sclerosis (MS). Researchers will follow 100 adults with MS or optic neuritis to see if these protein levels relate to disability, relapses, an…

This study will test the hearing of 30 people with multiple sclerosis using simple ear exams and brain-wave tests. Researchers will also collect a small sample of spinal fluid to look for signs of inflammation. The goal is to see if hearing problems in MS are linked to inflammati…

This study follows pregnant women with multiple sclerosis who have taken ZEPOSIA to see how it affects their pregnancy and their baby's health. Researchers will collect information on birth defects, pregnancy complications, and infant development. The goal is to help patients and…

This study looks at how muscle stiffness (spasticity) affects people with multiple sclerosis. Researchers will classify spasticity patterns in the arms and legs of 75 adults with MS and see how these patterns relate to quality of life. The goal is to help doctors create better, p…

This study looks at how people with early-stage multiple sclerosis (MS) adjust their walking to sudden changes, like obstacles or uneven surfaces. Researchers will compare 32 adults with MS to healthy adults using special treadmills and brain activity monitors. The goal is to fin…

This study uses a special PET-MRI scan with a tracer called [18F]-DPA-714 to see inflammation in the brains of 41 people with active multiple sclerosis (MS). The goal is to better understand how inflammation relates to MS symptoms and to create a standard method for using this sc…

This study looks at how body awareness and trunk (core) stability are linked to arm and hand function in people with multiple sclerosis (MS). Researchers will measure these factors in 50 people with MS and compare them to healthy volunteers. The goal is to better understand these…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study aims to find early warning signs and risk factors for multiple sclerosis (MS) in people who do not yet have any symptoms. Researchers will collect medical data and samples from 1,000 adults with certain MS risk factors, such as family history or past Epstein-Barr virus…

This study looks at whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are easy for adults with chronic conditions like IBD, hypertension, multiple sclerosis, or anemia to take regularly. Researchers will also check if these supplements help the body ab…

This study aims to understand why multiple sclerosis (MS) is mild in some people but severe and disabling in others. Researchers will compare blood cells from 130 people with aggressive MS, non-aggressive MS, and healthy volunteers. They will use advanced genetic and cell analysi…

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study is following 7,500 people with multiple sclerosis (MS) and healthy volunteers for up to 30 years. The goal is to learn why MS affects each person differently and why some treatments work better for some. By tracking participants over time, researchers hope to find ways…

This study looks at why people with multiple sclerosis (MS) feel so tired. Researchers will use a gentle, non-invasive brain stimulation technique called tDCS to see if it can change brain activity and reduce fatigue. 84 adults with relapsing-remitting MS will take part, and the …

This study looks at how mood and insomnia affect the burden on caregivers of people with multiple sclerosis (MS). Researchers will ask 50 caregivers and their loved ones with MS to fill out questionnaires about sleep, anxiety, depression, and caregiving challenges. The goal is to…

This study uses a new type of PET scan to look at brain connections (synapses) in people with progressive multiple sclerosis (MS). Researchers will compare these scans with standard MRI and blood tests to better understand how MS damages the brain. The goal is to learn more about…

This study looks at how pelvic floor problems in people with multiple sclerosis (MS) are connected to core endurance, hip rotation strength, and activation of certain leg muscles. Researchers will assess 73 participants using questionnaires and physical tests. The goal is to bett…

This study looks at how the brain uses sugar (glucose) in people with multiple sclerosis (MS) compared to healthy volunteers. Researchers will use a special PET scan to measure brain activity and compare it with standard MRI scans and blood tests. The goal is to find better ways …

This study looks at how walking patterns and MRI brain scans can help explain walking difficulties in people with multiple sclerosis (MS). About 100 adults with MS will wear a small device while walking and have an MRI scan. The goal is to better understand walking problems, not …

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with brain conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based tests with standard in-p…

This study looks at blood and spinal fluid from 150 people with multiple sclerosis (MS) or early symptoms to find which immune cells cause damage. Researchers hope to identify new targets for treatments, especially for progressive MS. Participants must be 18 or older and already …

This study watches for side effects in 30 Taiwanese adults with relapsing-remitting multiple sclerosis who are starting fingolimod. It does not test a new treatment but collects safety data over one year. Participants must not have used fingolimod before and must meet other healt…

This study looks at muscle and heart health in people over 60 with multiple sclerosis (MS) compared to those without MS. Participants will do a 4-month exercise program to see how their bodies adapt. The goal is to understand how MS and aging together affect muscle function and f…

This study explores whether sleep apnea makes multiple sclerosis (MS) worse. Researchers will collect sleep tests, MRI scans, and lab results from 800 adults with MS to see if there is a link. The goal is to understand how sleep apnea might affect MS symptoms and brain changes. N…

This study looks at how the antibiotic vancomycin changes gut bacteria and immune cells in people newly diagnosed with multiple sclerosis (MS). Researchers want to understand the link between gut health and brain inflammation. Twelve participants will take vancomycin for up to 6 …

This study uses MRI scans to watch how multiple sclerosis (MS) changes in the brain over time. Researchers will follow up to 3750 people, including those with MS, those starting new treatments, and healthy volunteers. The goal is to better understand how the disease progresses an…

This study looks at how well people with multiple sclerosis (MS) can sense changes in their own walking and standing-up movements compared to healthy volunteers. About 88 participants (44 with MS and 44 without) will perform simple tasks over up to three days. The goal is to iden…

This study uses a special PET scan to look at a brain chemical system (norepinephrine) in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and trouble thinking. About 19 people will take …

This study collects health data from 7000 people with multiple sclerosis (MS) and related conditions. The goal is to use this information to train artificial intelligence (AI) tools that can help doctors diagnose MS earlier and predict how the disease will progress. Participants …

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…

This study explores whether short selfie videos taken on a smartphone can reliably measure walking and speech changes in people with multiple sclerosis (MS). Researchers will compare video data with standard in-person tests to see if remote monitoring is accurate and practical. A…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. Researchers will enroll 52 adults who use a walking aid most of the time due to a leg injury, stroke, or multiple sclerosis. Participants …

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers will look for T cells that are active in inflamed tissues to find their targets. The goal is to discover new targets for future …

This study is collecting health data from 100 people with multiple sclerosis (MS) to find new ways to track the disease. Researchers will use artificial intelligence to analyze medical images, genetic information, and smartphone data. The goal is to better understand how MS chang…

This study compares brain aging in 200 people—half with multiple sclerosis (MS) and half healthy—using advanced MRI scans. The goal is to see if MS speeds up brain aging and to find better ways to measure it. Participants will have MRI scans and assessments, but no treatment is g…

This study looks at 60 people with multiple sclerosis to find specific scores on walking and balance tests that can tell who is at risk of falling. Participants will walk on a special mat and stand on a balance platform. The goal is to catch fall risk early so steps can be taken …

This study looks at two new tests—the Walking Adaptability Ladder Test and the Foot Tap Test—to see if they can detect subtle walking and motor problems in people with mild multiple sclerosis (MS). About 100 participants with mild MS and healthy volunteers will take part. The goa…

This study collects information from people with multiple sclerosis over many years to better understand the disease and how it changes. Participants fill out short surveys twice a year online or by mail. The goal is to help researchers spot patterns and improve future care.

This study looks for easy ways to detect early signs of multiple sclerosis and Parkinson's disease in drivers. Researchers will test 200 drivers with these conditions using computer-based tasks that measure attention, reaction time, and impulse control. The goal is to find simple…

This study aims to develop a non-invasive eye-tracking app to monitor multiple sclerosis (MS) progression and cognitive changes. About 168 adults with MS and healthy volunteers will take cognitive tests and eye movement measurements over 48 months. The data will train machine lea…

This study looks at how often sexual problems occur in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. About 140 women with relapsing-remitting MS will fill out questionnaires and take simple tests. T…

This study looks at whether using virtual reality (VR) with wearable sensors can help people with multiple sclerosis (MS) improve their walking while using a leg brace. The goal is to see if this approach is practical and enjoyable for patients, and if it gives doctors better inf…

This study tests whether a special radioactive tracer can help PET scans find certain immune cells (CD8+ T cells) in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults will receive the tracer and u…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study uses a special PET scan to look at brain inflammation in people with multiple sclerosis or Alzheimer's disease, compared to healthy volunteers. Researchers want to see if the pattern of inflammation differs between these diseases and relates to symptoms. Up to 250 adul…

This study follows about 1,178 pregnant women with multiple sclerosis to see if taking the drug diroximel fumarate (VUMERITY®) affects their babies. Researchers will compare birth outcomes among women who took the drug, those who took other MS drugs, and those who took no MS drug…

This study tests whether special breathing exercises can improve brain and mental health in people with multiple sclerosis or cancer, and their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connecti…

This early-stage study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will part…

This study tests whether breathing small amounts of low oxygen (like at a high altitude) for less than a minute at a time can improve ankle strength in people with multiple sclerosis. Researchers will measure brain activity and muscle strength before and after the breathing sessi…

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study looks at whether signs of inflammation in spinal fluid can predict which multiple sclerosis (MS) drugs a person will respond to. About 250 adults with progressive MS will take one or two study drugs for up to 18 months. Researchers will track changes in disability and …

This study looks at whether aerobic exercise (stationary biking) and daytime naps can improve how people with relapsing-remitting multiple sclerosis learn and remember motor skills. Twenty adults aged 18-70 will participate. The goal is to understand how these simple activities a…

This study looks at why some women with multiple sclerosis have trouble controlling their bladder. Researchers will measure pelvic floor muscle activity and check how incontinence affects quality of life, physical activity, and fatigue. About 47 women aged 30-50 with MS and urina…

This study looks at how difficult childhood experiences might impact the course of multiple sclerosis (MS), especially in Black, Hispanic, and low-income communities. Researchers will use surveys, MRI scans, and blood tests to measure MS severity and quality of life. The goal is …

This study looks at people with relapsing-remitting multiple sclerosis to understand why abnormal inflammation in the brain continues even after treatment. Researchers will use brain scans and analyze spinal fluid to compare different types of inflammation. The goal is to learn m…

This study tests a new radioactive tracer called [18F]FZTA to see if it can spot inflammation in the brain using PET scans. Researchers will compare healthy adults and people with Multiple Sclerosis (MS) to see if the tracer lights up areas of inflammation. The goal is to better …

This study aims to learn more about inflammatory diseases of the brain and spinal cord, such as multiple sclerosis (MS), which may be caused by the immune system attacking the body. Researchers will compare tests from 2,400 people—both healthy volunteers and those with symptoms o…

This study is looking for better ways to predict when multiple sclerosis (MS) will get worse, especially the switch from relapsing-remitting MS to a more progressive form. Researchers will use powerful MRI scans to measure brain chemicals and tissue changes in 50 adults with MS. …

This study tests whether a breathing technique called acute intermittent hypoxia (AIH) can help improve arm and hand function in people with multiple sclerosis (MS). AIH involves breathing short bursts of low oxygen, which has previously been shown to safely increase ankle streng…

This study aims to understand how people with multiple sclerosis (MS), their carers, and healthcare professionals experience the complex care system. Researchers will interview 57 participants in France and Italy to identify what makes a care pathway feel supportive or frustratin…

This study looks at whether low levels of immunoglobulins (antibodies) are a treatable cause of fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates between MS patients with and without low antibody levels. The goal is to und…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. The goal is to see if those with pain and fatigue have higher levels of brain inflammation. Researchers will compare…

This study looks at why some people with multiple sclerosis (MS) have trouble controlling their bladder. Researchers will measure pelvic floor muscle activity and ask about symptoms and daily life. About 47 adults with MS and urinary incontinence will take part. The goal is to be…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE suit affects their balance and walking over time. Participants will be followed during routine care, and research…

This study looks at whether adding a brain specialist (neuropsychologist) to a rehabilitation team can help people with multiple sclerosis (MS) stay at work and feel better. Twenty adults with MS will get cognitive testing and support, then be followed for two years. The goal is …

This study is watching how doctors use a blood test that measures nerve damage (called sNfL) to make decisions for people with relapsing multiple sclerosis. About 700 adults in Germany will take part, and researchers will track how often the test is used and what changes in treat…

This study looks at how multiple sclerosis (MS) changes the way people walk. Researchers will use motion cameras, pressure mats, and wearable sensors to measure walking in 30 adults with MS and healthy volunteers. The goal is to better understand gait problems, not to test a trea…

This study looks at whether a substance in urine, called S1P, can help doctors check for bladder overactivity in people with multiple sclerosis (MS). Bladder problems are common in MS, but the current best test is uncomfortable and invasive. Researchers will measure S1P levels in…