Can online therapy help MS patients sleep better and protect their brains?

NCT ID NCT06434571

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two ways of delivering cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers will compare these to usual care to see which improves sleep, reduces fatigue, and enhances quality of life. They will also explore whether better sleep may help protect the brain. The trial enrolls 90 adults aged 18–65 with relapsing-remitting or secondary progressive MS and mild-to-moderate disability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cognitive behavioral therapy for insomnia (CBT-I) delivered via telehealth or web-based platform
What this could lead to
If successful, this could provide an effective, accessible treatment for insomnia and fatigue in people with multiple sclerosis, potentially also supporting brain health.
What could go wrong
This is a Phase 2 trial with only 90 participants, so results may not apply to everyone. The exploratory brain protection goal is very early and uncertain.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Kansas Medical Center- Sleep, Health and Wellness Laboratory

    RECRUITING

    Kansas City, Kansas, 66160, United States

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Other studies related to the condition(s) this trial covers.