INSOMNIA

This study tests a combined approach to help people stop using sleep medications safely. Researchers will compare supervised medication tapering alone versus tapering plus a digital cognitive behavioral therapy program for insomnia. The goal is to reduce reliance on sleep aids an…

This study tests whether a sleep drug (lemborexant) can lower levels of brain-damage-related proteins in the blood of adults with insomnia. Twenty participants aged 40–65 will take the drug or a placebo for two weeks each. The goal is to see if improving sleep can reduce markers …

This study checks if wearable devices like movement sensors, EEG headbands, and smartphones can accurately measure sleep stages compared to the standard sleep lab test (polysomnography). It involves 96 healthy volunteers and people with sleep issues like insomnia or sleep apnea. …

This study tests a program called TAILOR that helps teenagers with insomnia improve their sleep. The goal is to see if better sleep can lower their risk of suicidal thoughts and actions. The study will include 235 teens aged 11 to 18 who have had recent suicidal thoughts and slee…

This study tests a mindfulness-based sleep program for pregnant women with insomnia to see if it can prevent depression during and after pregnancy. 500 participants will be assigned to either the sleep program or standard care. The goal is to improve sleep and reduce the risk of …

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent future depression and anxiety. About 3,000 students in Swedish high schools will take part, and their results will be compared to stude…

This study looks at older adults (50+) with PTSD and ongoing insomnia. After a talk therapy for PTSD, those with remaining sleep issues will get a non-drug sleep program. Researchers will check if this improves sleep, PTSD symptoms, heart health markers like blood pressure, and q…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, on stable …

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. About 120 adults with insomnia and depression will receive the sleep intervention and undergo brain scans to measure changes. The goal is to…

This study tests a nurse-guided brief behavioral treatment for insomnia in people recovering from traumatic brain injury. About 93 participants will receive either in-person or mobile-delivered therapy to improve sleep, mood, and thinking. The goal is to find a simple, effective …

This study tests whether a type of talk therapy for insomnia (CBT-I) can also reduce impulsive behavior and risk-taking in young people aged 12 to 24. Researchers will measure changes in impulsivity and sleep quality over time. The goal is to see if improving sleep can help preve…

This study is testing whether a web-based program called SHUTi can help Black/African American prostate cancer survivors sleep better. About 40 people will be randomly assigned to either the SHUTi program or an educational website. The goal is to see if the online treatment is pr…

This study tests a new way to improve sleep in people with mild cognitive impairment (MCI). It combines gentle brain stimulation (transcranial magnetic stimulation) with talk therapy (cognitive behavioral therapy for insomnia). The goal is to see if this approach can help with sl…

This study tests whether the sleep medication suvorexant can help people with opioid use disorder who also have insomnia fall asleep and stay asleep longer. About 300 adults on stable medication for opioid use disorder will receive either suvorexant or a placebo for 8 weeks. Rese…

This study tests if stimulating specific points on the ear can improve stomach discomfort and sleep in people with functional dyspepsia (chronic indigestion) and insomnia. Researchers will enroll 176 adults and compare the ear stimulation to a placebo. The goal is to see if this …

This study is testing a sleep medication called lemborexant in 121 adults who have both a mental health condition and insomnia. Participants take the drug for 8 weeks, and researchers track how well it improves sleep and any side effects. The goal is to see if this treatment work…

This study compares two treatments for insomnia in perimenopausal women: hormone replacement therapy (HRT) and cognitive behavioral therapy (CBT-I). 54 women with hot flashes and poor sleep will receive either HRT, weekly CBT sessions, or basic sleep tips for 8 weeks. The goal is…

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to exercise, cognitive behavioral therapy for insomnia, or both, with online coaching for 12 month…

This study tests whether personalized behavioral programs can improve sleep in first-time mothers struggling with insomnia. 135 women will either receive a sleep management program, an aerobic exercise program, or standard postpartum care. Participants track sleep, activity, and …

This study tests whether lemborexant, a sleep medication, can help improve both motor symptoms and sleep issues in people with Parkinson's disease. About 44 adults aged 50 and older with Parkinson's and insomnia will take the drug and be monitored for changes in movement and slee…

This study compares two types of talk therapy for insomnia in 160 active-duty military members who have had a mild traumatic brain injury and still have sleep and other symptoms for at least 3 months. One therapy is 6 sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I),…

This study tests whether treating both frequent nighttime urination (nocturia) and insomnia together works better than treating each alone. Researchers will enroll 192 adults aged 60 and older who wake up to urinate at least twice per night and have trouble sleeping. The goal is …

This study tests a digital cognitive behavioral therapy (CBT) program for people with insomnia. Researchers will enroll 200 adults to see if the app-based treatment improves sleep, anxiety, depression, and quality of life, while also measuring costs. The goal is to find a conveni…

This study looks at whether adding sleep restriction therapy to cognitive-behavioral therapy (CBT) helps children aged 7-11 with insomnia sleep better. 120 children will be split into three groups: CBT with sleep restriction, CBT without it, or a waitlist. Researchers will track …

This study tests whether a fast, 5-day group therapy program can improve PTSD, insomnia, and nightmares in veterans and active-duty military. 160 participants will receive either a specialized cognitive-behavioral therapy or sleep education, both combined with a proven PTSD writi…

This study tests an internet-based sleep program for public safety personnel (like police, firefighters, and paramedics) who have trouble sleeping. About 60 participants will learn skills to manage their sleep difficulties on their own. The goal is to see if the program helps imp…

This study looks at whether treating insomnia can improve sleep and possibly reduce pain and inflammation in people with Crohn's disease. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep intervention. The main goal is to see if the treatment …

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women who are overweight and have insomnia will get either sleep therapy or sleep education, followed by a weight loss program. The goal is to see if better sleep leads to greater weig…

This study tests whether a type of talk therapy for insomnia (CBTi) can help people with type 1 diabetes sleep better and control their blood sugar. About 15 adults with type 1 diabetes and poor sleep will either get 8 virtual therapy sessions or health education emails. Research…

This study tests whether a non-invasive brain stimulation technique called TMS can improve sleep in people with insomnia. Over 2 weeks, 144 adults will receive either real TMS to different brain areas or a sham (fake) treatment. Researchers will monitor sleep at home and in the l…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep more easily. Thirty adults with long-term sleep problems will be split into three groups: one using the app with guided meditation, one using the app without g…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists learn to use proven methods like cognitive behavioral therapy and mindfulness to help with anxiety, depression, pain, fatigue, …

This study tests a web-based program called NiteCAPP to improve sleep in 100 rural dementia caregivers who have insomnia. Participants will use the program and report on their sleep, mood, and stress over 12 months. The goal is to see if the program helps caregivers sleep better …

This study looks at ways to help people complete an online program for insomnia called digital cognitive behavioral therapy (dCBT-I). Researchers will track 600 adults with insomnia to see what factors—like sleep environment or daily habits—affect whether people finish the progra…

This study tests a version of Cognitive Behavioral Therapy for Insomnia (CBT-I) that was adapted specifically for teenagers. About 28 teens aged 13-18 with chronic insomnia will either receive 4-6 virtual therapy sessions or be placed on a waitlist. Researchers will measure sleep…

This study tests whether a smartphone app called iCANSleep can help cancer survivors with insomnia sleep better. The app uses a proven therapy called Cognitive Behavioural Therapy for Insomnia (CBT-I). Researchers will compare the app to a waitlist in 146 Canadian cancer survivor…

This pilot study from Stanford University aims to find out if giving rTMS (a non-invasive brain stimulation) in the morning or evening works better for treating insomnia. Ten adults with insomnia will receive ten sessions over two weeks. Researchers will track sleep quality and b…

This study tests a parent-led sleep program delivered online for children aged 6-12 with autism and insomnia. The program teaches parents behavioral strategies to improve their child's sleep, with some families getting extra personalized support. Researchers will also check if be…

This study compares three common insomnia treatments—trazodone, daridorexant, and online cognitive behavioral therapy—in 1,000 women aged 40-62 who are in perimenopause or early menopause. Participants take nightly medication or complete a behavioral program for 12 months, tracki…

This study tests an online program designed to improve sleep and thinking in adults aged 60 and older who have trouble sleeping and notice memory or concentration issues. The program teaches healthy sleep habits and coping strategies. Researchers will compare it to a control grou…

This study tests a virtual cognitive behavioral therapy program designed to help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home and report how easy and helpful it is. The goal is to see if this approach …

This study tests a guided online program for insomnia in 80 adults who had a moderate to severe traumatic brain injury at least one year ago. The program is a computerized version of cognitive behavioral therapy for insomnia (cCBT-I) and is compared to usual care. The goal is to …

This study tests a culturally adapted internet-based therapy (i-CBT) for Farsi/Dari-speaking migrants and refugees aged 15-29 who have symptoms of anxiety, depression, or stress. Participants will receive the therapy or be in a control group. The goal is to see if this approach r…

This study tests whether a mobile health program (mPATH) can help low-income older adults who have trouble sleeping and are not very active. Participants will use a smartphone app to increase physical activity, and researchers will measure changes in memory and sleep quality. The…

This study tests whether using a special blanket for 4 weeks can improve sleep in 672 young people aged 16-24 who have trouble sleeping. Participants are split into three groups: two get different blankets, and one gets no blanket for comparison. The goal is to find a safe, drug-…

This study looks at whether adding a meditation program or extra pain education to standard sleep therapy can help reduce pain intensity in adults with chronic low back pain and insomnia. About 300 participants will receive cognitive behavioral therapy for insomnia, then be assig…

This study tests a short program to help young adults (ages 18-29) who have trouble sleeping and also drink heavily or use marijuana. The goal is to see if the program can reduce drinking and cannabis use while improving sleep. About 800 people in Washington State will take part.

This study tests a small, non-invasive earbud that gently stimulates a nerve in the ear to see if it can improve sleep in adults who survived childhood leukemia and now have insomnia. About 40 participants will use either the active device or a sham (inactive) version nightly for…

This study aims to find the best way to treat insomnia and depression together using digital behavioral programs. Researchers will compare different treatment sequences to see which order works best. The study involves 1,500 U.S. military veterans who have both conditions. The go…

This study tests whether a smartphone app called SleepUp can help people with insomnia sleep better. The app provides therapy based on proven techniques, including sleep tips, relaxation exercises, and virtual coaching. About 280 adults with mild or worse insomnia will use the ap…

This study tests a special version of cognitive behavioral therapy for insomnia (CBT-I) designed for women veterans who have both insomnia and PTSD. About 100 women will either get this therapy or a sleep education program. The goal is to see if improving sleep makes them more re…

This study tests whether a special sleep education program can improve sleep quality and reduce depression in menopausal women. 500 women will be randomly assigned to either receive the education or be in a control group. The program teaches about sleep, motivation, and skills to…

This study compares two types of talk therapy for insomnia given over video or phone. It involves 350 adults who have trouble sleeping and face economic or social disadvantages. The goal is to see if a shorter, simpler therapy works as well as the standard longer one, making slee…

This study tests an online sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers want to see if it works and if people find it helpful. About 56 adults in Saskatchewan will take part…

This study tests a wellness program for adults with cystic fibrosis who feel very tired. The program includes coaching sessions to help improve fatigue, sleep, and physical activity. Researchers will see if people stick with the program and if it helps them feel better compared t…

This study compares two behavioral sleep training methods for infants with insomnia: 'bedtime checking' (only at bedtime) and 'standard checking' (also during night-wakings). Researchers will track sleep patterns in 270 infants and their parents using wristwatch-like devices and …

This study tests whether a mindfulness-based sleep program can help Black women with insomnia sleep better and feel less stressed. Researchers will enroll 340 Black women who have trouble sleeping and track changes in sleep quality, stress levels, and overall health. The goal is …

This study looks at two treatments for chronic insomnia: cognitive behavioral therapy (CBT-I) and a low-dose medication called trazodone. Researchers want to see which works better for different types of insomnia and whether improving sleep also helps lower blood pressure. About …

This study tests whether adding a sleep improvement program to personalized exercise coaching helps older adults with knee osteoarthritis feel less pain. About 288 participants with knee pain and insomnia will receive either exercise coaching alone or exercise plus sleep treatmen…

This study tests two ways to deliver cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers want to see which approach improves sleep, reduces fatigue, and may protect the brain…

This study tests a digital sleep improvement program (a mobile app and a wrist tracker) in 50 older adults (65+) who are having hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surgery. Participants must have mild i…

This study looks at whether people with insomnia need more or less anesthesia during a digestive endoscopy compared to people who sleep normally. Researchers will track the total amount of anesthetic used and watch for side effects. About 3,360 adults aged 18–64 will take part. T…

This study follows about 785 pregnant women with insomnia to compare outcomes for those who took the sleep medication QUVIVIQ during pregnancy versus those who did not. Researchers will look for birth defects and pregnancy complications. The goal is to gather safety information, …

This study is looking at whether brain scans can help predict how well people with depression, insomnia, or social anxiety will respond to internet-based cognitive behavioral therapy (iCBT). Researchers will measure brain activity patterns in 150 patients and 75 healthy volunteer…

This study looks at whether people with insomnia need a different amount of the sedative ciprofol during a digestive endoscopy compared to people who sleep normally. About 840 adults aged 18-64 will take part. The goal is to help doctors give the right dose for safer and more com…

This study looks at how getting only 4 hours of sleep for three nights, or having insomnia, changes the way people handle their emotions. Researchers will compare these groups to people who sleep normally. They use brain scans and emotion tasks to understand the effects. The goal…

This study looks at how poor sleep during pregnancy can increase stress and the risk of mental health issues like depression and anxiety after giving birth. Researchers will follow 114 pregnant women and test an online, automated therapy designed to improve sleep. The goal is to …

This study looks at whether people with insomnia need a different amount of the sedative rimazolen during a digestive endoscopy compared to people who sleep normally. Researchers will track the total sedative used and watch for side effects like breathing or heart problems. The g…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep problems. Researchers will track insomnia symptoms over the first year using questionnaires. The goal is to understand when and why sleep issues start and what factors—like treatment type or emotion…

This study follows 82 children aged 8-18 who have both obstructive sleep apnea and insomnia and are starting positive airway pressure (PAP) therapy. Researchers want to see if insomnia makes it harder for kids to use their PAP machine regularly, and whether race or ethnicity play…

This study looks at how insomnia affects a brain chemical called norepinephrine, which helps control sleep and thinking. Researchers will measure this chemical in 60 older adults (55+) with and without insomnia, and test if bright light exposure can improve sleep and memory. The …

This study looks at whether people with insomnia need more or less of the sedative etomidate during a digestive endoscopy (a scope procedure). Researchers will compare 840 adults—some with insomnia and some with normal sleep—to see if sleep problems affect sedation requirements. …

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…